REC8 suppresses tumor angiogenesis by inhibition of NF-κB-mediated vascular endothelial growth factor expression in gastric cancer cells
Abstract Background: Tumor angiogenesis is an essential event for tumor growth and metastasis. It has been showed that REC8, a component of the meiotic cohesion complex, played a vital role in Epithelial-Mesenchymal Transition (EMT) in gastric cancer. However, the role of REC8 in gastric cancer ang...
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Sociedad de Biología de Chile
2020
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oai:scielo:S0716-976020200001002312020-10-20REC8 suppresses tumor angiogenesis by inhibition of NF-κB-mediated vascular endothelial growth factor expression in gastric cancer cellsLiu,MiaoXu,WanfuSu,MingminFan,Pingsheng REC8 Tumor angiogenesis VEGF Gastric cancer Abstract Background: Tumor angiogenesis is an essential event for tumor growth and metastasis. It has been showed that REC8, a component of the meiotic cohesion complex, played a vital role in Epithelial-Mesenchymal Transition (EMT) in gastric cancer. However, the role of REC8 in gastric cancer angiogenesis remains to be identified. Results: Inhibition of REC8 expression in gastric cancer cells contributed to tumor angiogenesis in the gastric cancer microenvironment. The clinical analysis demonstrated that the loss of REC8 in gastric cancer with enrichment of MVD. Depletion of REC8 expression in gastric cancer cells significantly increased tube formation of human umbilical vein endothelial cells (HUVECs), which is attributed to enhancement of vascular endothelial growth factor (VEGF) secretion caused by REC8 slicing. While addition of neutralizing antibody targeted VEGF into supernatant drastically reversed the effect of REC8 loss in gastric cancer cells on tube formation. Mechanistic analyses indicated that ablation of REC8 promotes nuclear factor-κΒ (NF-κΒ) p65 activity and its downstream gene VEGF expression, leading to tube formation. Conclusions: These results demonstrated a novel REC8 function that suppressed tumor angiogenesis and progression by attenuation of VEGF in gastric cancer microenvironment.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.53 20202020-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602020000100231en10.1186/s40659-020-00307-1 |
| institution |
Scielo Chile |
| collection |
Scielo Chile |
| language |
English |
| topic |
REC8 Tumor angiogenesis VEGF Gastric cancer |
| spellingShingle |
REC8 Tumor angiogenesis VEGF Gastric cancer Liu,Miao Xu,Wanfu Su,Mingmin Fan,Pingsheng REC8 suppresses tumor angiogenesis by inhibition of NF-κB-mediated vascular endothelial growth factor expression in gastric cancer cells |
| description |
Abstract Background: Tumor angiogenesis is an essential event for tumor growth and metastasis. It has been showed that REC8, a component of the meiotic cohesion complex, played a vital role in Epithelial-Mesenchymal Transition (EMT) in gastric cancer. However, the role of REC8 in gastric cancer angiogenesis remains to be identified. Results: Inhibition of REC8 expression in gastric cancer cells contributed to tumor angiogenesis in the gastric cancer microenvironment. The clinical analysis demonstrated that the loss of REC8 in gastric cancer with enrichment of MVD. Depletion of REC8 expression in gastric cancer cells significantly increased tube formation of human umbilical vein endothelial cells (HUVECs), which is attributed to enhancement of vascular endothelial growth factor (VEGF) secretion caused by REC8 slicing. While addition of neutralizing antibody targeted VEGF into supernatant drastically reversed the effect of REC8 loss in gastric cancer cells on tube formation. Mechanistic analyses indicated that ablation of REC8 promotes nuclear factor-κΒ (NF-κΒ) p65 activity and its downstream gene VEGF expression, leading to tube formation. Conclusions: These results demonstrated a novel REC8 function that suppressed tumor angiogenesis and progression by attenuation of VEGF in gastric cancer microenvironment. |
| author |
Liu,Miao Xu,Wanfu Su,Mingmin Fan,Pingsheng |
| author_facet |
Liu,Miao Xu,Wanfu Su,Mingmin Fan,Pingsheng |
| author_sort |
Liu,Miao |
| title |
REC8 suppresses tumor angiogenesis by inhibition of NF-κB-mediated vascular endothelial growth factor expression in gastric cancer cells |
| title_short |
REC8 suppresses tumor angiogenesis by inhibition of NF-κB-mediated vascular endothelial growth factor expression in gastric cancer cells |
| title_full |
REC8 suppresses tumor angiogenesis by inhibition of NF-κB-mediated vascular endothelial growth factor expression in gastric cancer cells |
| title_fullStr |
REC8 suppresses tumor angiogenesis by inhibition of NF-κB-mediated vascular endothelial growth factor expression in gastric cancer cells |
| title_full_unstemmed |
REC8 suppresses tumor angiogenesis by inhibition of NF-κB-mediated vascular endothelial growth factor expression in gastric cancer cells |
| title_sort |
rec8 suppresses tumor angiogenesis by inhibition of nf-κb-mediated vascular endothelial growth factor expression in gastric cancer cells |
| publisher |
Sociedad de Biología de Chile |
| publishDate |
2020 |
| url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602020000100231 |
| work_keys_str_mv |
AT liumiao rec8suppressestumorangiogenesisbyinhibitionofnf954bmediatedvascularendothelialgrowthfactorexpressioningastriccancercells AT xuwanfu rec8suppressestumorangiogenesisbyinhibitionofnf954bmediatedvascularendothelialgrowthfactorexpressioningastriccancercells AT sumingmin rec8suppressestumorangiogenesisbyinhibitionofnf954bmediatedvascularendothelialgrowthfactorexpressioningastriccancercells AT fanpingsheng rec8suppressestumorangiogenesisbyinhibitionofnf954bmediatedvascularendothelialgrowthfactorexpressioningastriccancercells |
| _version_ |
1718441607793999872 |