EFFECTS OF LOW-DOSE EXPOSURE OF RAT FETUSES PANCREAS TO METHYLMERCURY.: MORPHOMETRIC AND STEREOLOGIC STUDIES

Methylmercury chloride (20 mg/kg body weight), when administered orally to Wistar rats on day 10 of pregnancy, originated smaller fetuses and placentas. Death and resorptions were present and no gross malformations were seen. Histologically, the larger pancreatic acini of treated fetus showed irregu...

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Autores principales:	Mendes,Glória E. F., Azoubel,Reinaldo, Lopes,Ruberval A., Sala,Miguel A., de Lacerda,Suzie A., Silva Júnior,Amadeu R.
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 1998
Materias:	Methylmercury Rat Fetus Pancreas Morphometry Stereology
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-98681998000200002
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spelling	oai:scielo:S0716-986819980002000022005-10-04EFFECTS OF LOW-DOSE EXPOSURE OF RAT FETUSES PANCREAS TO METHYLMERCURY.: MORPHOMETRIC AND STEREOLOGIC STUDIESMendes,Glória E. F.Azoubel,ReinaldoLopes,Ruberval A.Sala,Miguel A.de Lacerda,Suzie A.Silva Júnior,Amadeu R. Methylmercury Rat Fetus Pancreas Morphometry Stereology Methylmercury chloride (20 mg/kg body weight), when administered orally to Wistar rats on day 10 of pregnancy, originated smaller fetuses and placentas. Death and resorptions were present and no gross malformations were seen. Histologically, the larger pancreatic acini of treated fetus showed irregular shape with larger pyknotic nuclei. The nuclei varied in size and shape. The lumen was small. In the faintly eosinophilic cytoplasm of the cells less numerous secretory granules were present. The ducts were disorganized and presented larger nuclei. The pancreatic islets were immature and less organized. The data were analyzed with morphometric and stereologic techniques.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaRevista chilena de anatomía v.16 n.2 19981998-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-98681998000200002en10.4067/S0716-98681998000200002
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Methylmercury Rat Fetus Pancreas Morphometry Stereology
spellingShingle	Methylmercury Rat Fetus Pancreas Morphometry Stereology Mendes,Glória E. F. Azoubel,Reinaldo Lopes,Ruberval A. Sala,Miguel A. de Lacerda,Suzie A. Silva Júnior,Amadeu R. EFFECTS OF LOW-DOSE EXPOSURE OF RAT FETUSES PANCREAS TO METHYLMERCURY.: MORPHOMETRIC AND STEREOLOGIC STUDIES
description	Methylmercury chloride (20 mg/kg body weight), when administered orally to Wistar rats on day 10 of pregnancy, originated smaller fetuses and placentas. Death and resorptions were present and no gross malformations were seen. Histologically, the larger pancreatic acini of treated fetus showed irregular shape with larger pyknotic nuclei. The nuclei varied in size and shape. The lumen was small. In the faintly eosinophilic cytoplasm of the cells less numerous secretory granules were present. The ducts were disorganized and presented larger nuclei. The pancreatic islets were immature and less organized. The data were analyzed with morphometric and stereologic techniques.
author	Mendes,Glória E. F. Azoubel,Reinaldo Lopes,Ruberval A. Sala,Miguel A. de Lacerda,Suzie A. Silva Júnior,Amadeu R.
author_facet	Mendes,Glória E. F. Azoubel,Reinaldo Lopes,Ruberval A. Sala,Miguel A. de Lacerda,Suzie A. Silva Júnior,Amadeu R.
author_sort	Mendes,Glória E. F.
title	EFFECTS OF LOW-DOSE EXPOSURE OF RAT FETUSES PANCREAS TO METHYLMERCURY.: MORPHOMETRIC AND STEREOLOGIC STUDIES
title_short	EFFECTS OF LOW-DOSE EXPOSURE OF RAT FETUSES PANCREAS TO METHYLMERCURY.: MORPHOMETRIC AND STEREOLOGIC STUDIES
title_full	EFFECTS OF LOW-DOSE EXPOSURE OF RAT FETUSES PANCREAS TO METHYLMERCURY.: MORPHOMETRIC AND STEREOLOGIC STUDIES
title_fullStr	EFFECTS OF LOW-DOSE EXPOSURE OF RAT FETUSES PANCREAS TO METHYLMERCURY.: MORPHOMETRIC AND STEREOLOGIC STUDIES
title_full_unstemmed	EFFECTS OF LOW-DOSE EXPOSURE OF RAT FETUSES PANCREAS TO METHYLMERCURY.: MORPHOMETRIC AND STEREOLOGIC STUDIES
title_sort	effects of low-dose exposure of rat fetuses pancreas to methylmercury.: morphometric and stereologic studies
publisher	Sociedad Chilena de Anatomía
publishDate	1998
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-98681998000200002
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EFFECTS OF LOW-DOSE EXPOSURE OF RAT FETUSES PANCREAS TO METHYLMERCURY.: MORPHOMETRIC AND STEREOLOGIC STUDIES

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