LncRNA MALAT1 aggravates oxygen‐glucose deprivation/reoxygenation-induced neuronal endoplasmic reticulum stress and apoptosis via the miR-195a-5p/HMGA1 axis

LncRNA MALAT1 aggravates oxygen‐glucose deprivation/reoxygenation-induced neuronal endoplasmic reticulum stress and apoptosis via the miR-195a-5p/HMGA1 axis

Abstract Background: This study aimed to investigate the potential role and molecular mechanism of lncRNA metastasis associated lung adenocarcinoma transcript 1 (MALAT1) in cerebral ischemia/reperfusion injury. Results: Using an oxygen-glucose deprivation/reoxygenation (OGD/R) cell model, we deter...

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Autores principales: Jia,Ying, Yi,Lian, Li,Qianqian, Liu,Tingjiao, Yang,Shanshan
Lenguaje:English
Publicado: Sociedad de Biología de Chile 2021
Materias:
Ischemic stroke
MALAT1
Oxygen‐glucose deprivation/reoxygenation
Neuronal injury
Endoplasmic reticulum stress
Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602021000100208
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spelling oai:scielo:S0716-976020210001002082021-03-29LncRNA MALAT1 aggravates oxygen‐glucose deprivation/reoxygenation-induced neuronal endoplasmic reticulum stress and apoptosis via the miR-195a-5p/HMGA1 axisJia,YingYi,LianLi,QianqianLiu,TingjiaoYang,Shanshan Ischemic stroke MALAT1 Oxygen‐glucose deprivation/reoxygenation Neuronal injury Endoplasmic reticulum stress Abstract Background: This study aimed to investigate the potential role and molecular mechanism of lncRNA metastasis associated lung adenocarcinoma transcript 1 (MALAT1) in cerebral ischemia/reperfusion injury. Results: Using an oxygen-glucose deprivation/reoxygenation (OGD/R) cell model, we determined that the expression of MALAT1 was significantly increased during OGD/R. MALAT1 knockdown reversed OGD/R-induced apoptosis and ER stress. Mechanistically, MALAT1 promoted OGD/R-induced neuronal injury through sponging miR-195a-5p to upregulating high mobility group AT-hook1 (HMGA1). Conclusions: Collectively, these data demonstrate the mechanism underlying the invovlvement of MALAT1 in cerebral ischemia/reperfusion injury, thus providing translational evidence that MALAT1 may serve as a novel biomarker and therapeutic target for ischemic stroke.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.54 20212021-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602021000100208en10.1186/s40659-021-00331-9
institution Scielo Chile
collection Scielo Chile
language English
topic Ischemic stroke
MALAT1
Oxygen‐glucose deprivation/reoxygenation
Neuronal injury
Endoplasmic reticulum stress
spellingShingle Ischemic stroke
MALAT1
Oxygen‐glucose deprivation/reoxygenation
Neuronal injury
Endoplasmic reticulum stress
Jia,Ying
Yi,Lian
Li,Qianqian
Liu,Tingjiao
Yang,Shanshan
LncRNA MALAT1 aggravates oxygen‐glucose deprivation/reoxygenation-induced neuronal endoplasmic reticulum stress and apoptosis via the miR-195a-5p/HMGA1 axis
description Abstract Background: This study aimed to investigate the potential role and molecular mechanism of lncRNA metastasis associated lung adenocarcinoma transcript 1 (MALAT1) in cerebral ischemia/reperfusion injury. Results: Using an oxygen-glucose deprivation/reoxygenation (OGD/R) cell model, we determined that the expression of MALAT1 was significantly increased during OGD/R. MALAT1 knockdown reversed OGD/R-induced apoptosis and ER stress. Mechanistically, MALAT1 promoted OGD/R-induced neuronal injury through sponging miR-195a-5p to upregulating high mobility group AT-hook1 (HMGA1). Conclusions: Collectively, these data demonstrate the mechanism underlying the invovlvement of MALAT1 in cerebral ischemia/reperfusion injury, thus providing translational evidence that MALAT1 may serve as a novel biomarker and therapeutic target for ischemic stroke.
author Jia,Ying
Yi,Lian
Li,Qianqian
Liu,Tingjiao
Yang,Shanshan
author_facet Jia,Ying
Yi,Lian
Li,Qianqian
Liu,Tingjiao
Yang,Shanshan
author_sort Jia,Ying
title LncRNA MALAT1 aggravates oxygen‐glucose deprivation/reoxygenation-induced neuronal endoplasmic reticulum stress and apoptosis via the miR-195a-5p/HMGA1 axis
title_short LncRNA MALAT1 aggravates oxygen‐glucose deprivation/reoxygenation-induced neuronal endoplasmic reticulum stress and apoptosis via the miR-195a-5p/HMGA1 axis
title_full LncRNA MALAT1 aggravates oxygen‐glucose deprivation/reoxygenation-induced neuronal endoplasmic reticulum stress and apoptosis via the miR-195a-5p/HMGA1 axis
title_fullStr LncRNA MALAT1 aggravates oxygen‐glucose deprivation/reoxygenation-induced neuronal endoplasmic reticulum stress and apoptosis via the miR-195a-5p/HMGA1 axis
title_full_unstemmed LncRNA MALAT1 aggravates oxygen‐glucose deprivation/reoxygenation-induced neuronal endoplasmic reticulum stress and apoptosis via the miR-195a-5p/HMGA1 axis
title_sort lncrna malat1 aggravates oxygen‐glucose deprivation/reoxygenation-induced neuronal endoplasmic reticulum stress and apoptosis via the mir-195a-5p/hmga1 axis
publisher Sociedad de Biología de Chile
publishDate 2021
url http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602021000100208
work_keys_str_mv AT jiaying lncrnamalat1aggravatesoxygen8208glucosedeprivationreoxygenationinducedneuronalendoplasmicreticulumstressandapoptosisviathemir195a5phmga1axis
AT yilian lncrnamalat1aggravatesoxygen8208glucosedeprivationreoxygenationinducedneuronalendoplasmicreticulumstressandapoptosisviathemir195a5phmga1axis
AT liqianqian lncrnamalat1aggravatesoxygen8208glucosedeprivationreoxygenationinducedneuronalendoplasmicreticulumstressandapoptosisviathemir195a5phmga1axis
AT liutingjiao lncrnamalat1aggravatesoxygen8208glucosedeprivationreoxygenationinducedneuronalendoplasmicreticulumstressandapoptosisviathemir195a5phmga1axis
AT yangshanshan lncrnamalat1aggravatesoxygen8208glucosedeprivationreoxygenationinducedneuronalendoplasmicreticulumstressandapoptosisviathemir195a5phmga1axis
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