Long non-coding RNA MALAT1 regulates cell proliferation and apoptosis via miR-135b-5p/GPNMB axis in Parkinson's disease cell model

Abstract Backgrounds: Parkinson's disease (PD) is a common age-related neurodegenerative disorder worldwide. This research aimed to investigate the effects and mechanism underlying long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) in PD. Methods: SK-N-SH and...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Lv,Kefeng, Liu,Yuhua, Zheng,Yanbing, Dai,Shaowen, Yin,Peifeng, Miao,Haifeng
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2021
Materias:	MALAT1 miR-135b-5p GPNMB Parkinson's disease Cell proliferation Apoptosis
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602021000100210
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:scielo:S0716-97602021000100210
record_format	dspace
spelling	oai:scielo:S0716-976020210001002102021-04-28Long non-coding RNA MALAT1 regulates cell proliferation and apoptosis via miR-135b-5p/GPNMB axis in Parkinson's disease cell modelLv,KefengLiu,YuhuaZheng,YanbingDai,ShaowenYin,PeifengMiao,Haifeng MALAT1 miR-135b-5p GPNMB Parkinson's disease Cell proliferation Apoptosis Abstract Backgrounds: Parkinson's disease (PD) is a common age-related neurodegenerative disorder worldwide. This research aimed to investigate the effects and mechanism underlying long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) in PD. Methods: SK-N-SH and SK-N-BE cells were treated with MPP+ to establish the MPP+-stimulated cell model of PD, and MALAT1 expression was determined. Then, the effects of MALAT1 depletion on cell proliferation and apoptosis were determined in the MPP+-stimulated cell model of PD. Besides, the correlations between microRNA-135b-5p (miR-135b-5p) and MALAT1 or glycoprotein nonmetastatic melanoma protein B (GPNMB) in MPP+-stimulated cell model of PD were explored. Results: MALAT1 was increasingly expressed and downregulation of MALAT1 promoted cell proliferation while inhibited apoptosis in MPP+-stimulated cells. Besides, miR-135b-5p was a target of MALAT1 and directly targeted to GPNMB. Further investigation indicated that suppression of MALAT1 regulated cell proliferation and apoptosis by miR-135b-5p/GPNMB axis. Conclusion: Our findings reveal that MALAT1/miR-135b-5p/GPNMB axis regulated cell proliferation and apoptosis in MPP+-stimulated cell model of PD, providing a potential biomarker and therapeutic target for PD.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.54 20212021-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602021000100210en10.1186/s40659-021-00332-8
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	MALAT1 miR-135b-5p GPNMB Parkinson's disease Cell proliferation Apoptosis
spellingShingle	MALAT1 miR-135b-5p GPNMB Parkinson's disease Cell proliferation Apoptosis Lv,Kefeng Liu,Yuhua Zheng,Yanbing Dai,Shaowen Yin,Peifeng Miao,Haifeng Long non-coding RNA MALAT1 regulates cell proliferation and apoptosis via miR-135b-5p/GPNMB axis in Parkinson's disease cell model
description	Abstract Backgrounds: Parkinson's disease (PD) is a common age-related neurodegenerative disorder worldwide. This research aimed to investigate the effects and mechanism underlying long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) in PD. Methods: SK-N-SH and SK-N-BE cells were treated with MPP+ to establish the MPP+-stimulated cell model of PD, and MALAT1 expression was determined. Then, the effects of MALAT1 depletion on cell proliferation and apoptosis were determined in the MPP+-stimulated cell model of PD. Besides, the correlations between microRNA-135b-5p (miR-135b-5p) and MALAT1 or glycoprotein nonmetastatic melanoma protein B (GPNMB) in MPP+-stimulated cell model of PD were explored. Results: MALAT1 was increasingly expressed and downregulation of MALAT1 promoted cell proliferation while inhibited apoptosis in MPP+-stimulated cells. Besides, miR-135b-5p was a target of MALAT1 and directly targeted to GPNMB. Further investigation indicated that suppression of MALAT1 regulated cell proliferation and apoptosis by miR-135b-5p/GPNMB axis. Conclusion: Our findings reveal that MALAT1/miR-135b-5p/GPNMB axis regulated cell proliferation and apoptosis in MPP+-stimulated cell model of PD, providing a potential biomarker and therapeutic target for PD.
author	Lv,Kefeng Liu,Yuhua Zheng,Yanbing Dai,Shaowen Yin,Peifeng Miao,Haifeng
author_facet	Lv,Kefeng Liu,Yuhua Zheng,Yanbing Dai,Shaowen Yin,Peifeng Miao,Haifeng
author_sort	Lv,Kefeng
title	Long non-coding RNA MALAT1 regulates cell proliferation and apoptosis via miR-135b-5p/GPNMB axis in Parkinson's disease cell model
title_short	Long non-coding RNA MALAT1 regulates cell proliferation and apoptosis via miR-135b-5p/GPNMB axis in Parkinson's disease cell model
title_full	Long non-coding RNA MALAT1 regulates cell proliferation and apoptosis via miR-135b-5p/GPNMB axis in Parkinson's disease cell model
title_fullStr	Long non-coding RNA MALAT1 regulates cell proliferation and apoptosis via miR-135b-5p/GPNMB axis in Parkinson's disease cell model
title_full_unstemmed	Long non-coding RNA MALAT1 regulates cell proliferation and apoptosis via miR-135b-5p/GPNMB axis in Parkinson's disease cell model
title_sort	long non-coding rna malat1 regulates cell proliferation and apoptosis via mir-135b-5p/gpnmb axis in parkinson's disease cell model
publisher	Sociedad de Biología de Chile
publishDate	2021
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602021000100210
work_keys_str_mv	AT lvkefeng longnoncodingrnamalat1regulatescellproliferationandapoptosisviamir135b5pgpnmbaxisinparkinsonsdiseasecellmodel AT liuyuhua longnoncodingrnamalat1regulatescellproliferationandapoptosisviamir135b5pgpnmbaxisinparkinsonsdiseasecellmodel AT zhengyanbing longnoncodingrnamalat1regulatescellproliferationandapoptosisviamir135b5pgpnmbaxisinparkinsonsdiseasecellmodel AT daishaowen longnoncodingrnamalat1regulatescellproliferationandapoptosisviamir135b5pgpnmbaxisinparkinsonsdiseasecellmodel AT yinpeifeng longnoncodingrnamalat1regulatescellproliferationandapoptosisviamir135b5pgpnmbaxisinparkinsonsdiseasecellmodel AT miaohaifeng longnoncodingrnamalat1regulatescellproliferationandapoptosisviamir135b5pgpnmbaxisinparkinsonsdiseasecellmodel
_version_	1718441615444410368

Long non-coding RNA MALAT1 regulates cell proliferation and apoptosis via miR-135b-5p/GPNMB axis in Parkinson's disease cell model

Ejemplares similares