Rhein alleviates renal interstitial fibrosis by inhibiting tubular cell apoptosis in rats

Abstract Background: Ureteral obstruction causes injury of the renal tissues and can irreversibly progress to renal fibrosis, with atrophy and apoptosis of tubular cells. The goal of the current study was to examine the effects of rhein on the apoptosis o renal tubular cells as well as renal fibros...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Chen,Yakun, Mu,Lin, Xing,Lingling, Li,Shaomei, Fu,Shuxia
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2019
Materias:	Rhein Renal interstitial fibrosis Apoptosis Unilateral ureteral obstruction Collagen
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602019000100246
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:scielo:S0716-97602019000100246
record_format	dspace
spelling	oai:scielo:S0716-976020190001002462019-10-10Rhein alleviates renal interstitial fibrosis by inhibiting tubular cell apoptosis in ratsChen,YakunMu,LinXing,LinglingLi,ShaomeiFu,Shuxia Rhein Renal interstitial fibrosis Apoptosis Unilateral ureteral obstruction Collagen Abstract Background: Ureteral obstruction causes injury of the renal tissues and can irreversibly progress to renal fibrosis, with atrophy and apoptosis of tubular cells. The goal of the current study was to examine the effects of rhein on the apoptosis o renal tubular cells as well as renal fibrosis using a rodent model of unilateral ureteral obstruction (UUO). Methods: UUO was induced through ureteral ligation, then animals received treatments with rhein or vehicle. The control rats only received sham operation. The renal tissue was harvested 1 week after surgery for assessment of kidney fibrosis. Results: The expressions of collagen I and α-smooth muscle actin (α-SMA), as well as the severity of renal tubular apoptosis and fibrosis were time-dependently increased following UUO. Treatments with rhein partially inhibited such responses. Renal interstitial fibrosis was associated with STAT3 (signal transducer and activator of transcription 3) phosphorylation as well as altered expressions of Bax and Bcl2, both apoptosis-related proteins. Treatment with rhein also partly blocked these responses. Conclusion: These findings demonstrated that rhein mitigated apoptosis of renal tubular cell as well as renal fibrosis in a UUO rodent model. This curative effect is likely mediated via suppression of STAT3 phosphorylation.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.52 20192019-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602019000100246en10.1186/s40659-019-0257-0
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Rhein Renal interstitial fibrosis Apoptosis Unilateral ureteral obstruction Collagen
spellingShingle	Rhein Renal interstitial fibrosis Apoptosis Unilateral ureteral obstruction Collagen Chen,Yakun Mu,Lin Xing,Lingling Li,Shaomei Fu,Shuxia Rhein alleviates renal interstitial fibrosis by inhibiting tubular cell apoptosis in rats
description	Abstract Background: Ureteral obstruction causes injury of the renal tissues and can irreversibly progress to renal fibrosis, with atrophy and apoptosis of tubular cells. The goal of the current study was to examine the effects of rhein on the apoptosis o renal tubular cells as well as renal fibrosis using a rodent model of unilateral ureteral obstruction (UUO). Methods: UUO was induced through ureteral ligation, then animals received treatments with rhein or vehicle. The control rats only received sham operation. The renal tissue was harvested 1 week after surgery for assessment of kidney fibrosis. Results: The expressions of collagen I and α-smooth muscle actin (α-SMA), as well as the severity of renal tubular apoptosis and fibrosis were time-dependently increased following UUO. Treatments with rhein partially inhibited such responses. Renal interstitial fibrosis was associated with STAT3 (signal transducer and activator of transcription 3) phosphorylation as well as altered expressions of Bax and Bcl2, both apoptosis-related proteins. Treatment with rhein also partly blocked these responses. Conclusion: These findings demonstrated that rhein mitigated apoptosis of renal tubular cell as well as renal fibrosis in a UUO rodent model. This curative effect is likely mediated via suppression of STAT3 phosphorylation.
author	Chen,Yakun Mu,Lin Xing,Lingling Li,Shaomei Fu,Shuxia
author_facet	Chen,Yakun Mu,Lin Xing,Lingling Li,Shaomei Fu,Shuxia
author_sort	Chen,Yakun
title	Rhein alleviates renal interstitial fibrosis by inhibiting tubular cell apoptosis in rats
title_short	Rhein alleviates renal interstitial fibrosis by inhibiting tubular cell apoptosis in rats
title_full	Rhein alleviates renal interstitial fibrosis by inhibiting tubular cell apoptosis in rats
title_fullStr	Rhein alleviates renal interstitial fibrosis by inhibiting tubular cell apoptosis in rats
title_full_unstemmed	Rhein alleviates renal interstitial fibrosis by inhibiting tubular cell apoptosis in rats
title_sort	rhein alleviates renal interstitial fibrosis by inhibiting tubular cell apoptosis in rats
publisher	Sociedad de Biología de Chile
publishDate	2019
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602019000100246
work_keys_str_mv	AT chenyakun rheinalleviatesrenalinterstitialfibrosisbyinhibitingtubularcellapoptosisinrats AT mulin rheinalleviatesrenalinterstitialfibrosisbyinhibitingtubularcellapoptosisinrats AT xinglingling rheinalleviatesrenalinterstitialfibrosisbyinhibitingtubularcellapoptosisinrats AT lishaomei rheinalleviatesrenalinterstitialfibrosisbyinhibitingtubularcellapoptosisinrats AT fushuxia rheinalleviatesrenalinterstitialfibrosisbyinhibitingtubularcellapoptosisinrats
_version_	1718441595816116224

Rhein alleviates renal interstitial fibrosis by inhibiting tubular cell apoptosis in rats

Ejemplares similares