A Nexus model of cellular transition in cancer
Abstract The exact cause of cancer is one of the most immutable medical questions of the century. Cancer as an evolutionary disease must have a purpose and understanding the purpose is more important than decoding the cause. The model of cancer proposed herein, provides a link between the cellular b...
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| Lenguaje: | English |
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Sociedad de Biología de Chile
2018
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oai:scielo:S0716-976020180001005022018-09-05A Nexus model of cellular transition in cancerYadav,MukeshChatterjee,PayalTolani,SimranKulkarni,JayaMulye,MeenakshiChauhan,NamrataSakhi,AditiGorey,Sakshi Cancer The Nexus model Biochemical stress Epigenetics Mutations Genetics Abstract The exact cause of cancer is one of the most immutable medical questions of the century. Cancer as an evolutionary disease must have a purpose and understanding the purpose is more important than decoding the cause. The model of cancer proposed herein, provides a link between the cellular biochemistry and cellular genetics of cancer evolution. We thus call this model as the “Nexus model” of cancer. The Nexus model is an effort to identify the most apparent route to the disease. We have tried to utilize existing cancer literature to identify the most plausible causes of cellular transition in cancer, where the primary cancer-causing agents (physical, chemical or biological) act as inducing factors to produce cellular impeders. These cellular impeders are further linked to the Nexus. The Nexus then generates codes for epigenetics and genetics in cancer development.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.51 20182018-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602018000100502en10.1186/s40659-018-0173-8 |
| institution |
Scielo Chile |
| collection |
Scielo Chile |
| language |
English |
| topic |
Cancer The Nexus model Biochemical stress Epigenetics Mutations Genetics |
| spellingShingle |
Cancer The Nexus model Biochemical stress Epigenetics Mutations Genetics Yadav,Mukesh Chatterjee,Payal Tolani,Simran Kulkarni,Jaya Mulye,Meenakshi Chauhan,Namrata Sakhi,Aditi Gorey,Sakshi A Nexus model of cellular transition in cancer |
| description |
Abstract The exact cause of cancer is one of the most immutable medical questions of the century. Cancer as an evolutionary disease must have a purpose and understanding the purpose is more important than decoding the cause. The model of cancer proposed herein, provides a link between the cellular biochemistry and cellular genetics of cancer evolution. We thus call this model as the “Nexus model” of cancer. The Nexus model is an effort to identify the most apparent route to the disease. We have tried to utilize existing cancer literature to identify the most plausible causes of cellular transition in cancer, where the primary cancer-causing agents (physical, chemical or biological) act as inducing factors to produce cellular impeders. These cellular impeders are further linked to the Nexus. The Nexus then generates codes for epigenetics and genetics in cancer development. |
| author |
Yadav,Mukesh Chatterjee,Payal Tolani,Simran Kulkarni,Jaya Mulye,Meenakshi Chauhan,Namrata Sakhi,Aditi Gorey,Sakshi |
| author_facet |
Yadav,Mukesh Chatterjee,Payal Tolani,Simran Kulkarni,Jaya Mulye,Meenakshi Chauhan,Namrata Sakhi,Aditi Gorey,Sakshi |
| author_sort |
Yadav,Mukesh |
| title |
A Nexus model of cellular transition in cancer |
| title_short |
A Nexus model of cellular transition in cancer |
| title_full |
A Nexus model of cellular transition in cancer |
| title_fullStr |
A Nexus model of cellular transition in cancer |
| title_full_unstemmed |
A Nexus model of cellular transition in cancer |
| title_sort |
nexus model of cellular transition in cancer |
| publisher |
Sociedad de Biología de Chile |
| publishDate |
2018 |
| url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602018000100502 |
| work_keys_str_mv |
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