Demethylzeylasteral (T-96) initiates extrinsic apoptosis against prostate cancer cells by inducing ROS-mediated ER stress and suppressing autophagic flux

Demethylzeylasteral (T-96) initiates extrinsic apoptosis against prostate cancer cells by inducing ROS-mediated ER stress and suppressing autophagic flux

Abstract Background: Demethylzeylasteral (T-96) is a pharmacologically active triterpenoid monomer extracted from Tripterygium wilfordii Hook F (TWHF) that has been reported to exhibit anti-neoplastic effects against several types of cancer cells. However, the potential anti-tumour effects of T-96...

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Main Authors: Yang,Dong-lin, Zhang,Ya-jun, He,Liu-jun, Hu,Chun-sheng, Gao,Li-xia, Huang,Jiu-hong, Tang,Yan, Luo,Jie, Tang,Dian-yong, Chen,Zhong-zhu
Language:English
Published: Sociedad de Biología de Chile 2021
Subjects:
T-96
CaP
ER stress
Apoptosis
Autophagic flux
Cisplatin
Online Access:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602021000100222
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