MiR-128 suppresses metastatic capacity by targeting metadherin in breast cancer cells

Abstract Background: Breast cancer, the most common cancer in women worldwide, causes the vast majority of cancer-related deaths. Undoubtedly, tumor metastasis and recurrence are responsible for more than 90 percent of these deaths. MicroRNAs are endogenous noncoding RNAs that have been integrated...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Cao,Danxia, Zhu,Han, Zhao,Qian, Huang,Jianming, Zhou,Cixiang, He,Jianrong, Liang,Yongjun
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2020
Materias:	miR-128 Breast cancer Metastasis MTDH
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602020000100233
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:scielo:S0716-97602020000100233
record_format	dspace
spelling	oai:scielo:S0716-976020200001002332020-10-20MiR-128 suppresses metastatic capacity by targeting metadherin in breast cancer cellsCao,DanxiaZhu,HanZhao,QianHuang,JianmingZhou,CixiangHe,JianrongLiang,Yongjun miR-128 Breast cancer Metastasis MTDH Abstract Background: Breast cancer, the most common cancer in women worldwide, causes the vast majority of cancer-related deaths. Undoubtedly, tumor metastasis and recurrence are responsible for more than 90 percent of these deaths. MicroRNAs are endogenous noncoding RNAs that have been integrated into almost all the physiological and pathological processes, including metastasis. In the present study, the role of miR-128 in breast cancer was investigated. Results: Compared to the corresponding adjacent normal tissue, the expression of miR-128 was significantly suppressed in human breast cancer specimens. More importantly, its expression level was reversely correlated to histological grade of the cancer. Ectopic expression of miR-128 in the aggressive breast cancer cell line MDA-MB-231 could inhibit cell motility and invasive capacity remarkably. Afterwards, Metadherin (MTDH), also known as AEG-1 (Astrocyte Elevated Gene 1) and Lyric that implicated in various aspects of cancer progression and metastasis, was further identified as a direct target gene of miR-128 and its expression level was up-regulated in clinical samples as expected. Moreover, knockdown of MTDH in MDA-MB-231 cells obviously impaired the migration and invasion capabilities, whereas re-expression of MTDH abrogated the suppressive effect caused by miR-128. Conclusions: Overall, these findings demonstrate that miR-128 could serve as a novel biomarker for breast cancer metastasis and a potent target for treatment in the future.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.53 20202020-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602020000100233en10.1186/s40659-020-00311-5
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	miR-128 Breast cancer Metastasis MTDH
spellingShingle	miR-128 Breast cancer Metastasis MTDH Cao,Danxia Zhu,Han Zhao,Qian Huang,Jianming Zhou,Cixiang He,Jianrong Liang,Yongjun MiR-128 suppresses metastatic capacity by targeting metadherin in breast cancer cells
description	Abstract Background: Breast cancer, the most common cancer in women worldwide, causes the vast majority of cancer-related deaths. Undoubtedly, tumor metastasis and recurrence are responsible for more than 90 percent of these deaths. MicroRNAs are endogenous noncoding RNAs that have been integrated into almost all the physiological and pathological processes, including metastasis. In the present study, the role of miR-128 in breast cancer was investigated. Results: Compared to the corresponding adjacent normal tissue, the expression of miR-128 was significantly suppressed in human breast cancer specimens. More importantly, its expression level was reversely correlated to histological grade of the cancer. Ectopic expression of miR-128 in the aggressive breast cancer cell line MDA-MB-231 could inhibit cell motility and invasive capacity remarkably. Afterwards, Metadherin (MTDH), also known as AEG-1 (Astrocyte Elevated Gene 1) and Lyric that implicated in various aspects of cancer progression and metastasis, was further identified as a direct target gene of miR-128 and its expression level was up-regulated in clinical samples as expected. Moreover, knockdown of MTDH in MDA-MB-231 cells obviously impaired the migration and invasion capabilities, whereas re-expression of MTDH abrogated the suppressive effect caused by miR-128. Conclusions: Overall, these findings demonstrate that miR-128 could serve as a novel biomarker for breast cancer metastasis and a potent target for treatment in the future.
author	Cao,Danxia Zhu,Han Zhao,Qian Huang,Jianming Zhou,Cixiang He,Jianrong Liang,Yongjun
author_facet	Cao,Danxia Zhu,Han Zhao,Qian Huang,Jianming Zhou,Cixiang He,Jianrong Liang,Yongjun
author_sort	Cao,Danxia
title	MiR-128 suppresses metastatic capacity by targeting metadherin in breast cancer cells
title_short	MiR-128 suppresses metastatic capacity by targeting metadherin in breast cancer cells
title_full	MiR-128 suppresses metastatic capacity by targeting metadherin in breast cancer cells
title_fullStr	MiR-128 suppresses metastatic capacity by targeting metadherin in breast cancer cells
title_full_unstemmed	MiR-128 suppresses metastatic capacity by targeting metadherin in breast cancer cells
title_sort	mir-128 suppresses metastatic capacity by targeting metadherin in breast cancer cells
publisher	Sociedad de Biología de Chile
publishDate	2020
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602020000100233
work_keys_str_mv	AT caodanxia mir128suppressesmetastaticcapacitybytargetingmetadherininbreastcancercells AT zhuhan mir128suppressesmetastaticcapacitybytargetingmetadherininbreastcancercells AT zhaoqian mir128suppressesmetastaticcapacitybytargetingmetadherininbreastcancercells AT huangjianming mir128suppressesmetastaticcapacitybytargetingmetadherininbreastcancercells AT zhoucixiang mir128suppressesmetastaticcapacitybytargetingmetadherininbreastcancercells AT hejianrong mir128suppressesmetastaticcapacitybytargetingmetadherininbreastcancercells AT liangyongjun mir128suppressesmetastaticcapacitybytargetingmetadherininbreastcancercells
_version_	1718441608402173952

MiR-128 suppresses metastatic capacity by targeting metadherin in breast cancer cells

Ejemplares similares