NOD1 rs2075820 (p.E266K) polymorphism is associated with gastric cancer among individuals infected with cagPAI–positive H. pylori

NOD1 rs2075820 (p.E266K) polymorphism is associated with gastric cancer among individuals infected with cagPAI–positive H. pylori

Abstract Background: Helicobacter pylori is detected by pathogen recognition receptors including toll–like receptors (TLR) and nucleotide–binding oligomerization domain (NOD)–like receptors, eliciting an innate immune response against this bacteria. The aim of this stu...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Gonzalez–Hormazabal,Patricio, Pelaez,Diana, Musleh,Maher, Bustamante,Marco, Stambuk,Juan, Pisano,Raul, Valladares,Hector, Lanzarini,Enrique, Chiong,Hector, Suazo,Jose, Quiñones,Luis A., Varela,Nelson M., Castro,V. Gonzalo, Jara,Lilian, Berger,Zoltan
Lenguaje:English
Publicado: Sociedad de Biología de Chile 2021
Materias:
Gastric cancer
Polymorphism
Association study
H. pylori
NOD1
E266K
Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602021000100213
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:scielo:S0716-97602021000100213
record_format dspace
spelling oai:scielo:S0716-976020210001002132021-05-14NOD1 rs2075820 (p.E266K) polymorphism is associated with gastric cancer among individuals infected with cagPAI–positive H. pyloriGonzalez–Hormazabal,PatricioPelaez,DianaMusleh,MaherBustamante,MarcoStambuk,JuanPisano,RaulValladares,HectorLanzarini,EnriqueChiong,HectorSuazo,JoseQuiñones,Luis A.Varela,Nelson M.Castro,V. GonzaloJara,LilianBerger,Zoltan Gastric cancer Polymorphism Association study H. pylori NOD1 E266K Abstract Background: Helicobacter pylori is detected by pathogen recognition receptors including toll–like receptors (TLR) and nucleotide–binding oligomerization domain (NOD)–like receptors, eliciting an innate immune response against this bacteria. The aim of this study was to assess if polymorphisms of TLR2, TLR4, TLR5, NOD1 and NOD2 genes are associated with gastric cancer, in particular in individuals infected with H. pylori. Results: A case–control study of 297 gastric cancer patients and 300 controls was performed to assess the association of 17 polymorphisms. Analyses performed under the allele model did not find association with gastric cancer. However, NOD1 rs2075820 (p.E266K) showed association with intestinal–type gastric cancer among H. pylori infected subjects (OR = 2.69, 95% CI 1.41–5.13, p = 0.0026). The association was not statistically significant in diffuse–type gastric cancer cases (OR = 1.26, 95% CI 0.63–2.52, p = 0.51). When the analyses were performed in patients carrying H. pylori strains harboring the cag pathogenicity island (cagPAI), we noticed significant association with NOD1 rs2075820 (OR = 4.90, 95% CI 1.80–3.36, p = 0.0019), in particular for intestinal–type gastric cancer cases (OR = 7.16, 95% CI 2.40–21.33, p = 4.1 × 10−4) but not among diffuse–type gastric cancer cases (OR = 3.39, 95% CI 1.13–0.10, p = 0.03). Conclusions: NOD1 rs2075820 increases the risk of intestinal–type gastric cancer among individuals infected with H. pylori, particularly in those harboring the cagPAI.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.54 20212021-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602021000100213en10.1186/s40659-021-00336-4
institution Scielo Chile
collection Scielo Chile
language English
topic Gastric cancer
Polymorphism
Association study
H. pylori
NOD1
E266K
spellingShingle Gastric cancer
Polymorphism
Association study
H. pylori
NOD1
E266K
Gonzalez–Hormazabal,Patricio
Pelaez,Diana
Musleh,Maher
Bustamante,Marco
Stambuk,Juan
Pisano,Raul
Valladares,Hector
Lanzarini,Enrique
Chiong,Hector
Suazo,Jose
Quiñones,Luis A.
Varela,Nelson M.
Castro,V. Gonzalo
Jara,Lilian
Berger,Zoltan
NOD1 rs2075820 (p.E266K) polymorphism is associated with gastric cancer among individuals infected with cagPAI–positive H. pylori
