EFFECTS OF LOW-DOSE EXPOSURE OF RAT FETUSES PANCREAS TO METHYLMERCURY.: MORPHOMETRIC AND STEREOLOGIC STUDIES
Methylmercury chloride (20 mg/kg body weight), when administered orally to Wistar rats on day 10 of pregnancy, originated smaller fetuses and placentas. Death and resorptions were present and no gross malformations were seen. Histologically, the larger pancreatic acini of treated fetus showed irregu...
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| Autores principales: | , , , , , |
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| Lenguaje: | English |
| Publicado: |
Sociedad Chilena de Anatomía
1998
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| Materias: | |
| Acceso en línea: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-98681998000200002 |
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| Sumario: | Methylmercury chloride (20 mg/kg body weight), when administered orally to Wistar rats on day 10 of pregnancy, originated smaller fetuses and placentas. Death and resorptions were present and no gross malformations were seen. Histologically, the larger pancreatic acini of treated fetus showed irregular shape with larger pyknotic nuclei. The nuclei varied in size and shape. The lumen was small. In the faintly eosinophilic cytoplasm of the cells less numerous secretory granules were present. The ducts were disorganized and presented larger nuclei. The pancreatic islets were immature and less organized. The data were analyzed with morphometric and stereologic techniques. |
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