Hepatic and Renal Effects of Propoxyphene Napsylate on Pregnant Rats

As a less potent opioid analgesic and CNS depressant than morphine, propoxyphene abuse constitutes a potential risk among pregnant women. Since literature data indicate the possibility of serious side effects on liver compartment, in this work we examined the effects the chronic administration of th...

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Autores principales:	Rocha Mendes,Eliane Terezinha, Simões,Manuel de Jesus, Alves Mora,Oswaldo, Martins Oliveira-Filho,Ricardo, Kulay Jr.,Luiz
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2000
Materias:	Propoxyphene Toxycology Kidney Liver Rat Pregnancy
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-98682000000200007
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spelling	oai:scielo:S0716-986820000002000072005-10-04Hepatic and Renal Effects of Propoxyphene Napsylate on Pregnant RatsRocha Mendes,Eliane TerezinhaSimões,Manuel de JesusAlves Mora,OswaldoMartins Oliveira-Filho,RicardoKulay Jr.,Luiz Propoxyphene Toxycology Kidney Liver Rat Pregnancy As a less potent opioid analgesic and CNS depressant than morphine, propoxyphene abuse constitutes a potential risk among pregnant women. Since literature data indicate the possibility of serious side effects on liver compartment, in this work we examined the effects the chronic administration of this drug on both pregnant rats and their concepts. Female rats were treated during the entire pregnancy (from day 0 up to day 20) with 5, 15 or 45 mg/kg of propoxyphene napsylate once daily, by gavage. Controls received the drug vehicle. At term, samples from both maternal and foetal kidneys and livers were taken and prepared for optical and electron microscopy examination. Upon optical microscopy or electron microscopy examination, no morphological alterations were seen on either maternal or foetal livers of propoxyphene-treated pregnant rats. However, maternal and foetal kidneys showed signs of toxicity mainly in the group of rats treated with the highest dose of the drug, especially at the proximal convoluted tubules. Our results suggest that, in the rat, the physiological modifications inherent to pregnancy shifted the main focus of toxicity of propoxyphene from the liver to the kidney. The mechanisms involved in such phenomenon are at present unresolvedinfo:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaRevista chilena de anatomía v.18 n.2 20002000-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-98682000000200007en10.4067/S0716-98682000000200007
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Propoxyphene Toxycology Kidney Liver Rat Pregnancy
spellingShingle	Propoxyphene Toxycology Kidney Liver Rat Pregnancy Rocha Mendes,Eliane Terezinha Simões,Manuel de Jesus Alves Mora,Oswaldo Martins Oliveira-Filho,Ricardo Kulay Jr.,Luiz Hepatic and Renal Effects of Propoxyphene Napsylate on Pregnant Rats
description	As a less potent opioid analgesic and CNS depressant than morphine, propoxyphene abuse constitutes a potential risk among pregnant women. Since literature data indicate the possibility of serious side effects on liver compartment, in this work we examined the effects the chronic administration of this drug on both pregnant rats and their concepts. Female rats were treated during the entire pregnancy (from day 0 up to day 20) with 5, 15 or 45 mg/kg of propoxyphene napsylate once daily, by gavage. Controls received the drug vehicle. At term, samples from both maternal and foetal kidneys and livers were taken and prepared for optical and electron microscopy examination. Upon optical microscopy or electron microscopy examination, no morphological alterations were seen on either maternal or foetal livers of propoxyphene-treated pregnant rats. However, maternal and foetal kidneys showed signs of toxicity mainly in the group of rats treated with the highest dose of the drug, especially at the proximal convoluted tubules. Our results suggest that, in the rat, the physiological modifications inherent to pregnancy shifted the main focus of toxicity of propoxyphene from the liver to the kidney. The mechanisms involved in such phenomenon are at present unresolved
author	Rocha Mendes,Eliane Terezinha Simões,Manuel de Jesus Alves Mora,Oswaldo Martins Oliveira-Filho,Ricardo Kulay Jr.,Luiz
author_facet	Rocha Mendes,Eliane Terezinha Simões,Manuel de Jesus Alves Mora,Oswaldo Martins Oliveira-Filho,Ricardo Kulay Jr.,Luiz
author_sort	Rocha Mendes,Eliane Terezinha
title	Hepatic and Renal Effects of Propoxyphene Napsylate on Pregnant Rats
title_short	Hepatic and Renal Effects of Propoxyphene Napsylate on Pregnant Rats
title_full	Hepatic and Renal Effects of Propoxyphene Napsylate on Pregnant Rats
title_fullStr	Hepatic and Renal Effects of Propoxyphene Napsylate on Pregnant Rats
title_full_unstemmed	Hepatic and Renal Effects of Propoxyphene Napsylate on Pregnant Rats
title_sort	hepatic and renal effects of propoxyphene napsylate on pregnant rats
publisher	Sociedad Chilena de Anatomía
publishDate	2000
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-98682000000200007
work_keys_str_mv	AT rochamendeselianeterezinha hepaticandrenaleffectsofpropoxyphenenapsylateonpregnantrats AT simoesmanueldejesus hepaticandrenaleffectsofpropoxyphenenapsylateonpregnantrats AT alvesmoraoswaldo hepaticandrenaleffectsofpropoxyphenenapsylateonpregnantrats AT martinsoliveirafilhoricardo hepaticandrenaleffectsofpropoxyphenenapsylateonpregnantrats AT kulayjrluiz hepaticandrenaleffectsofpropoxyphenenapsylateonpregnantrats
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Hepatic and Renal Effects of Propoxyphene Napsylate on Pregnant Rats

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