description Abstract Background: Helicobacter pylori is detected by pathogen recognition receptors including toll–like receptors (TLR) and nucleotide–binding oligomerization domain (NOD)–like receptors, eliciting an innate immune response against this bacteria. The aim of this study was to assess if polymorphisms of TLR2, TLR4, TLR5, NOD1 and NOD2 genes are associated with gastric cancer, in particular in individuals infected with H. pylori. Results: A case–control study of 297 gastric cancer patients and 300 controls was performed to assess the association of 17 polymorphisms. Analyses performed under the allele model did not find association with gastric cancer. However, NOD1 rs2075820 (p.E266K) showed association with intestinal–type gastric cancer among H. pylori infected subjects (OR = 2.69, 95% CI 1.41–5.13, p = 0.0026). The association was not statistically significant in diffuse–type gastric cancer cases (OR = 1.26, 95% CI 0.63–2.52, p = 0.51). When the analyses were performed in patients carrying H. pylori strains harboring the cag pathogenicity island (cagPAI), we noticed significant association with NOD1 rs2075820 (OR = 4.90, 95% CI 1.80–3.36, p = 0.0019), in particular for intestinal–type gastric cancer cases (OR = 7.16, 95% CI 2.40–21.33, p = 4.1 × 10−4) but not among diffuse–type gastric cancer cases (OR = 3.39, 95% CI 1.13–0.10, p = 0.03). Conclusions: NOD1 rs2075820 increases the risk of intestinal–type gastric cancer among individuals infected with H. pylori, particularly in those harboring the cagPAI.
author Gonzalez–Hormazabal,Patricio
Pelaez,Diana
Musleh,Maher
Bustamante,Marco
Stambuk,Juan
Pisano,Raul
Valladares,Hector
Lanzarini,Enrique
Chiong,Hector
Suazo,Jose
Quiñones,Luis A.
Varela,Nelson M.
Castro,V. Gonzalo
Jara,Lilian
Berger,Zoltan
author_facet Gonzalez–Hormazabal,Patricio
Pelaez,Diana
Musleh,Maher
Bustamante,Marco
Stambuk,Juan
Pisano,Raul
Valladares,Hector
Lanzarini,Enrique
Chiong,Hector
Suazo,Jose
Quiñones,Luis A.
Varela,Nelson M.
Castro,V. Gonzalo
Jara,Lilian
Berger,Zoltan
author_sort Gonzalez–Hormazabal,Patricio
title NOD1 rs2075820 (p.E266K) polymorphism is associated with gastric cancer among individuals infected with cagPAI–positive H. pylori
title_short NOD1 rs2075820 (p.E266K) polymorphism is associated with gastric cancer among individuals infected with cagPAI–positive H. pylori
title_full NOD1 rs2075820 (p.E266K) polymorphism is associated with gastric cancer among individuals infected with cagPAI–positive H. pylori
title_fullStr NOD1 rs2075820 (p.E266K) polymorphism is associated with gastric cancer among individuals infected with cagPAI–positive H. pylori
title_full_unstemmed NOD1 rs2075820 (p.E266K) polymorphism is associated with gastric cancer among individuals infected with cagPAI–positive H. pylori
title_sort nod1 rs2075820 (p.e266k) polymorphism is associated with gastric cancer among individuals infected with cagpai–positive h. pylori
publisher Sociedad de Biología de Chile
publishDate 2021
url http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602021000100213
work_keys_str_mv AT gonzalez8211hormazabalpatricio nod1rs2075820pe266kpolymorphismisassociatedwithgastriccanceramongindividualsinfectedwithcagpai8211positivehpylori
AT pelaezdiana nod1rs2075820pe266kpolymorphismisassociatedwithgastriccanceramongindividualsinfectedwithcagpai8211positivehpylori
AT muslehmaher nod1rs2075820pe266kpolymorphismisassociatedwithgastriccanceramongindividualsinfectedwithcagpai8211positivehpylori
AT bustamantemarco nod1rs2075820pe266kpolymorphismisassociatedwithgastriccanceramongindividualsinfectedwithcagpai8211positivehpylori
AT stambukjuan nod1rs2075820pe266kpolymorphismisassociatedwithgastriccanceramongindividualsinfectedwithcagpai8211positivehpylori
AT pisanoraul nod1rs2075820pe266kpolymorphismisassociatedwithgastriccanceramongindividualsinfectedwithcagpai8211positivehpylori
AT valladareshector nod1rs2075820pe266kpolymorphismisassociatedwithgastriccanceramongindividualsinfectedwithcagpai8211positivehpylori
AT lanzarinienrique nod1rs2075820pe266kpolymorphismisassociatedwithgastriccanceramongindividualsinfectedwithcagpai8211positivehpylori
AT chionghector nod1rs2075820pe266kpolymorphismisassociatedwithgastriccanceramongindividualsinfectedwithcagpai8211positivehpylori
AT suazojose nod1rs2075820pe266kpolymorphismisassociatedwithgastriccanceramongindividualsinfectedwithcagpai8211positivehpylori
AT quinonesluisa nod1rs2075820pe266kpolymorphismisassociatedwithgastriccanceramongindividualsinfectedwithcagpai8211positivehpylori
AT varelanelsonm nod1rs2075820pe266kpolymorphismisassociatedwithgastriccanceramongindividualsinfectedwithcagpai8211positivehpylori
AT castrovgonzalo nod1rs2075820pe266kpolymorphismisassociatedwithgastriccanceramongindividualsinfectedwithcagpai8211positivehpylori
AT jaralilian nod1rs2075820pe266kpolymorphismisassociatedwithgastriccanceramongindividualsinfectedwithcagpai8211positivehpylori
AT bergerzoltan nod1rs2075820pe266kpolymorphismisassociatedwithgastriccanceramongindividualsinfectedwithcagpai8211positivehpylori
_version_ 1718441616427974656

Ejemplares similares