Intestinal transcriptional profiling reveals fava bean-induced immune response in DBA/1 mice

Abstract Background: Fava beans (FBs) have long been used as food, and their principal disadvantage is derived from their haemotoxicity. We hypothesized that FB ingestion alters the intestinal gene expression pattern, thereby inducing an immune response. Results: In-depth sequence analysis identif...

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Auteurs principaux:	Du,Guankui, Xiao,Man, Zhu,Qiwei, Zhou,Chen, Wang,Ao, Cai,Wangwei
Langue:	English
Publié:	Sociedad de Biología de Chile 2019
Sujets:	Fava beans Differentially expressed genes DEGs Immune response Total IgE Histamine
Accès en ligne:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602019000100207
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spelling	oai:scielo:S0716-976020190001002072019-10-10Intestinal transcriptional profiling reveals fava bean-induced immune response in DBA/1 miceDu,GuankuiXiao,ManZhu,QiweiZhou,ChenWang,AoCai,Wangwei Fava beans Differentially expressed genes DEGs Immune response Total IgE Histamine Abstract Background: Fava beans (FBs) have long been used as food, and their principal disadvantage is derived from their haemotoxicity. We hypothesized that FB ingestion alters the intestinal gene expression pattern, thereby inducing an immune response. Results: In-depth sequence analysis identified 769 differentially expressed genes (DEGs) associated with the intestine in FB-treated DBA/1 mouse intestines. The identified genes were shown to be associated with biological processes (such as response to stimulus and immune system processes), human disease pathways (such as infectious diseases, endocrine and metabolic diseases, and immune diseases), and organismal system pathways (such as the digestive system, endocrine system, environmental adaptation, and immune system). Moreover, plasma total immunoglobulin E (IgE), histamine, interleukin (IL)-4 and IL-13 levels were significantly increased when the mice were treated with FBs. Conclusions: These results demonstrated that FBs affect the intestinal immune response and IgE and cytokine secretion in DBA/1 mice.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.52 20192019-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602019000100207en10.1186/s40659-019-0216-9
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Fava beans Differentially expressed genes DEGs Immune response Total IgE Histamine
spellingShingle	Fava beans Differentially expressed genes DEGs Immune response Total IgE Histamine Du,Guankui Xiao,Man Zhu,Qiwei Zhou,Chen Wang,Ao Cai,Wangwei Intestinal transcriptional profiling reveals fava bean-induced immune response in DBA/1 mice
description	Abstract Background: Fava beans (FBs) have long been used as food, and their principal disadvantage is derived from their haemotoxicity. We hypothesized that FB ingestion alters the intestinal gene expression pattern, thereby inducing an immune response. Results: In-depth sequence analysis identified 769 differentially expressed genes (DEGs) associated with the intestine in FB-treated DBA/1 mouse intestines. The identified genes were shown to be associated with biological processes (such as response to stimulus and immune system processes), human disease pathways (such as infectious diseases, endocrine and metabolic diseases, and immune diseases), and organismal system pathways (such as the digestive system, endocrine system, environmental adaptation, and immune system). Moreover, plasma total immunoglobulin E (IgE), histamine, interleukin (IL)-4 and IL-13 levels were significantly increased when the mice were treated with FBs. Conclusions: These results demonstrated that FBs affect the intestinal immune response and IgE and cytokine secretion in DBA/1 mice.
author	Du,Guankui Xiao,Man Zhu,Qiwei Zhou,Chen Wang,Ao Cai,Wangwei
author_facet	Du,Guankui Xiao,Man Zhu,Qiwei Zhou,Chen Wang,Ao Cai,Wangwei
author_sort	Du,Guankui
title	Intestinal transcriptional profiling reveals fava bean-induced immune response in DBA/1 mice
title_short	Intestinal transcriptional profiling reveals fava bean-induced immune response in DBA/1 mice
title_full	Intestinal transcriptional profiling reveals fava bean-induced immune response in DBA/1 mice
title_fullStr	Intestinal transcriptional profiling reveals fava bean-induced immune response in DBA/1 mice
title_full_unstemmed	Intestinal transcriptional profiling reveals fava bean-induced immune response in DBA/1 mice
title_sort	intestinal transcriptional profiling reveals fava bean-induced immune response in dba/1 mice
publisher	Sociedad de Biología de Chile
publishDate	2019
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602019000100207
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_version_	1718441585254858752

Intestinal transcriptional profiling reveals fava bean-induced immune response in DBA/1 mice

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