ErbB1 and ErbB3 co-over expression as a prognostic factor in gastric cancer

Abstract Background: Epidermal growth factor receptor family members such as ErbB1 and ErbB3 are involved in tumor progression and metastasis. Although, there are various reports about the prognostic value of EGFR members separately in gastric cancer, there is not any report about the probable corr...

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Autores principales:	Moghbeli,Meysam, Makhdoumi,Yasha, Delgosha,Mehrdad Soltani, Aarabi,Azadeh, Dadkhah,Ezzat, Memar,Bahram, Abdollahi,Abbas, Abbaszadegan,Mohammad Reza
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2019
Materias:	Gastric cancer EGFR HER3 Prognosis Targeted therapy
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602019000100202
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spelling	oai:scielo:S0716-976020190001002022019-10-10ErbB1 and ErbB3 co-over expression as a prognostic factor in gastric cancerMoghbeli,MeysamMakhdoumi,YashaDelgosha,Mehrdad SoltaniAarabi,AzadehDadkhah,EzzatMemar,BahramAbdollahi,AbbasAbbaszadegan,Mohammad Reza Gastric cancer EGFR HER3 Prognosis Targeted therapy Abstract Background: Epidermal growth factor receptor family members such as ErbB1 and ErbB3 are involved in tumor progression and metastasis. Although, there are various reports about the prognostic value of EGFR members separately in gastric cancer, there is not any report about the probable correlation between ErbB1 and ErbB3 co-expression and gastric cancer prognosis. In present study, we assessed the correlation between ErbB1 and ErbB3 co-overexpression (in the level of mRNA and protein expression) and gastric cancer prognosis for the first time. Methods: ErbB1 and ErbB3 expressions were analyzed by immunohistochemistry and real-time PCR in 50 patients with gastric cancer. Parametric correlations were done between the ErbB1 and ErbB3 expression and clinicopathological features. Multivariate and logistic regression analyses were also done to assess the roles of ErbB1 and ErbB3 in tumor prognosis and survival. Results: There were significant correlations between ErbB1/ErbB3 co-overexpression and tumor size (p = 0.026), macroscopic features (p < 0.05), tumor differentiation (p < 0.05), stage of tumor (p < 0.05), and recurrence (p < 0.05). Moreover, ErbB1/ErbB3 co-overexpression may predict the survival status of patients (p < 0.05). Conclusion: ErbB1 and ErbB3 co-overexpression is accompanied with the poor prognosis and can be used efficiently in targeted therapy of gastric cancer patients.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.52 20192019-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602019000100202en10.1186/s40659-018-0208-1
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Gastric cancer EGFR HER3 Prognosis Targeted therapy
spellingShingle	Gastric cancer EGFR HER3 Prognosis Targeted therapy Moghbeli,Meysam Makhdoumi,Yasha Delgosha,Mehrdad Soltani Aarabi,Azadeh Dadkhah,Ezzat Memar,Bahram Abdollahi,Abbas Abbaszadegan,Mohammad Reza ErbB1 and ErbB3 co-over expression as a prognostic factor in gastric cancer
description	Abstract Background: Epidermal growth factor receptor family members such as ErbB1 and ErbB3 are involved in tumor progression and metastasis. Although, there are various reports about the prognostic value of EGFR members separately in gastric cancer, there is not any report about the probable correlation between ErbB1 and ErbB3 co-expression and gastric cancer prognosis. In present study, we assessed the correlation between ErbB1 and ErbB3 co-overexpression (in the level of mRNA and protein expression) and gastric cancer prognosis for the first time. Methods: ErbB1 and ErbB3 expressions were analyzed by immunohistochemistry and real-time PCR in 50 patients with gastric cancer. Parametric correlations were done between the ErbB1 and ErbB3 expression and clinicopathological features. Multivariate and logistic regression analyses were also done to assess the roles of ErbB1 and ErbB3 in tumor prognosis and survival. Results: There were significant correlations between ErbB1/ErbB3 co-overexpression and tumor size (p = 0.026), macroscopic features (p < 0.05), tumor differentiation (p < 0.05), stage of tumor (p < 0.05), and recurrence (p < 0.05). Moreover, ErbB1/ErbB3 co-overexpression may predict the survival status of patients (p < 0.05). Conclusion: ErbB1 and ErbB3 co-overexpression is accompanied with the poor prognosis and can be used efficiently in targeted therapy of gastric cancer patients.
author	Moghbeli,Meysam Makhdoumi,Yasha Delgosha,Mehrdad Soltani Aarabi,Azadeh Dadkhah,Ezzat Memar,Bahram Abdollahi,Abbas Abbaszadegan,Mohammad Reza
author_facet	Moghbeli,Meysam Makhdoumi,Yasha Delgosha,Mehrdad Soltani Aarabi,Azadeh Dadkhah,Ezzat Memar,Bahram Abdollahi,Abbas Abbaszadegan,Mohammad Reza
author_sort	Moghbeli,Meysam
title	ErbB1 and ErbB3 co-over expression as a prognostic factor in gastric cancer
title_short	ErbB1 and ErbB3 co-over expression as a prognostic factor in gastric cancer
title_full	ErbB1 and ErbB3 co-over expression as a prognostic factor in gastric cancer
title_fullStr	ErbB1 and ErbB3 co-over expression as a prognostic factor in gastric cancer
title_full_unstemmed	ErbB1 and ErbB3 co-over expression as a prognostic factor in gastric cancer
title_sort	erbb1 and erbb3 co-over expression as a prognostic factor in gastric cancer
publisher	Sociedad de Biología de Chile
publishDate	2019
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602019000100202
work_keys_str_mv	AT moghbelimeysam erbb1anderbb3cooverexpressionasaprognosticfactoringastriccancer AT makhdoumiyasha erbb1anderbb3cooverexpressionasaprognosticfactoringastriccancer AT delgoshamehrdadsoltani erbb1anderbb3cooverexpressionasaprognosticfactoringastriccancer AT aarabiazadeh erbb1anderbb3cooverexpressionasaprognosticfactoringastriccancer AT dadkhahezzat erbb1anderbb3cooverexpressionasaprognosticfactoringastriccancer AT memarbahram erbb1anderbb3cooverexpressionasaprognosticfactoringastriccancer AT abdollahiabbas erbb1anderbb3cooverexpressionasaprognosticfactoringastriccancer AT abbaszadeganmohammadreza erbb1anderbb3cooverexpressionasaprognosticfactoringastriccancer
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ErbB1 and ErbB3 co-over expression as a prognostic factor in gastric cancer

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