TFAP2C increases cell proliferation by downregulating GADD45B and PMAIP1 in non-small cell lung cancer cells

Abstract Background: Non-small cell lung cancer (NSCLC) is one of the leading causes of death in the world. NSCLC diagnosed at an early stage can be highly curable with a positive prognosis, but biomarker limitations make it difficult to diagnose lung cancer at an early stage. To identify biomarker...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Do,Hyunhee, Kim,Dain, Kang,JiHoon, Son,Beomseok, Seo,Danbi, Youn,HyeSook, Youn,BuHyun, Kim,Wanyeon
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2019
Materias:	TFAP2C Tumor suppressor GADD45B PMAIP1 Lung tumorigenesis
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602019000100233
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:scielo:S0716-97602019000100233
record_format	dspace
spelling	oai:scielo:S0716-976020190001002332019-10-10TFAP2C increases cell proliferation by downregulating GADD45B and PMAIP1 in non-small cell lung cancer cellsDo,HyunheeKim,DainKang,JiHoonSon,BeomseokSeo,DanbiYoun,HyeSookYoun,BuHyunKim,Wanyeon TFAP2C Tumor suppressor GADD45B PMAIP1 Lung tumorigenesis Abstract Background: Non-small cell lung cancer (NSCLC) is one of the leading causes of death in the world. NSCLC diagnosed at an early stage can be highly curable with a positive prognosis, but biomarker limitations make it difficult to diagnose lung cancer at an early stage. To identify biomarkers for lung cancer development, we previously focused on the oncogenic roles of transcription factor TFAP2C in lung cancers and revealed the molecular mechanism of several oncogenes in lung tumorigenesis based on TFAP2C-related microarray analysis. Results: In this study, we analyzed microarray data to identify tumor suppressor genes and nine genes downregulated by TFAP2C were screened. Among the nine genes, we focused on growth arrest and DNA-damage-inducible beta (GADD45B) and phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1) as representative TFAP2C-regulated tumor suppressor genes. It was observed that overexpressed TFAP2C resulted in inhibition of GADD45B and PMAIP1 expressions at both the mRNA and protein levels in NSCLC cells. In addition, downregulation of GADD45B and PMAIP1 by TFAP2C promoted cell proliferation and cell motility, which are closely associated with NSCLC tumorigenesis. Conclusion: This study indicates that GADD45B and PMAIP1 could be promising tumor suppressors for NSCLC and might be useful as prognostic markers for use in NSCLC therapy.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.52 20192019-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602019000100233en10.1186/s40659-019-0244-5
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	TFAP2C Tumor suppressor GADD45B PMAIP1 Lung tumorigenesis
spellingShingle	TFAP2C Tumor suppressor GADD45B PMAIP1 Lung tumorigenesis Do,Hyunhee Kim,Dain Kang,JiHoon Son,Beomseok Seo,Danbi Youn,HyeSook Youn,BuHyun Kim,Wanyeon TFAP2C increases cell proliferation by downregulating GADD45B and PMAIP1 in non-small cell lung cancer cells
description	Abstract Background: Non-small cell lung cancer (NSCLC) is one of the leading causes of death in the world. NSCLC diagnosed at an early stage can be highly curable with a positive prognosis, but biomarker limitations make it difficult to diagnose lung cancer at an early stage. To identify biomarkers for lung cancer development, we previously focused on the oncogenic roles of transcription factor TFAP2C in lung cancers and revealed the molecular mechanism of several oncogenes in lung tumorigenesis based on TFAP2C-related microarray analysis. Results: In this study, we analyzed microarray data to identify tumor suppressor genes and nine genes downregulated by TFAP2C were screened. Among the nine genes, we focused on growth arrest and DNA-damage-inducible beta (GADD45B) and phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1) as representative TFAP2C-regulated tumor suppressor genes. It was observed that overexpressed TFAP2C resulted in inhibition of GADD45B and PMAIP1 expressions at both the mRNA and protein levels in NSCLC cells. In addition, downregulation of GADD45B and PMAIP1 by TFAP2C promoted cell proliferation and cell motility, which are closely associated with NSCLC tumorigenesis. Conclusion: This study indicates that GADD45B and PMAIP1 could be promising tumor suppressors for NSCLC and might be useful as prognostic markers for use in NSCLC therapy.
author	Do,Hyunhee Kim,Dain Kang,JiHoon Son,Beomseok Seo,Danbi Youn,HyeSook Youn,BuHyun Kim,Wanyeon
author_facet	Do,Hyunhee Kim,Dain Kang,JiHoon Son,Beomseok Seo,Danbi Youn,HyeSook Youn,BuHyun Kim,Wanyeon
author_sort	Do,Hyunhee
title	TFAP2C increases cell proliferation by downregulating GADD45B and PMAIP1 in non-small cell lung cancer cells
title_short	TFAP2C increases cell proliferation by downregulating GADD45B and PMAIP1 in non-small cell lung cancer cells
title_full	TFAP2C increases cell proliferation by downregulating GADD45B and PMAIP1 in non-small cell lung cancer cells
title_fullStr	TFAP2C increases cell proliferation by downregulating GADD45B and PMAIP1 in non-small cell lung cancer cells
title_full_unstemmed	TFAP2C increases cell proliferation by downregulating GADD45B and PMAIP1 in non-small cell lung cancer cells
title_sort	tfap2c increases cell proliferation by downregulating gadd45b and pmaip1 in non-small cell lung cancer cells
publisher	Sociedad de Biología de Chile
publishDate	2019
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602019000100233
work_keys_str_mv	AT dohyunhee tfap2cincreasescellproliferationbydownregulatinggadd45bandpmaip1innonsmallcelllungcancercells AT kimdain tfap2cincreasescellproliferationbydownregulatinggadd45bandpmaip1innonsmallcelllungcancercells AT kangjihoon tfap2cincreasescellproliferationbydownregulatinggadd45bandpmaip1innonsmallcelllungcancercells AT sonbeomseok tfap2cincreasescellproliferationbydownregulatinggadd45bandpmaip1innonsmallcelllungcancercells AT seodanbi tfap2cincreasescellproliferationbydownregulatinggadd45bandpmaip1innonsmallcelllungcancercells AT younhyesook tfap2cincreasescellproliferationbydownregulatinggadd45bandpmaip1innonsmallcelllungcancercells AT younbuhyun tfap2cincreasescellproliferationbydownregulatinggadd45bandpmaip1innonsmallcelllungcancercells AT kimwanyeon tfap2cincreasescellproliferationbydownregulatinggadd45bandpmaip1innonsmallcelllungcancercells
_version_	1718441592328552448

TFAP2C increases cell proliferation by downregulating GADD45B and PMAIP1 in non-small cell lung cancer cells

Ejemplares similares