β-Catenin: oncogenic role and therapeutic target in cervical cancer
Abstract Cervical cancer is a common and fatal malignancy of the female reproductive system. Human papillomavirus (HPV) is the primary causal agent for cervical cancer, but HPV infection alone is insufficient to cause the disease. Actually, most HPV infections are sub-clinical and cleared spontaneou...
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| Lenguaje: | English |
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Sociedad de Biología de Chile
2020
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oai:scielo:S0716-976020200001005032020-08-24β-Catenin: oncogenic role and therapeutic target in cervical cancerWang,BingqiLi,XianpingLiu,LeiWang,Min β-Catenin Cervical cancer Cell-cell adhesion Wnt signaling pathway Abstract Cervical cancer is a common and fatal malignancy of the female reproductive system. Human papillomavirus (HPV) is the primary causal agent for cervical cancer, but HPV infection alone is insufficient to cause the disease. Actually, most HPV infections are sub-clinical and cleared spontaneously by the host immune system; very few persist and eventually develop into cervical cancer. Therefore, other host or environmental alterations could also contribute to the malignant phenotype. One of the candidate co-factors is the β-catenin protein, a pivotal component of the Wnt/β-catenin signaling pathway. β-Catenin mainly implicates two major cellular activities: cell-cell adhesion and signal transduction. Recent studies have indicated that an imbalance in the structural and signaling properties of β-catenin leads to various cancers, such as cervical cancer. In this review, we will systematically summarize the role of β-catenin in cervical cancer and provide new insights into therapeutic strategies.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.53 20202020-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602020000100503en10.1186/s40659-020-00301-7 |
| institution |
Scielo Chile |
| collection |
Scielo Chile |
| language |
English |
| topic |
β-Catenin Cervical cancer Cell-cell adhesion Wnt signaling pathway |
| spellingShingle |
β-Catenin Cervical cancer Cell-cell adhesion Wnt signaling pathway Wang,Bingqi Li,Xianping Liu,Lei Wang,Min β-Catenin: oncogenic role and therapeutic target in cervical cancer |
| description |
Abstract Cervical cancer is a common and fatal malignancy of the female reproductive system. Human papillomavirus (HPV) is the primary causal agent for cervical cancer, but HPV infection alone is insufficient to cause the disease. Actually, most HPV infections are sub-clinical and cleared spontaneously by the host immune system; very few persist and eventually develop into cervical cancer. Therefore, other host or environmental alterations could also contribute to the malignant phenotype. One of the candidate co-factors is the β-catenin protein, a pivotal component of the Wnt/β-catenin signaling pathway. β-Catenin mainly implicates two major cellular activities: cell-cell adhesion and signal transduction. Recent studies have indicated that an imbalance in the structural and signaling properties of β-catenin leads to various cancers, such as cervical cancer. In this review, we will systematically summarize the role of β-catenin in cervical cancer and provide new insights into therapeutic strategies. |
| author |
Wang,Bingqi Li,Xianping Liu,Lei Wang,Min |
| author_facet |
Wang,Bingqi Li,Xianping Liu,Lei Wang,Min |
| author_sort |
Wang,Bingqi |
| title |
β-Catenin: oncogenic role and therapeutic target in cervical cancer |
| title_short |
β-Catenin: oncogenic role and therapeutic target in cervical cancer |
| title_full |
β-Catenin: oncogenic role and therapeutic target in cervical cancer |
| title_fullStr |
β-Catenin: oncogenic role and therapeutic target in cervical cancer |
| title_full_unstemmed |
β-Catenin: oncogenic role and therapeutic target in cervical cancer |
| title_sort |
β-catenin: oncogenic role and therapeutic target in cervical cancer |
| publisher |
Sociedad de Biología de Chile |
| publishDate |
2020 |
| url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602020000100503 |
| work_keys_str_mv |
AT wangbingqi 946cateninoncogenicroleandtherapeutictargetincervicalcancer AT lixianping 946cateninoncogenicroleandtherapeutictargetincervicalcancer AT liulei 946cateninoncogenicroleandtherapeutictargetincervicalcancer AT wangmin 946cateninoncogenicroleandtherapeutictargetincervicalcancer |
| _version_ |
1718441612428705792 |