Effects of vagotomy on cardiovascular and heart rate variability alterations following chronic normobaric hypoxia in adult rabbits

Abstract Background: chronic hypoxia increases basal ventilation and pulmonary vascular resistance, with variable changes in arterial blood pressure and heart rate, but it's impact on heart rate variability and autonomic regulation have been less well examined. We studied changes in arterial b...

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Autores principales:	Alcayaga,Julio, Del-Rio,Rodrigo, Moya,Esteban A., Freire,Matías, Iturriaga,Rodrigo
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2018
Materias:	Heart rate variability Chronic normobaric hypoxia Cardiovascular regulation Sympathetic control Vagal activity Poincaré plot Spectral components
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602018000100247
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spelling	oai:scielo:S0716-976020180001002472019-06-24Effects of vagotomy on cardiovascular and heart rate variability alterations following chronic normobaric hypoxia in adult rabbitsAlcayaga,JulioDel-Rio,RodrigoMoya,Esteban A.Freire,MatíasIturriaga,Rodrigo Heart rate variability Chronic normobaric hypoxia Cardiovascular regulation Sympathetic control Vagal activity Poincaré plot Spectral components Abstract Background: chronic hypoxia increases basal ventilation and pulmonary vascular resistance, with variable changes in arterial blood pressure and heart rate, but it's impact on heart rate variability and autonomic regulation have been less well examined. We studied changes in arterial blood pressure, heart rate and heart rate variability (HRV) in rabbits subjected to chronic normobaric hypoxia (CNH; PB ~ 719 mmHg; FIO2 ~ 9.2%) for 14 days and assess the effect of autonomic control by acute bilateral vagal denervation. Results: exposure to CNH stalled animal weight gain and increased the hematocrit, without affecting heart rate or arterial blood pressure. Nevertheless, Poincaré plots of the electrocardiographic R-R intervals showed a reduced distribution parallel to the line of identity, which interpreted as reduced long-term HRV. In the frequency domain, CNH reduced the very-low- (< 0.2 Hz) and high-frequency components (> 0.8 Hz) of the R-R spectrograms and produced a prominent component in the low-frequency component (0.2-0.5 Hz) of the power spectrum. In control and CNH exposed rabbits, bilateral vagotomy had no apparent effect on the short- and long-term HRV in the Poincaré plots. However, bilateral vagotomy differentially affected higher-frequency components (> 0.8 Hz); reducing it in control animals without modifying it in CNH-exposed rabbits. Conclusions: These results suggest that CNH exposure shifts the autonomic balance of heart rate towards a sympathetic predominance without modifying resting heart rate or arterial blood pressure.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.51 20182018-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602018000100247en10.1186/s40659-018-0207-2
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Heart rate variability Chronic normobaric hypoxia Cardiovascular regulation Sympathetic control Vagal activity Poincaré plot Spectral components
spellingShingle	Heart rate variability Chronic normobaric hypoxia Cardiovascular regulation Sympathetic control Vagal activity Poincaré plot Spectral components Alcayaga,Julio Del-Rio,Rodrigo Moya,Esteban A. Freire,Matías Iturriaga,Rodrigo Effects of vagotomy on cardiovascular and heart rate variability alterations following chronic normobaric hypoxia in adult rabbits
description	Abstract Background: chronic hypoxia increases basal ventilation and pulmonary vascular resistance, with variable changes in arterial blood pressure and heart rate, but it's impact on heart rate variability and autonomic regulation have been less well examined. We studied changes in arterial blood pressure, heart rate and heart rate variability (HRV) in rabbits subjected to chronic normobaric hypoxia (CNH; PB ~ 719 mmHg; FIO2 ~ 9.2%) for 14 days and assess the effect of autonomic control by acute bilateral vagal denervation. Results: exposure to CNH stalled animal weight gain and increased the hematocrit, without affecting heart rate or arterial blood pressure. Nevertheless, Poincaré plots of the electrocardiographic R-R intervals showed a reduced distribution parallel to the line of identity, which interpreted as reduced long-term HRV. In the frequency domain, CNH reduced the very-low- (< 0.2 Hz) and high-frequency components (> 0.8 Hz) of the R-R spectrograms and produced a prominent component in the low-frequency component (0.2-0.5 Hz) of the power spectrum. In control and CNH exposed rabbits, bilateral vagotomy had no apparent effect on the short- and long-term HRV in the Poincaré plots. However, bilateral vagotomy differentially affected higher-frequency components (> 0.8 Hz); reducing it in control animals without modifying it in CNH-exposed rabbits. Conclusions: These results suggest that CNH exposure shifts the autonomic balance of heart rate towards a sympathetic predominance without modifying resting heart rate or arterial blood pressure.
author	Alcayaga,Julio Del-Rio,Rodrigo Moya,Esteban A. Freire,Matías Iturriaga,Rodrigo
author_facet	Alcayaga,Julio Del-Rio,Rodrigo Moya,Esteban A. Freire,Matías Iturriaga,Rodrigo
author_sort	Alcayaga,Julio
title	Effects of vagotomy on cardiovascular and heart rate variability alterations following chronic normobaric hypoxia in adult rabbits
title_short	Effects of vagotomy on cardiovascular and heart rate variability alterations following chronic normobaric hypoxia in adult rabbits
title_full	Effects of vagotomy on cardiovascular and heart rate variability alterations following chronic normobaric hypoxia in adult rabbits
title_fullStr	Effects of vagotomy on cardiovascular and heart rate variability alterations following chronic normobaric hypoxia in adult rabbits
title_full_unstemmed	Effects of vagotomy on cardiovascular and heart rate variability alterations following chronic normobaric hypoxia in adult rabbits
title_sort	effects of vagotomy on cardiovascular and heart rate variability alterations following chronic normobaric hypoxia in adult rabbits
publisher	Sociedad de Biología de Chile
publishDate	2018
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602018000100247
work_keys_str_mv	AT alcayagajulio effectsofvagotomyoncardiovascularandheartratevariabilityalterationsfollowingchronicnormobarichypoxiainadultrabbits AT delriorodrigo effectsofvagotomyoncardiovascularandheartratevariabilityalterationsfollowingchronicnormobarichypoxiainadultrabbits AT moyaestebana effectsofvagotomyoncardiovascularandheartratevariabilityalterationsfollowingchronicnormobarichypoxiainadultrabbits AT freirematias effectsofvagotomyoncardiovascularandheartratevariabilityalterationsfollowingchronicnormobarichypoxiainadultrabbits AT iturriagarodrigo effectsofvagotomyoncardiovascularandheartratevariabilityalterationsfollowingchronicnormobarichypoxiainadultrabbits
_version_	1718441580056018944

Effects of vagotomy on cardiovascular and heart rate variability alterations following chronic normobaric hypoxia in adult rabbits

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