WR2721 INTESTINAL RADIOPROTECTION: MORPHOMETRICAL ANALYSIS

Taking into account the great sensitivity of the intestinal mucosa to X irradiation we aimed at investigating the radioprotection afforded by the S-2-(3-aminopropylamino) ethylphosphorothioic acid (WR2721) on the mice rectum exposed to a single whole body X ray dose of 7 Gy and sacrificed at 1, 3, 6...

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Autores principales:	Imoto Egami,Mizue, Régis Silva,Maria Regina, Comodo Segreto,Helena Regina, Araújo Segreto,Roberto, Rodrigues de Paiva,Elias
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 1997
Materias:	Mouse Rectum Radioprotector
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-98681997000200005
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spelling	oai:scielo:S0716-986819970002000052001-11-06WR2721 INTESTINAL RADIOPROTECTION: MORPHOMETRICAL ANALYSISImoto Egami,MizueRégis Silva,Maria ReginaComodo Segreto,Helena ReginaAraújo Segreto,RobertoRodrigues de Paiva,Elias Mouse Rectum Radioprotector Taking into account the great sensitivity of the intestinal mucosa to X irradiation we aimed at investigating the radioprotection afforded by the S-2-(3-aminopropylamino) ethylphosphorothioic acid (WR2721) on the mice rectum exposed to a single whole body X ray dose of 7 Gy and sacrificed at 1, 3, 6 and 10 days after irradiation. Comparing the data of protected group with those of the unprotected one the following features were observed in the first one: statistically significant increase of both crypt cells per crypt (CrC/Cr) at 1, 3, 6 and 10 days after irradiation and of mitotic figures per crypt (MF/Cr) at 3, 6 and 10 days post exposure. In this way it became clear that these morphometric parameters allowed the estimation of WR2721 rectum protection through the crypt cellularity and epithelial cell kineticsinfo:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaRevista chilena de anatomía v.15 n.2 19971997-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-98681997000200005en10.4067/S0716-98681997000200005
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Mouse Rectum Radioprotector
spellingShingle	Mouse Rectum Radioprotector Imoto Egami,Mizue Régis Silva,Maria Regina Comodo Segreto,Helena Regina Araújo Segreto,Roberto Rodrigues de Paiva,Elias WR2721 INTESTINAL RADIOPROTECTION: MORPHOMETRICAL ANALYSIS
description	Taking into account the great sensitivity of the intestinal mucosa to X irradiation we aimed at investigating the radioprotection afforded by the S-2-(3-aminopropylamino) ethylphosphorothioic acid (WR2721) on the mice rectum exposed to a single whole body X ray dose of 7 Gy and sacrificed at 1, 3, 6 and 10 days after irradiation. Comparing the data of protected group with those of the unprotected one the following features were observed in the first one: statistically significant increase of both crypt cells per crypt (CrC/Cr) at 1, 3, 6 and 10 days after irradiation and of mitotic figures per crypt (MF/Cr) at 3, 6 and 10 days post exposure. In this way it became clear that these morphometric parameters allowed the estimation of WR2721 rectum protection through the crypt cellularity and epithelial cell kinetics
author	Imoto Egami,Mizue Régis Silva,Maria Regina Comodo Segreto,Helena Regina Araújo Segreto,Roberto Rodrigues de Paiva,Elias
author_facet	Imoto Egami,Mizue Régis Silva,Maria Regina Comodo Segreto,Helena Regina Araújo Segreto,Roberto Rodrigues de Paiva,Elias
author_sort	Imoto Egami,Mizue
title	WR2721 INTESTINAL RADIOPROTECTION: MORPHOMETRICAL ANALYSIS
title_short	WR2721 INTESTINAL RADIOPROTECTION: MORPHOMETRICAL ANALYSIS
title_full	WR2721 INTESTINAL RADIOPROTECTION: MORPHOMETRICAL ANALYSIS
title_fullStr	WR2721 INTESTINAL RADIOPROTECTION: MORPHOMETRICAL ANALYSIS
title_full_unstemmed	WR2721 INTESTINAL RADIOPROTECTION: MORPHOMETRICAL ANALYSIS
title_sort	wr2721 intestinal radioprotection: morphometrical analysis
publisher	Sociedad Chilena de Anatomía
publishDate	1997
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-98681997000200005
work_keys_str_mv	AT imotoegamimizue wr2721intestinalradioprotectionmorphometricalanalysis AT regissilvamariaregina wr2721intestinalradioprotectionmorphometricalanalysis AT comodosegretohelenaregina wr2721intestinalradioprotectionmorphometricalanalysis AT araujosegretoroberto wr2721intestinalradioprotectionmorphometricalanalysis AT rodriguesdepaivaelias wr2721intestinalradioprotectionmorphometricalanalysis
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WR2721 INTESTINAL RADIOPROTECTION: MORPHOMETRICAL ANALYSIS

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