ULTRASTRUCTURAL ALTERATIONS OF THE PAROTID GLANDS OF RATS (Rattus norvegicus) SUBMITTED TO EXPERIMENTAL CHRONIC ALCOHOLISM

Adult male rats (lineage Wistar) were alcoholized with ethanol diluted to 6%, after a brief adaptation period with weekly growing doses of ethanol to 2%, 4% and 6%. After a 10 and 15-month period of experiment, 4 animals of each group _ control (C) and alcoholized (A) _ were intraperitoneally anesth...

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Autores principales:	Tirapelli,L. F., Tirapelli,D. P.C., Schimming,B.C.
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2001
Materias:	Parotid gland Alcoholism Rats Ultrastructural alterations
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-98682001000200009
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spelling	oai:scielo:S0716-986820010002000092001-11-30ULTRASTRUCTURAL ALTERATIONS OF THE PAROTID GLANDS OF RATS (Rattus norvegicus) SUBMITTED TO EXPERIMENTAL CHRONIC ALCOHOLISMTirapelli,L. F.Tirapelli,D. P.C.Schimming,B.C. Parotid gland Alcoholism Rats Ultrastructural alterations Adult male rats (lineage Wistar) were alcoholized with ethanol diluted to 6%, after a brief adaptation period with weekly growing doses of ethanol to 2%, 4% and 6%. After a 10 and 15-month period of experiment, 4 animals of each group _ control (C) and alcoholized (A) _ were intraperitoneally anesthetized with 3% Hypnol and fixed by perfusion with 2,5% glutaraldehyde. Samples of parotid glands were collected and examined in an Transmission Electron Microscope. Gradual ultrastructural alterations were observed in those animals during the whole experiment: dilation of the cisterns of the Golgi complex, presence of digestive vacuoles and a great amount of empty vesicles in the entire cytoplasm, an increase and accumulation of secondary lysosomes, besides an enlargement of the intercellular space, between basolateral interdigitations of the cells, as well as in the conjunctive tissue. The described morphologic alterations are due, probably, to disturbances in the hydroelectrolitic homeostasis in the saliva production, therefore contributing to serious morpho-functional disturbances of those glands in alcoholic individuals. No alteration could be observed in the animals of the control groupinfo:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaRevista chilena de anatomía v.19 n.2 20012001-08-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-98682001000200009en10.4067/S0716-98682001000200009
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Parotid gland Alcoholism Rats Ultrastructural alterations
spellingShingle	Parotid gland Alcoholism Rats Ultrastructural alterations Tirapelli,L. F. Tirapelli,D. P.C. Schimming,B.C. ULTRASTRUCTURAL ALTERATIONS OF THE PAROTID GLANDS OF RATS (Rattus norvegicus) SUBMITTED TO EXPERIMENTAL CHRONIC ALCOHOLISM
description	Adult male rats (lineage Wistar) were alcoholized with ethanol diluted to 6%, after a brief adaptation period with weekly growing doses of ethanol to 2%, 4% and 6%. After a 10 and 15-month period of experiment, 4 animals of each group _ control (C) and alcoholized (A) _ were intraperitoneally anesthetized with 3% Hypnol and fixed by perfusion with 2,5% glutaraldehyde. Samples of parotid glands were collected and examined in an Transmission Electron Microscope. Gradual ultrastructural alterations were observed in those animals during the whole experiment: dilation of the cisterns of the Golgi complex, presence of digestive vacuoles and a great amount of empty vesicles in the entire cytoplasm, an increase and accumulation of secondary lysosomes, besides an enlargement of the intercellular space, between basolateral interdigitations of the cells, as well as in the conjunctive tissue. The described morphologic alterations are due, probably, to disturbances in the hydroelectrolitic homeostasis in the saliva production, therefore contributing to serious morpho-functional disturbances of those glands in alcoholic individuals. No alteration could be observed in the animals of the control group
author	Tirapelli,L. F. Tirapelli,D. P.C. Schimming,B.C.
author_facet	Tirapelli,L. F. Tirapelli,D. P.C. Schimming,B.C.
author_sort	Tirapelli,L. F.
title	ULTRASTRUCTURAL ALTERATIONS OF THE PAROTID GLANDS OF RATS (Rattus norvegicus) SUBMITTED TO EXPERIMENTAL CHRONIC ALCOHOLISM
title_short	ULTRASTRUCTURAL ALTERATIONS OF THE PAROTID GLANDS OF RATS (Rattus norvegicus) SUBMITTED TO EXPERIMENTAL CHRONIC ALCOHOLISM
title_full	ULTRASTRUCTURAL ALTERATIONS OF THE PAROTID GLANDS OF RATS (Rattus norvegicus) SUBMITTED TO EXPERIMENTAL CHRONIC ALCOHOLISM
title_fullStr	ULTRASTRUCTURAL ALTERATIONS OF THE PAROTID GLANDS OF RATS (Rattus norvegicus) SUBMITTED TO EXPERIMENTAL CHRONIC ALCOHOLISM
title_full_unstemmed	ULTRASTRUCTURAL ALTERATIONS OF THE PAROTID GLANDS OF RATS (Rattus norvegicus) SUBMITTED TO EXPERIMENTAL CHRONIC ALCOHOLISM
title_sort	ultrastructural alterations of the parotid glands of rats (rattus norvegicus) submitted to experimental chronic alcoholism
publisher	Sociedad Chilena de Anatomía
publishDate	2001
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-98682001000200009
work_keys_str_mv	AT tirapellilf ultrastructuralalterationsoftheparotidglandsofratsrattusnorvegicussubmittedtoexperimentalchronicalcoholism AT tirapellidpc ultrastructuralalterationsoftheparotidglandsofratsrattusnorvegicussubmittedtoexperimentalchronicalcoholism AT schimmingbc ultrastructuralalterationsoftheparotidglandsofratsrattusnorvegicussubmittedtoexperimentalchronicalcoholism
_version_	1718441660777496576

ULTRASTRUCTURAL ALTERATIONS OF THE PAROTID GLANDS OF RATS (Rattus norvegicus) SUBMITTED TO EXPERIMENTAL CHRONIC ALCOHOLISM

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