MicroRNA-107 is a novel tumor suppressor targeting POU3F2 in melanoma

Abstract Background: Melanoma is one of the major types of skin cancer. The metastatic melanoma is among the most lethal forms of malignant skin tumors. We hereby aimed to characterize a novel microRNA (miR) in the metastatic melanoma model. Methods: First, we evaluated the expression of miR-107 i...

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Autores principales:	Zhao,Guizhi, Wei,Zhili, Guo,Yang
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2020
Materias:	Melanoma miR-107 POU3F2 SH-4 Metastasis
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602020000100209
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spelling	oai:scielo:S0716-976020200001002092020-06-25MicroRNA-107 is a novel tumor suppressor targeting POU3F2 in melanomaZhao,GuizhiWei,ZhiliGuo,Yang Melanoma miR-107 POU3F2 SH-4 Metastasis Abstract Background: Melanoma is one of the major types of skin cancer. The metastatic melanoma is among the most lethal forms of malignant skin tumors. We hereby aimed to characterize a novel microRNA (miR) in the metastatic melanoma model. Methods: First, we evaluated the expression of miR-107 in melanoma cells and tumor tissues. The comparison between primary and metastatic cancer tissues was also accessed. Next, we examined the impact of miR-107 on melanoma cell proliferation, cell cycle, colony formation, apoptotic activity, migration and matrix invasion. A downstream target of miR-107 was also predicted and validated functionally in melanoma cells. Results: Our findings showed miR-107 was significantly downregulated in melanoma. Its expression was lowest in metastatic form. Over-expression of miR-107 reduced melanoma cell proliferation, migration and invasion. POU3F2 was identified as the downstream target of miR-107. Over-expression of POU3F2 antagonized miR-107-mediated inhibitory effect on melanoma cells. Conclusion: Our study has reported miR-107 as a novel tumor suppressive factor in the metastatic melanoma model. It has provided new avenue to manage melanoma and improve the survival rate in the advanced stage.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.53 20202020-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602020000100209en10.1186/s40659-020-00278-3
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Melanoma miR-107 POU3F2 SH-4 Metastasis
spellingShingle	Melanoma miR-107 POU3F2 SH-4 Metastasis Zhao,Guizhi Wei,Zhili Guo,Yang MicroRNA-107 is a novel tumor suppressor targeting POU3F2 in melanoma
description	Abstract Background: Melanoma is one of the major types of skin cancer. The metastatic melanoma is among the most lethal forms of malignant skin tumors. We hereby aimed to characterize a novel microRNA (miR) in the metastatic melanoma model. Methods: First, we evaluated the expression of miR-107 in melanoma cells and tumor tissues. The comparison between primary and metastatic cancer tissues was also accessed. Next, we examined the impact of miR-107 on melanoma cell proliferation, cell cycle, colony formation, apoptotic activity, migration and matrix invasion. A downstream target of miR-107 was also predicted and validated functionally in melanoma cells. Results: Our findings showed miR-107 was significantly downregulated in melanoma. Its expression was lowest in metastatic form. Over-expression of miR-107 reduced melanoma cell proliferation, migration and invasion. POU3F2 was identified as the downstream target of miR-107. Over-expression of POU3F2 antagonized miR-107-mediated inhibitory effect on melanoma cells. Conclusion: Our study has reported miR-107 as a novel tumor suppressive factor in the metastatic melanoma model. It has provided new avenue to manage melanoma and improve the survival rate in the advanced stage.
author	Zhao,Guizhi Wei,Zhili Guo,Yang
author_facet	Zhao,Guizhi Wei,Zhili Guo,Yang
author_sort	Zhao,Guizhi
title	MicroRNA-107 is a novel tumor suppressor targeting POU3F2 in melanoma
title_short	MicroRNA-107 is a novel tumor suppressor targeting POU3F2 in melanoma
title_full	MicroRNA-107 is a novel tumor suppressor targeting POU3F2 in melanoma
title_fullStr	MicroRNA-107 is a novel tumor suppressor targeting POU3F2 in melanoma
title_full_unstemmed	MicroRNA-107 is a novel tumor suppressor targeting POU3F2 in melanoma
title_sort	microrna-107 is a novel tumor suppressor targeting pou3f2 in melanoma
publisher	Sociedad de Biología de Chile
publishDate	2020
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602020000100209
work_keys_str_mv	AT zhaoguizhi microrna107isanoveltumorsuppressortargetingpou3f2inmelanoma AT weizhili microrna107isanoveltumorsuppressortargetingpou3f2inmelanoma AT guoyang microrna107isanoveltumorsuppressortargetingpou3f2inmelanoma
_version_	1718441601532952576

MicroRNA-107 is a novel tumor suppressor targeting POU3F2 in melanoma

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