KERATINAS: BIOLOGIA CELULAR Y SIGNIFICADO FUNCIONAL NORMAL Y PATOLOGICO
Keratins are intermediate filaments of the cytoskeleton of epithelial cells. They express themselves in simple (Ks. 7, 8, 18, 19 y 20) or stratitified epithelia (Ks. 1, 2, 5, 9, 10, 11, 16). The different expression of these multigenic cytoskeletal proteins is related to cell specific differentiatio...
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| Lenguaje: | Spanish / Castilian |
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Sociedad Chilena de Anatomía
1998
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| Acceso en línea: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-98681998000100003 |
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oai:scielo:S0716-986819980001000031999-11-26KERATINAS: BIOLOGIA CELULAR Y SIGNIFICADO FUNCIONAL NORMAL Y PATOLOGICORojas,MarianaMartínez-García,FranciscoCobo,PazPalacios,JoséNistal,ManuelRegadera,Javier Keratins Cytokeratins Cytoskeleton Intermediate filaments Histology Pathology Keratins are intermediate filaments of the cytoskeleton of epithelial cells. They express themselves in simple (Ks. 7, 8, 18, 19 y 20) or stratitified epithelia (Ks. 1, 2, 5, 9, 10, 11, 16). The different expression of these multigenic cytoskeletal proteins is related to cell specific differentiation programs (OSBORN & WEBER, 1983; NAGLE, 1988); For these reasons the analysis of keratins are very relevant for the study of new aspects of histology, histopathology and developmental biology. Moreover, evaluation of keratins by immunofluorescent or immunohistochemistry is useful for the proper identification and characterization of normal, displasic and neoplasic cells (OSBORN & WEBER, 1983; NAGLE). The different patterns of expression of keratins are related to the degree of differentiation of inmature epithelial cells, as well as the degree of differentiation of malignant tumours (FUCHS & GREEN, 1980; FRANKE et al., 1981b; MOLL et al, 1892a; SCHAAFSMA & RAMAEKERS, 1994). Lastly, evaluation of the changes of immunoexpresion of keratins is useful for the differential diagnosis between typical and atypical squamous metaplasia, including moderate and severe epithelial displasia and intraepithelial neoplasia -formerly known as carcinoma in situ- (MOLL et al., 1982a; TSENG et al., 1982; QUINLAN et al., 1985; HUSZAR et al., 1986; GIGI-LEITNER et al; HEID et al.,1988)info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaRevista chilena de anatomía v.16 n.1 19981998-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-98681998000100003es10.4067/S0716-98681998000100003 |
| institution |
Scielo Chile |
| collection |
Scielo Chile |
| language |
Spanish / Castilian |
| topic |
Keratins Cytokeratins Cytoskeleton Intermediate filaments Histology Pathology |
| spellingShingle |
Keratins Cytokeratins Cytoskeleton Intermediate filaments Histology Pathology Rojas,Mariana Martínez-García,Francisco Cobo,Paz Palacios,José Nistal,Manuel Regadera,Javier KERATINAS: BIOLOGIA CELULAR Y SIGNIFICADO FUNCIONAL NORMAL Y PATOLOGICO |
| description |
Keratins are intermediate filaments of the cytoskeleton of epithelial cells. They express themselves in simple (Ks. 7, 8, 18, 19 y 20) or stratitified epithelia (Ks. 1, 2, 5, 9, 10, 11, 16). The different expression of these multigenic cytoskeletal proteins is related to cell specific differentiation programs (OSBORN & WEBER, 1983; NAGLE, 1988); For these reasons the analysis of keratins are very relevant for the study of new aspects of histology, histopathology and developmental biology. Moreover, evaluation of keratins by immunofluorescent or immunohistochemistry is useful for the proper identification and characterization of normal, displasic and neoplasic cells (OSBORN & WEBER, 1983; NAGLE). The different patterns of expression of keratins are related to the degree of differentiation of inmature epithelial cells, as well as the degree of differentiation of malignant tumours (FUCHS & GREEN, 1980; FRANKE et al., 1981b; MOLL et al, 1892a; SCHAAFSMA & RAMAEKERS, 1994). Lastly, evaluation of the changes of immunoexpresion of keratins is useful for the differential diagnosis between typical and atypical squamous metaplasia, including moderate and severe epithelial displasia and intraepithelial neoplasia -formerly known as carcinoma in situ- (MOLL et al., 1982a; TSENG et al., 1982; QUINLAN et al., 1985; HUSZAR et al., 1986; GIGI-LEITNER et al; HEID et al.,1988) |
| author |
Rojas,Mariana Martínez-García,Francisco Cobo,Paz Palacios,José Nistal,Manuel Regadera,Javier |
| author_facet |
Rojas,Mariana Martínez-García,Francisco Cobo,Paz Palacios,José Nistal,Manuel Regadera,Javier |
| author_sort |
Rojas,Mariana |
| title |
KERATINAS: BIOLOGIA CELULAR Y SIGNIFICADO FUNCIONAL NORMAL Y PATOLOGICO |
| title_short |
KERATINAS: BIOLOGIA CELULAR Y SIGNIFICADO FUNCIONAL NORMAL Y PATOLOGICO |
| title_full |
KERATINAS: BIOLOGIA CELULAR Y SIGNIFICADO FUNCIONAL NORMAL Y PATOLOGICO |
| title_fullStr |
KERATINAS: BIOLOGIA CELULAR Y SIGNIFICADO FUNCIONAL NORMAL Y PATOLOGICO |
| title_full_unstemmed |
KERATINAS: BIOLOGIA CELULAR Y SIGNIFICADO FUNCIONAL NORMAL Y PATOLOGICO |
| title_sort |
keratinas: biologia celular y significado funcional normal y patologico |
| publisher |
Sociedad Chilena de Anatomía |
| publishDate |
1998 |
| url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-98681998000100003 |
| work_keys_str_mv |
AT rojasmariana keratinasbiologiacelularysignificadofuncionalnormalypatologico AT martinezgarciafrancisco keratinasbiologiacelularysignificadofuncionalnormalypatologico AT cobopaz keratinasbiologiacelularysignificadofuncionalnormalypatologico AT palaciosjose keratinasbiologiacelularysignificadofuncionalnormalypatologico AT nistalmanuel keratinasbiologiacelularysignificadofuncionalnormalypatologico AT regaderajavier keratinasbiologiacelularysignificadofuncionalnormalypatologico |
| _version_ |
1718441629891690496 |