Analysis of the role of the interleukins in colon cancer

Abstract Background: The role of interleukin family in colon cancer remained controversial. The purpose of this study was to investigate the association between interleukin family and colon cancer progression through bioinformatics methods and to validate such association in clinical patients. Met...

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Autores principales:	Wei,Xiyi, Zhang,Yuan, Yang,Zhou, Sha,Yeqin, Pan,Yitong, Chen,Yusheng, Cai,Lei
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2020
Materias:	Colon cancer Interleukins Tumor progression
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602020000100216
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spelling	oai:scielo:S0716-976020200001002162020-06-25Analysis of the role of the interleukins in colon cancerWei,XiyiZhang,YuanYang,ZhouSha,YeqinPan,YitongChen,YushengCai,Lei Colon cancer Interleukins Tumor progression Abstract Background: The role of interleukin family in colon cancer remained controversial. The purpose of this study was to investigate the association between interleukin family and colon cancer progression through bioinformatics methods and to validate such association in clinical patients. Methods: A total of 15 differentially expressed interleukins between the colon cancer tissue and normal colon tissue were evaluated from the Cancer Genome Atlas (TCGA) database with R software and only interleukin-7 (IL-7) was significantly associated with survival. The signaling pathway associated with IL-7 was then investigated using gene enrichment analysis. In addition, subsets of TNM were analyzed in detail and univariate and multivariate COX regression analysis were conducted. Finally, we performed western blotting, immunohistochemistry, cell proliferation and cell apoptosis analysis to examine the expression of IL-7 in patients with intestinal cancer. Results: The study demonstrated that IL-7 could inhibit the progression of colon cancer. In addition, IL-7 was found to be associated with overall survival (OS) and pathological stage. Further analysis of IL-7 expression with clinical data indicated that IL-7 was a key factor in inhibiting colon cancer progression. Conclusion: IL-7 was a key factor in inhibiting the progression of colon cancer and was closely related to overall survival.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.53 20202020-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602020000100216en10.1186/s40659-020-00287-2
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Colon cancer Interleukins Tumor progression
spellingShingle	Colon cancer Interleukins Tumor progression Wei,Xiyi Zhang,Yuan Yang,Zhou Sha,Yeqin Pan,Yitong Chen,Yusheng Cai,Lei Analysis of the role of the interleukins in colon cancer
description	Abstract Background: The role of interleukin family in colon cancer remained controversial. The purpose of this study was to investigate the association between interleukin family and colon cancer progression through bioinformatics methods and to validate such association in clinical patients. Methods: A total of 15 differentially expressed interleukins between the colon cancer tissue and normal colon tissue were evaluated from the Cancer Genome Atlas (TCGA) database with R software and only interleukin-7 (IL-7) was significantly associated with survival. The signaling pathway associated with IL-7 was then investigated using gene enrichment analysis. In addition, subsets of TNM were analyzed in detail and univariate and multivariate COX regression analysis were conducted. Finally, we performed western blotting, immunohistochemistry, cell proliferation and cell apoptosis analysis to examine the expression of IL-7 in patients with intestinal cancer. Results: The study demonstrated that IL-7 could inhibit the progression of colon cancer. In addition, IL-7 was found to be associated with overall survival (OS) and pathological stage. Further analysis of IL-7 expression with clinical data indicated that IL-7 was a key factor in inhibiting colon cancer progression. Conclusion: IL-7 was a key factor in inhibiting the progression of colon cancer and was closely related to overall survival.
author	Wei,Xiyi Zhang,Yuan Yang,Zhou Sha,Yeqin Pan,Yitong Chen,Yusheng Cai,Lei
author_facet	Wei,Xiyi Zhang,Yuan Yang,Zhou Sha,Yeqin Pan,Yitong Chen,Yusheng Cai,Lei
author_sort	Wei,Xiyi
title	Analysis of the role of the interleukins in colon cancer
title_short	Analysis of the role of the interleukins in colon cancer
title_full	Analysis of the role of the interleukins in colon cancer
title_fullStr	Analysis of the role of the interleukins in colon cancer
title_full_unstemmed	Analysis of the role of the interleukins in colon cancer
title_sort	analysis of the role of the interleukins in colon cancer
publisher	Sociedad de Biología de Chile
publishDate	2020
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602020000100216
work_keys_str_mv	AT weixiyi analysisoftheroleoftheinterleukinsincoloncancer AT zhangyuan analysisoftheroleoftheinterleukinsincoloncancer AT yangzhou analysisoftheroleoftheinterleukinsincoloncancer AT shayeqin analysisoftheroleoftheinterleukinsincoloncancer AT panyitong analysisoftheroleoftheinterleukinsincoloncancer AT chenyusheng analysisoftheroleoftheinterleukinsincoloncancer AT cailei analysisoftheroleoftheinterleukinsincoloncancer
_version_	1718441603698262016

Analysis of the role of the interleukins in colon cancer

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