Altered thalamic neurotransmitters metabolism and functional connectivity during the development of chronic constriction injury induced neuropathic pain

Abstract Background: To investigate the thalamic neurotransmitters and functional connections in the development of chronic constriction injury (CCI)-induced neuropathic pain. Methods: The paw withdrawal threshold was measured by mechanical stimulation the right hind paw with the von frey hair in...

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Autores principales:	Wang,Zhifu, Huang,Sheng, Yu,Xiangmei, Li,Long, Yang,Minguang, Liang,Shengxiang, Liu,Weilin, Tao,Jing
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2020
Materias:	Chronic pain N-acetylaspartate (NAA) Glutamate (Glu) Central sensitization Thalamic functional connectivity
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602020000100228
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spelling	oai:scielo:S0716-976020200001002282020-09-27Altered thalamic neurotransmitters metabolism and functional connectivity during the development of chronic constriction injury induced neuropathic painWang,ZhifuHuang,ShengYu,XiangmeiLi,LongYang,MinguangLiang,ShengxiangLiu,WeilinTao,Jing Chronic pain N-acetylaspartate (NAA) Glutamate (Glu) Central sensitization Thalamic functional connectivity Abstract Background: To investigate the thalamic neurotransmitters and functional connections in the development of chronic constriction injury (CCI)-induced neuropathic pain. Methods: The paw withdrawal threshold was measured by mechanical stimulation the right hind paw with the von frey hair in the rats of CCI-induced neuropathic pain. The N-acetylaspartate (NAA) and Glutamate (Glu) in thalamus were detected by magnetic resonance spectrum (MRS) process. The thalamic functional connectivity with other brain regions was scanned by functional magnetic resonance image (fMRI). Results: The paw withdrawal threshold of the ipsilateral side showed a noticeable decline during the pathological process. Increased concentrations of Glu and decreased levels of NAA in the thalamus were significantly correlated with mechanical allodynia in the neuropathic pain states. The thalamic regional homogeneity (ReHo) decreased during the process of neuropathic pain. The functional connectivity among the thalamus with the insula and somatosensory cortex were significantly increased at different time points (7, 14, 21 days) after CCI surgery. Conclusion: Our study suggests that dynamic changes in thalamic NAA and Glu levels contribute to the thalamic functional connection hyper-excitation during CCI-induced neuropathic pain. Enhanced thalamus-insula functional connection might have a significant effect on the occurrence of neuropathic pain.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.53 20202020-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602020000100228en10.1186/s40659-020-00303-5
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Chronic pain N-acetylaspartate (NAA) Glutamate (Glu) Central sensitization Thalamic functional connectivity
spellingShingle	Chronic pain N-acetylaspartate (NAA) Glutamate (Glu) Central sensitization Thalamic functional connectivity Wang,Zhifu Huang,Sheng Yu,Xiangmei Li,Long Yang,Minguang Liang,Shengxiang Liu,Weilin Tao,Jing Altered thalamic neurotransmitters metabolism and functional connectivity during the development of chronic constriction injury induced neuropathic pain
description	Abstract Background: To investigate the thalamic neurotransmitters and functional connections in the development of chronic constriction injury (CCI)-induced neuropathic pain. Methods: The paw withdrawal threshold was measured by mechanical stimulation the right hind paw with the von frey hair in the rats of CCI-induced neuropathic pain. The N-acetylaspartate (NAA) and Glutamate (Glu) in thalamus were detected by magnetic resonance spectrum (MRS) process. The thalamic functional connectivity with other brain regions was scanned by functional magnetic resonance image (fMRI). Results: The paw withdrawal threshold of the ipsilateral side showed a noticeable decline during the pathological process. Increased concentrations of Glu and decreased levels of NAA in the thalamus were significantly correlated with mechanical allodynia in the neuropathic pain states. The thalamic regional homogeneity (ReHo) decreased during the process of neuropathic pain. The functional connectivity among the thalamus with the insula and somatosensory cortex were significantly increased at different time points (7, 14, 21 days) after CCI surgery. Conclusion: Our study suggests that dynamic changes in thalamic NAA and Glu levels contribute to the thalamic functional connection hyper-excitation during CCI-induced neuropathic pain. Enhanced thalamus-insula functional connection might have a significant effect on the occurrence of neuropathic pain.
author	Wang,Zhifu Huang,Sheng Yu,Xiangmei Li,Long Yang,Minguang Liang,Shengxiang Liu,Weilin Tao,Jing
author_facet	Wang,Zhifu Huang,Sheng Yu,Xiangmei Li,Long Yang,Minguang Liang,Shengxiang Liu,Weilin Tao,Jing
author_sort	Wang,Zhifu
title	Altered thalamic neurotransmitters metabolism and functional connectivity during the development of chronic constriction injury induced neuropathic pain
title_short	Altered thalamic neurotransmitters metabolism and functional connectivity during the development of chronic constriction injury induced neuropathic pain
title_full	Altered thalamic neurotransmitters metabolism and functional connectivity during the development of chronic constriction injury induced neuropathic pain
title_fullStr	Altered thalamic neurotransmitters metabolism and functional connectivity during the development of chronic constriction injury induced neuropathic pain
title_full_unstemmed	Altered thalamic neurotransmitters metabolism and functional connectivity during the development of chronic constriction injury induced neuropathic pain
title_sort	altered thalamic neurotransmitters metabolism and functional connectivity during the development of chronic constriction injury induced neuropathic pain
publisher	Sociedad de Biología de Chile
publishDate	2020
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602020000100228
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Altered thalamic neurotransmitters metabolism and functional connectivity during the development of chronic constriction injury induced neuropathic pain

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