Astilbin reduces ROS accumulation and VEGF expression through Nrf2 in psoriasis-like skin disease

Abstract Background: Psoriasis is a common and intractable skin disease affecting the physical and mental health of patients. The accumulation of ROS is involved in the pathogenesis of psoriasis and antioxidants are believed to be therapeutic. This study aimed to investigate the therapeutic efficac...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Wang,Wuyuntana, Yuhai, Wang,Huan, Chasuna, Bagenna
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2019
Materias:	Astilbin ROS Nrf2 Psoriasis
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602019000100245
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:scielo:S0716-97602019000100245
record_format	dspace
spelling	oai:scielo:S0716-976020190001002452019-10-10Astilbin reduces ROS accumulation and VEGF expression through Nrf2 in psoriasis-like skin diseaseWang,WuyuntanaYuhai,Wang,HuanChasuna,Bagenna, Astilbin ROS Nrf2 Psoriasis Abstract Background: Psoriasis is a common and intractable skin disease affecting the physical and mental health of patients. The accumulation of ROS is involved in the pathogenesis of psoriasis and antioxidants are believed to be therapeutic. This study aimed to investigate the therapeutic efficacy of astilbin on ROS accumulation in psoriasis. Results: The study showed that 50 μg/ml astilbin could inhibit the growth and reduce the accumulation of ROS in HaCaT cells stimulated by IL-17 and TNF-α. Astilbin could elevate the Nrf2 accumulation in the nuclei, eventually leading to the transcriptional activation of various antioxidant proteins and reducing the expression of VEGF. Conclusions: Our results collectively suggest that astilbin could induce Nrf2 nucleus translocation, which is contribute to reduce the ROS accumulation and VEGF expression, and inhibit the proliferation of HaCaT cells.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.52 20192019-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602019000100245en10.1186/s40659-019-0255-2
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Astilbin ROS Nrf2 Psoriasis
spellingShingle	Astilbin ROS Nrf2 Psoriasis Wang,Wuyuntana Yuhai, Wang,Huan Chasuna, Bagenna, Astilbin reduces ROS accumulation and VEGF expression through Nrf2 in psoriasis-like skin disease
description	Abstract Background: Psoriasis is a common and intractable skin disease affecting the physical and mental health of patients. The accumulation of ROS is involved in the pathogenesis of psoriasis and antioxidants are believed to be therapeutic. This study aimed to investigate the therapeutic efficacy of astilbin on ROS accumulation in psoriasis. Results: The study showed that 50 μg/ml astilbin could inhibit the growth and reduce the accumulation of ROS in HaCaT cells stimulated by IL-17 and TNF-α. Astilbin could elevate the Nrf2 accumulation in the nuclei, eventually leading to the transcriptional activation of various antioxidant proteins and reducing the expression of VEGF. Conclusions: Our results collectively suggest that astilbin could induce Nrf2 nucleus translocation, which is contribute to reduce the ROS accumulation and VEGF expression, and inhibit the proliferation of HaCaT cells.
author	Wang,Wuyuntana Yuhai, Wang,Huan Chasuna, Bagenna,
author_facet	Wang,Wuyuntana Yuhai, Wang,Huan Chasuna, Bagenna,
author_sort	Wang,Wuyuntana
title	Astilbin reduces ROS accumulation and VEGF expression through Nrf2 in psoriasis-like skin disease
title_short	Astilbin reduces ROS accumulation and VEGF expression through Nrf2 in psoriasis-like skin disease
title_full	Astilbin reduces ROS accumulation and VEGF expression through Nrf2 in psoriasis-like skin disease
title_fullStr	Astilbin reduces ROS accumulation and VEGF expression through Nrf2 in psoriasis-like skin disease
title_full_unstemmed	Astilbin reduces ROS accumulation and VEGF expression through Nrf2 in psoriasis-like skin disease
title_sort	astilbin reduces ros accumulation and vegf expression through nrf2 in psoriasis-like skin disease
publisher	Sociedad de Biología de Chile
publishDate	2019
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602019000100245
work_keys_str_mv	AT wangwuyuntana astilbinreducesrosaccumulationandvegfexpressionthroughnrf2inpsoriasislikeskindisease AT yuhai astilbinreducesrosaccumulationandvegfexpressionthroughnrf2inpsoriasislikeskindisease AT wanghuan astilbinreducesrosaccumulationandvegfexpressionthroughnrf2inpsoriasislikeskindisease AT chasuna astilbinreducesrosaccumulationandvegfexpressionthroughnrf2inpsoriasislikeskindisease AT bagenna astilbinreducesrosaccumulationandvegfexpressionthroughnrf2inpsoriasislikeskindisease
_version_	1718441595543486464

Astilbin reduces ROS accumulation and VEGF expression through Nrf2 in psoriasis-like skin disease

Ejemplares similares