Evaluating the clinical significance of SHMT2 and its co-expressed gene in human kidney cancer

Abstract Background: Kidney cancer is one of the most common cancers in the world. It is necessary to clarify its underlying mechanism and find its prognostic biomarkers. Current studies showed that SHMT2 may be participated in several kinds of cancer. Methods: Our studies investigated the express...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Wang,Huan, Chong,Tie, Li,Bo-Yong, Chen,Xiao-San, Zhen,Wen-Bo
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2020
Materias:	SHMT2 NDUFA4L2 Prognosis Kidney cancer Bioinformatic analysis
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602020000100300
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:scielo:S0716-97602020000100300
record_format	dspace
spelling	oai:scielo:S0716-976020200001003002020-10-26Evaluating the clinical significance of SHMT2 and its co-expressed gene in human kidney cancerWang,HuanChong,TieLi,Bo-YongChen,Xiao-SanZhen,Wen-Bo SHMT2 NDUFA4L2 Prognosis Kidney cancer Bioinformatic analysis Abstract Background: Kidney cancer is one of the most common cancers in the world. It is necessary to clarify its underlying mechanism and find its prognostic biomarkers. Current studies showed that SHMT2 may be participated in several kinds of cancer. Methods: Our studies investigated the expression of SHMT2 in kidney cancer by Oncomine, Human Protein Atlas database and ULCAN database. Meanwhile, we found its co-expression gene by cBioPortal online tool and validated their relationship in A498 and ACHN cells by cell transfection, western blot and qRT-PCR. Besides these, we also explored their prognostic values via the Kaplan-Meier plotter database in different types of kidney cancer patients. Results: SHMT2 was found to be increased in 7 kidney cancer datasets, compared to normal renal tissues. For the cancer stages, ages and races, there existed significant difference in the expression of SHMT2 among different groups by mining of the UALCAN database. High SHMT2 expression is associated with poor overall survival in patients with kidney cancer. Among all co-expressed genes, NDUFA4L2 and SHMT2 had a high co-expression efficient. SHMT2 overexpression led to the increased expression of NDUFA4L2 at both mRNA and protein levels. Like SHMT2, overexpressed NDUFA4L2 also was associated with worse overall survival in patients with kidney cancer. Conclusion: Based on above results, overexpressed SHMT2 and its co-expressed gene NDUFA4L2 were all correlated with the prognosis in kidney cancer. The present study might be benefit for better understanding the clinical significance of SHMT2 and provided a potential therapeutic target for kidney cancer in future.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.53 20202020-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602020000100300en10.1186/s40659-020-00314-2
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	SHMT2 NDUFA4L2 Prognosis Kidney cancer Bioinformatic analysis
spellingShingle	SHMT2 NDUFA4L2 Prognosis Kidney cancer Bioinformatic analysis Wang,Huan Chong,Tie Li,Bo-Yong Chen,Xiao-San Zhen,Wen-Bo Evaluating the clinical significance of SHMT2 and its co-expressed gene in human kidney cancer
description	Abstract Background: Kidney cancer is one of the most common cancers in the world. It is necessary to clarify its underlying mechanism and find its prognostic biomarkers. Current studies showed that SHMT2 may be participated in several kinds of cancer. Methods: Our studies investigated the expression of SHMT2 in kidney cancer by Oncomine, Human Protein Atlas database and ULCAN database. Meanwhile, we found its co-expression gene by cBioPortal online tool and validated their relationship in A498 and ACHN cells by cell transfection, western blot and qRT-PCR. Besides these, we also explored their prognostic values via the Kaplan-Meier plotter database in different types of kidney cancer patients. Results: SHMT2 was found to be increased in 7 kidney cancer datasets, compared to normal renal tissues. For the cancer stages, ages and races, there existed significant difference in the expression of SHMT2 among different groups by mining of the UALCAN database. High SHMT2 expression is associated with poor overall survival in patients with kidney cancer. Among all co-expressed genes, NDUFA4L2 and SHMT2 had a high co-expression efficient. SHMT2 overexpression led to the increased expression of NDUFA4L2 at both mRNA and protein levels. Like SHMT2, overexpressed NDUFA4L2 also was associated with worse overall survival in patients with kidney cancer. Conclusion: Based on above results, overexpressed SHMT2 and its co-expressed gene NDUFA4L2 were all correlated with the prognosis in kidney cancer. The present study might be benefit for better understanding the clinical significance of SHMT2 and provided a potential therapeutic target for kidney cancer in future.
author	Wang,Huan Chong,Tie Li,Bo-Yong Chen,Xiao-San Zhen,Wen-Bo
author_facet	Wang,Huan Chong,Tie Li,Bo-Yong Chen,Xiao-San Zhen,Wen-Bo
author_sort	Wang,Huan
title	Evaluating the clinical significance of SHMT2 and its co-expressed gene in human kidney cancer
title_short	Evaluating the clinical significance of SHMT2 and its co-expressed gene in human kidney cancer
title_full	Evaluating the clinical significance of SHMT2 and its co-expressed gene in human kidney cancer
title_fullStr	Evaluating the clinical significance of SHMT2 and its co-expressed gene in human kidney cancer
title_full_unstemmed	Evaluating the clinical significance of SHMT2 and its co-expressed gene in human kidney cancer
title_sort	evaluating the clinical significance of shmt2 and its co-expressed gene in human kidney cancer
publisher	Sociedad de Biología de Chile
publishDate	2020
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602020000100300
work_keys_str_mv	AT wanghuan evaluatingtheclinicalsignificanceofshmt2anditscoexpressedgeneinhumankidneycancer AT chongtie evaluatingtheclinicalsignificanceofshmt2anditscoexpressedgeneinhumankidneycancer AT liboyong evaluatingtheclinicalsignificanceofshmt2anditscoexpressedgeneinhumankidneycancer AT chenxiaosan evaluatingtheclinicalsignificanceofshmt2anditscoexpressedgeneinhumankidneycancer AT zhenwenbo evaluatingtheclinicalsignificanceofshmt2anditscoexpressedgeneinhumankidneycancer
_version_	1718441611340283904

Evaluating the clinical significance of SHMT2 and its co-expressed gene in human kidney cancer

Ejemplares similares