Knockdown of long non-coding RNA HOTAIR reverses cisplatin resistance of ovarian cancer cells through inhibiting miR-138-5p-regulated EZH2 and SIRT1

Knockdown of long non-coding RNA HOTAIR reverses cisplatin resistance of ovarian cancer cells through inhibiting miR-138-5p-regulated EZH2 and SIRT1

Abstract Background: Cisplatin resistance (DDP-resistance) remains one of the major causes of poor prognosis in females with ovarian cancer. Long non-coding RNAs (lncRNAs) have been shown to participate in the regulation of cellular processes, including chemoresistance. The aim of this study was to...

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Autores principales: Zhang,Yun, Ai,Hao, Fan,Xue, Chen,Suxian, Wang,Yadi, Liu,Lili
Lenguaje:English
Publicado: Sociedad de Biología de Chile 2020
Materias:
Ovarian cancer
DDP resistance
HOTAIR
miR-138-5p
Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602020000100215
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