Molecular aspects of the teratogenesis of rubella virus

Abstract Rubella or German measles is an infection caused by rubella virus (RV). Infection of children and adults is usually characterized by a mild exanthematous febrile illness. However, RV is a major cause of birth defects and fetal death following infection in pregnant women. RV is a teratogen a...

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Autores principales:	George,Suji, Viswanathan,Rajlakshmi, Sapkal,Gajanan N.
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2019
Materias:	Rubella Teratogenesis Apoptosis Mitochondria
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602019000100501
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spelling	oai:scielo:S0716-976020190001005012019-10-10Molecular aspects of the teratogenesis of rubella virusGeorge,SujiViswanathan,RajlakshmiSapkal,Gajanan N. Rubella Teratogenesis Apoptosis Mitochondria Abstract Rubella or German measles is an infection caused by rubella virus (RV). Infection of children and adults is usually characterized by a mild exanthematous febrile illness. However, RV is a major cause of birth defects and fetal death following infection in pregnant women. RV is a teratogen and is a major cause of public health concern as there are more than 100,000 cases of congenital rubella syndrome (CRS) estimated to occur every year. Several lines of evidence in the field of molecular biology of RV have provided deeper insights into the teratogenesis process. The damage to the growing fetus in infected mothers is multifactorial, arising from a combination of cellular damage, as well as its effect on the dividing cells. This review focuses on the findings in the molecular biology of RV, with special emphasis on the mitochondrial, cytoskeleton and the gene expression changes. Further, the review addresses in detail, the role of apoptosis in the teratogenesis process.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.52 20192019-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602019000100501en10.1186/s40659-019-0254-3
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Rubella Teratogenesis Apoptosis Mitochondria
spellingShingle	Rubella Teratogenesis Apoptosis Mitochondria George,Suji Viswanathan,Rajlakshmi Sapkal,Gajanan N. Molecular aspects of the teratogenesis of rubella virus
description	Abstract Rubella or German measles is an infection caused by rubella virus (RV). Infection of children and adults is usually characterized by a mild exanthematous febrile illness. However, RV is a major cause of birth defects and fetal death following infection in pregnant women. RV is a teratogen and is a major cause of public health concern as there are more than 100,000 cases of congenital rubella syndrome (CRS) estimated to occur every year. Several lines of evidence in the field of molecular biology of RV have provided deeper insights into the teratogenesis process. The damage to the growing fetus in infected mothers is multifactorial, arising from a combination of cellular damage, as well as its effect on the dividing cells. This review focuses on the findings in the molecular biology of RV, with special emphasis on the mitochondrial, cytoskeleton and the gene expression changes. Further, the review addresses in detail, the role of apoptosis in the teratogenesis process.
author	George,Suji Viswanathan,Rajlakshmi Sapkal,Gajanan N.
author_facet	George,Suji Viswanathan,Rajlakshmi Sapkal,Gajanan N.
author_sort	George,Suji
title	Molecular aspects of the teratogenesis of rubella virus
title_short	Molecular aspects of the teratogenesis of rubella virus
title_full	Molecular aspects of the teratogenesis of rubella virus
title_fullStr	Molecular aspects of the teratogenesis of rubella virus
title_full_unstemmed	Molecular aspects of the teratogenesis of rubella virus
title_sort	molecular aspects of the teratogenesis of rubella virus
publisher	Sociedad de Biología de Chile
publishDate	2019
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602019000100501
work_keys_str_mv	AT georgesuji molecularaspectsoftheteratogenesisofrubellavirus AT viswanathanrajlakshmi molecularaspectsoftheteratogenesisofrubellavirus AT sapkalgajanann molecularaspectsoftheteratogenesisofrubellavirus
_version_	1718441598984912896

Molecular aspects of the teratogenesis of rubella virus

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