Electroacupuncture ameliorate learning and memory by improving N -acetylaspartate and glutamate metabolism in APP/PS1 mice

Abstract Objective To explore the precise mechanism of electroacupuncture (EA) to delay cognitive impairment in Alzheimer disease. Methods N -Acetylaspartate (NAA), glutamate (Glu) and myoinositol (mI) metabolism were measured by magnetic resonance spectroscopy, learning and memory of APP/PS1 mous...

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Autores principales:	Lin,Ruhui, Li,Long, Zhang,Yingzheng, Huang,Sheng, Chen,Shangjie, Shi,Jiao, Zhuo,Peiyuan, Jin,Hao, Li,Zuanfang, Liu,Weilin, Wang,Zhifu, Chen,Lidian, Tao,Jing
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2018
Materias:	Magnetic resonance spectroscopy (MRS Electroacupuncture Learning and memory N-Acetylaspartate (NAA Glutamate (Glu)
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602018000100218
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spelling	oai:scielo:S0716-976020180001002182018-08-20Electroacupuncture ameliorate learning and memory by improving N -acetylaspartate and glutamate metabolism in APP/PS1 miceLin,RuhuiLi,LongZhang,YingzhengHuang,ShengChen,ShangjieShi,JiaoZhuo,PeiyuanJin,HaoLi,ZuanfangLiu,WeilinWang,ZhifuChen,LidianTao,Jing Magnetic resonance spectroscopy (MRS Electroacupuncture Learning and memory N-Acetylaspartate (NAA Glutamate (Glu) Abstract Objective To explore the precise mechanism of electroacupuncture (EA) to delay cognitive impairment in Alzheimer disease. Methods N -Acetylaspartate (NAA), glutamate (Glu) and myoinositol (mI) metabolism were measured by magnetic resonance spectroscopy, learning and memory of APP/PS1 mouse was evaluated by the Morris water maze test and the step-down avoidance test, neuron survival number and neuronal structure in the hippocampus were observed by Nissl staining, and BDNF and phosphorylated TrkB detected by Western blot. Results EA at DU20 acupuncture significantly improve learning and memory in behavioral tests, up-regulate NAA, Glu and mI metabolism, increase the surviving neurons in hippocampus, and promote the expression of BDNF and TrkB in the APP/PS1 transgenic mice. Conclusion These findings suggested that EA is a potential therapeutic for ameliorate cognitive dysfunction, and it might be due to EA could improve NAA and Glu metabolism by upregulation of BDNF in APP/PS1 mice.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.51 20182018-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602018000100218en10.1186/s40659-018-0166-7
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Magnetic resonance spectroscopy (MRS Electroacupuncture Learning and memory N-Acetylaspartate (NAA Glutamate (Glu)
spellingShingle	Magnetic resonance spectroscopy (MRS Electroacupuncture Learning and memory N-Acetylaspartate (NAA Glutamate (Glu) Lin,Ruhui Li,Long Zhang,Yingzheng Huang,Sheng Chen,Shangjie Shi,Jiao Zhuo,Peiyuan Jin,Hao Li,Zuanfang Liu,Weilin Wang,Zhifu Chen,Lidian Tao,Jing Electroacupuncture ameliorate learning and memory by improving N -acetylaspartate and glutamate metabolism in APP/PS1 mice
description	Abstract Objective To explore the precise mechanism of electroacupuncture (EA) to delay cognitive impairment in Alzheimer disease. Methods N -Acetylaspartate (NAA), glutamate (Glu) and myoinositol (mI) metabolism were measured by magnetic resonance spectroscopy, learning and memory of APP/PS1 mouse was evaluated by the Morris water maze test and the step-down avoidance test, neuron survival number and neuronal structure in the hippocampus were observed by Nissl staining, and BDNF and phosphorylated TrkB detected by Western blot. Results EA at DU20 acupuncture significantly improve learning and memory in behavioral tests, up-regulate NAA, Glu and mI metabolism, increase the surviving neurons in hippocampus, and promote the expression of BDNF and TrkB in the APP/PS1 transgenic mice. Conclusion These findings suggested that EA is a potential therapeutic for ameliorate cognitive dysfunction, and it might be due to EA could improve NAA and Glu metabolism by upregulation of BDNF in APP/PS1 mice.
author	Lin,Ruhui Li,Long Zhang,Yingzheng Huang,Sheng Chen,Shangjie Shi,Jiao Zhuo,Peiyuan Jin,Hao Li,Zuanfang Liu,Weilin Wang,Zhifu Chen,Lidian Tao,Jing
author_facet	Lin,Ruhui Li,Long Zhang,Yingzheng Huang,Sheng Chen,Shangjie Shi,Jiao Zhuo,Peiyuan Jin,Hao Li,Zuanfang Liu,Weilin Wang,Zhifu Chen,Lidian Tao,Jing
author_sort	Lin,Ruhui
title	Electroacupuncture ameliorate learning and memory by improving N -acetylaspartate and glutamate metabolism in APP/PS1 mice
title_short	Electroacupuncture ameliorate learning and memory by improving N -acetylaspartate and glutamate metabolism in APP/PS1 mice
title_full	Electroacupuncture ameliorate learning and memory by improving N -acetylaspartate and glutamate metabolism in APP/PS1 mice
title_fullStr	Electroacupuncture ameliorate learning and memory by improving N -acetylaspartate and glutamate metabolism in APP/PS1 mice
title_full_unstemmed	Electroacupuncture ameliorate learning and memory by improving N -acetylaspartate and glutamate metabolism in APP/PS1 mice
title_sort	electroacupuncture ameliorate learning and memory by improving n -acetylaspartate and glutamate metabolism in app/ps1 mice
publisher	Sociedad de Biología de Chile
publishDate	2018
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602018000100218
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Electroacupuncture ameliorate learning and memory by improving N -acetylaspartate and glutamate metabolism in APP/PS1 mice

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