The tankyrase inhibitor G007-LK inhibits small intestine LGR5+ stem cell proliferation without altering tissue morphology

The tankyrase inhibitor G007-LK inhibits small intestine LGR5+ stem cell proliferation without altering tissue morphology

Abstract Background The WNT pathway regulates intestinal stem cells and is frequently disrupted in intestinal adenomas. The pathway contains several potential biotargets for interference, including the poly-ADP ribosyltransferase enzymes tankyrase1 and 2. LGR5 is a known WNT pathway target gene and...

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Main Authors: Norum,Jens Henrik, Skarpen,Ellen, Brech,Andreas, Kuiper,Raoul, Waaler,Jo, Krauss,Stefan, Sørlie,Therese
Language:English
Published: Sociedad de Biología de Chile 2018
Subjects:
Tankyrase inhibitor
LGR5
WNT signalling
Intestine
Lineage tracing
Stem cell
Online Access:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602018000100203
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