Involvement of K+ATP and Ca2+ channels in hydrogen sulfide-suppressed ageing of porcine oocytes

Abstract Background: Hydrogen sulfide has been shown to improve the quality of oocytes destined for in vitro fertilization. Although hydrogen sulfide is capable of modulating ion channel activity in somatic cells, the role of hydrogen sulfide in gametes and embryos remains unknown. Our observations...

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Autores principales:	Nevoral,Jan, Zalmanova,Tereza, Hoskova,Kristyna, Stiavnicka,Miriam, Hosek,Petr, Petelak,Ales, Petr,Jaroslav
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2018
Materias:	Oocyte Gasotransmitter Hydrogen sulfide Ion channel Oocyte ageing
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602018000100401
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spelling	oai:scielo:S0716-976020180001004012018-12-05Involvement of K+ATP and Ca2+ channels in hydrogen sulfide-suppressed ageing of porcine oocytesNevoral,JanZalmanova,TerezaHoskova,KristynaStiavnicka,MiriamHosek,PetrPetelak,AlesPetr,Jaroslav Oocyte Gasotransmitter Hydrogen sulfide Ion channel Oocyte ageing Abstract Background: Hydrogen sulfide has been shown to improve the quality of oocytes destined for in vitro fertilization. Although hydrogen sulfide is capable of modulating ion channel activity in somatic cells, the role of hydrogen sulfide in gametes and embryos remains unknown. Our observations confirmed the hypothesis that the KATP and L-type Ca2+ ion channels play roles in porcine oocyte ageing and revealed a plausible contribution of hydrogen sulfide to the modulation of ion channel activity. Results: We confirmed the benefits of the activation and suppression of the KATP and L-type Ca2+ ion channels, respectively, for the preservation of oocyte quality. Conclusions: Our experiments identified hydrogen sulfide as promoting the desired ion channel activity, with the capacity to protect porcine oocytes against cell death. Further experiments are needed to determine the exact mechanism of hydrogen sulfide in gametes and embryos.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.51 20182018-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602018000100401en10.1186/s40659-018-0187-2
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Oocyte Gasotransmitter Hydrogen sulfide Ion channel Oocyte ageing
spellingShingle	Oocyte Gasotransmitter Hydrogen sulfide Ion channel Oocyte ageing Nevoral,Jan Zalmanova,Tereza Hoskova,Kristyna Stiavnicka,Miriam Hosek,Petr Petelak,Ales Petr,Jaroslav Involvement of K+ATP and Ca2+ channels in hydrogen sulfide-suppressed ageing of porcine oocytes
description	Abstract Background: Hydrogen sulfide has been shown to improve the quality of oocytes destined for in vitro fertilization. Although hydrogen sulfide is capable of modulating ion channel activity in somatic cells, the role of hydrogen sulfide in gametes and embryos remains unknown. Our observations confirmed the hypothesis that the KATP and L-type Ca2+ ion channels play roles in porcine oocyte ageing and revealed a plausible contribution of hydrogen sulfide to the modulation of ion channel activity. Results: We confirmed the benefits of the activation and suppression of the KATP and L-type Ca2+ ion channels, respectively, for the preservation of oocyte quality. Conclusions: Our experiments identified hydrogen sulfide as promoting the desired ion channel activity, with the capacity to protect porcine oocytes against cell death. Further experiments are needed to determine the exact mechanism of hydrogen sulfide in gametes and embryos.
author	Nevoral,Jan Zalmanova,Tereza Hoskova,Kristyna Stiavnicka,Miriam Hosek,Petr Petelak,Ales Petr,Jaroslav
author_facet	Nevoral,Jan Zalmanova,Tereza Hoskova,Kristyna Stiavnicka,Miriam Hosek,Petr Petelak,Ales Petr,Jaroslav
author_sort	Nevoral,Jan
title	Involvement of K+ATP and Ca2+ channels in hydrogen sulfide-suppressed ageing of porcine oocytes
title_short	Involvement of K+ATP and Ca2+ channels in hydrogen sulfide-suppressed ageing of porcine oocytes
title_full	Involvement of K+ATP and Ca2+ channels in hydrogen sulfide-suppressed ageing of porcine oocytes
title_fullStr	Involvement of K+ATP and Ca2+ channels in hydrogen sulfide-suppressed ageing of porcine oocytes
title_full_unstemmed	Involvement of K+ATP and Ca2+ channels in hydrogen sulfide-suppressed ageing of porcine oocytes
title_sort	involvement of k+atp and ca2+ channels in hydrogen sulfide-suppressed ageing of porcine oocytes
publisher	Sociedad de Biología de Chile
publishDate	2018
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602018000100401
work_keys_str_mv	AT nevoraljan involvementofkatpandca2channelsinhydrogensulfidesuppressedageingofporcineoocytes AT zalmanovatereza involvementofkatpandca2channelsinhydrogensulfidesuppressedageingofporcineoocytes AT hoskovakristyna involvementofkatpandca2channelsinhydrogensulfidesuppressedageingofporcineoocytes AT stiavnickamiriam involvementofkatpandca2channelsinhydrogensulfidesuppressedageingofporcineoocytes AT hosekpetr involvementofkatpandca2channelsinhydrogensulfidesuppressedageingofporcineoocytes AT petelakales involvementofkatpandca2channelsinhydrogensulfidesuppressedageingofporcineoocytes AT petrjaroslav involvementofkatpandca2channelsinhydrogensulfidesuppressedageingofporcineoocytes
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Involvement of K+ATP and Ca2+ channels in hydrogen sulfide-suppressed ageing of porcine oocytes

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