Resveratrol reduces store-operated Ca2+ entry and enhances the apoptosis of fibroblast-like synoviocytes in adjuvant arthritis rats model via targeting ORAI1-STIM1 complex

Resveratrol reduces store-operated Ca2+ entry and enhances the apoptosis of fibroblast-like synoviocytes in adjuvant arthritis rats model via targeting ORAI1-STIM1 complex

Abstract Background: Resveratrol was reported to trigger the apoptosis of fibroblast-like synoviocytes In adjuvant arthritis rats but the subcellular mechanism remains unclear. Since ER stress, mitochondrial dysfunction and oxidative stress were involved in the effects of resveratrol with imbalance...

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Autores principales: Lu,Jinsen, Yang,Jiazhao, Zheng,Yongshun, Fang,Shiyuan, Chen,Xiaoyu
Lenguaje:English
Publicado: Sociedad de Biología de Chile 2019
Materias:
Resveratrol
Apoptosis
Store-operated calcium entry
STIM1
ORAI1
Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602019000100242
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