The tankyrase inhibitor G007-LK inhibits small intestine LGR5+ stem cell proliferation without altering tissue morphology

The tankyrase inhibitor G007-LK inhibits small intestine LGR5+ stem cell proliferation without altering tissue morphology

Abstract Background The WNT pathway regulates intestinal stem cells and is frequently disrupted in intestinal adenomas. The pathway contains several potential biotargets for interference, including the poly-ADP ribosyltransferase enzymes tankyrase1 and 2. LGR5 is a known WNT pathway target gene and...

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Autores principales: Norum,Jens Henrik, Skarpen,Ellen, Brech,Andreas, Kuiper,Raoul, Waaler,Jo, Krauss,Stefan, Sørlie,Therese
Lenguaje:English
Publicado: Sociedad de Biología de Chile 2018
Materias:
Tankyrase inhibitor
LGR5
WNT signalling
Intestine
Lineage tracing
Stem cell
Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602018000100203
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