Thiamine deficiency contributes to synapse and neural circuit defects

Abstract Background: The previous studies have demonstrated the reduction of thiamine diphosphate is specific to Alzheimer's disease (AD) and causal factor of brain glucose hypometabolism, which is considered as a neurodegenerative index of AD and closely correlates with the degree of cognitiv...

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Autores principales:	Yu,Qiujian, Liu,Huimin, Sang,Shaoming, Chen,Lulan, Zhao,Yingya, Wang,Yun, Zhong,Chunjiu
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2018
Materias:	Thiamine deficiency Synaptic dysfunction Amyloid-β Alzheimer's disease
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602018000100230
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spelling	oai:scielo:S0716-976020180001002302018-10-18Thiamine deficiency contributes to synapse and neural circuit defectsYu,QiujianLiu,HuiminSang,ShaomingChen,LulanZhao,YingyaWang,YunZhong,Chunjiu Thiamine deficiency Synaptic dysfunction Amyloid-β Alzheimer's disease Abstract Background: The previous studies have demonstrated the reduction of thiamine diphosphate is specific to Alzheimer's disease (AD) and causal factor of brain glucose hypometabolism, which is considered as a neurodegenerative index of AD and closely correlates with the degree of cognitive impairment. The reduction of thiamine diphosphate may contribute to the dysfunction of synapses and neural circuits, finally leading to cognitive decline. Results: To demonstrate this hypothesis, we established abnormalities in the glucose metabolism utilizing thiamine deficiency in vitro and in vivo, and we found dramatically reduced dendrite spine density. We further detected lowered excitatory neurotransmission and impaired hippocampal long-term potentiation, which are induced by TPK RNAi in vitro. Importantly, via treatment with benfotiamine, Aβ induced spines density decrease was considerably ameliorated. Conclusions: These results revealed that thiamine deficiency contributed to synaptic dysfunction which strongly related to AD pathogenesis. Our results provide new insights into pathogenesis of synaptic and neuronal dysfunction in AD.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.51 20182018-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602018000100230en10.1186/s40659-018-0184-5
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Thiamine deficiency Synaptic dysfunction Amyloid-β Alzheimer's disease
spellingShingle	Thiamine deficiency Synaptic dysfunction Amyloid-β Alzheimer's disease Yu,Qiujian Liu,Huimin Sang,Shaoming Chen,Lulan Zhao,Yingya Wang,Yun Zhong,Chunjiu Thiamine deficiency contributes to synapse and neural circuit defects
description	Abstract Background: The previous studies have demonstrated the reduction of thiamine diphosphate is specific to Alzheimer's disease (AD) and causal factor of brain glucose hypometabolism, which is considered as a neurodegenerative index of AD and closely correlates with the degree of cognitive impairment. The reduction of thiamine diphosphate may contribute to the dysfunction of synapses and neural circuits, finally leading to cognitive decline. Results: To demonstrate this hypothesis, we established abnormalities in the glucose metabolism utilizing thiamine deficiency in vitro and in vivo, and we found dramatically reduced dendrite spine density. We further detected lowered excitatory neurotransmission and impaired hippocampal long-term potentiation, which are induced by TPK RNAi in vitro. Importantly, via treatment with benfotiamine, Aβ induced spines density decrease was considerably ameliorated. Conclusions: These results revealed that thiamine deficiency contributed to synaptic dysfunction which strongly related to AD pathogenesis. Our results provide new insights into pathogenesis of synaptic and neuronal dysfunction in AD.
author	Yu,Qiujian Liu,Huimin Sang,Shaoming Chen,Lulan Zhao,Yingya Wang,Yun Zhong,Chunjiu
author_facet	Yu,Qiujian Liu,Huimin Sang,Shaoming Chen,Lulan Zhao,Yingya Wang,Yun Zhong,Chunjiu
author_sort	Yu,Qiujian
title	Thiamine deficiency contributes to synapse and neural circuit defects
title_short	Thiamine deficiency contributes to synapse and neural circuit defects
title_full	Thiamine deficiency contributes to synapse and neural circuit defects
title_fullStr	Thiamine deficiency contributes to synapse and neural circuit defects
title_full_unstemmed	Thiamine deficiency contributes to synapse and neural circuit defects
title_sort	thiamine deficiency contributes to synapse and neural circuit defects
publisher	Sociedad de Biología de Chile
publishDate	2018
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602018000100230
work_keys_str_mv	AT yuqiujian thiaminedeficiencycontributestosynapseandneuralcircuitdefects AT liuhuimin thiaminedeficiencycontributestosynapseandneuralcircuitdefects AT sangshaoming thiaminedeficiencycontributestosynapseandneuralcircuitdefects AT chenlulan thiaminedeficiencycontributestosynapseandneuralcircuitdefects AT zhaoyingya thiaminedeficiencycontributestosynapseandneuralcircuitdefects AT wangyun thiaminedeficiencycontributestosynapseandneuralcircuitdefects AT zhongchunjiu thiaminedeficiencycontributestosynapseandneuralcircuitdefects
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Thiamine deficiency contributes to synapse and neural circuit defects

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