ULTRASTRUCTURAL ALTERATIONS IN SUBMANDIBULAR GLANDS OF RATS (Rattus norvegicus) SUBMITTED TO EXPERIMENTAL CHRONIC ALCOHOLISM

The objective of this study was to analyze the submandibular glands of rats (Rattus norvegicus) submitted to experimental chronic alcoholism at electronic transmission microscopy. The experiment was programmed for a 15-month period, and in every five months, three animals from each group were sacrif...

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Autores principales:	Tirapelli,L. F, Tirapelli,D. P. C, Tamega,O. J
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2002
Materias:	Ultrastructural alteration Ethanol Submandibular gland Rats
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-98682002000100001
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spelling	oai:scielo:S0716-986820020001000012002-07-08ULTRASTRUCTURAL ALTERATIONS IN SUBMANDIBULAR GLANDS OF RATS (Rattus norvegicus) SUBMITTED TO EXPERIMENTAL CHRONIC ALCOHOLISMTirapelli,L. FTirapelli,D. P. CTamega,O. J Ultrastructural alteration Ethanol Submandibular gland Rats The objective of this study was to analyze the submandibular glands of rats (Rattus norvegicus) submitted to experimental chronic alcoholism at electronic transmission microscopy. The experiment was programmed for a 15-month period, and in every five months, three animals from each group were sacrificed. Twenty-seven male rats, with average weight of 300g, were used and divided into three experimental groups with the following characteristics: 1) alcoholic: received ethanol, daily, at 6% for 15 months; 2) isocaloric: received diluted sucrose at a concentration of 87.14 g/L, corresponding energetically to the caloric content of the alcoholic group; and 3) control: received tap water "ad libitum" as liquid diet. The animals were fed with the same amount of Purina ration as a conventional weekly solid diet. It was observed several ultrastructural alterations in the alcoholic animals mainly in seromucous cells: dilation and enlargement of Golgi complex cisterns; the presence of digestive vacuoles, a large number of electronlucent vesicles and an increase in intercellular space, an increase between basolateral interdigitation cell and an enlargement of connective tissue. It was observed at some cells of the intercalary ducts at a lower part of lateral membranes, only after 15-month treatment, the presence of wide and clear vesicles with electronlucent material located among cell secretion granules of granular ducts. No alterations were observed in the animals of the control and isocaloric groups as well as the other parts of glandular parenchyma of animals of the alcoholic groupinfo:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaRevista chilena de anatomía v.20 n.1 20022002-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-98682002000100001en10.4067/S0716-98682002000100001
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Ultrastructural alteration Ethanol Submandibular gland Rats
spellingShingle	Ultrastructural alteration Ethanol Submandibular gland Rats Tirapelli,L. F Tirapelli,D. P. C Tamega,O. J ULTRASTRUCTURAL ALTERATIONS IN SUBMANDIBULAR GLANDS OF RATS (Rattus norvegicus) SUBMITTED TO EXPERIMENTAL CHRONIC ALCOHOLISM
description	The objective of this study was to analyze the submandibular glands of rats (Rattus norvegicus) submitted to experimental chronic alcoholism at electronic transmission microscopy. The experiment was programmed for a 15-month period, and in every five months, three animals from each group were sacrificed. Twenty-seven male rats, with average weight of 300g, were used and divided into three experimental groups with the following characteristics: 1) alcoholic: received ethanol, daily, at 6% for 15 months; 2) isocaloric: received diluted sucrose at a concentration of 87.14 g/L, corresponding energetically to the caloric content of the alcoholic group; and 3) control: received tap water "ad libitum" as liquid diet. The animals were fed with the same amount of Purina ration as a conventional weekly solid diet. It was observed several ultrastructural alterations in the alcoholic animals mainly in seromucous cells: dilation and enlargement of Golgi complex cisterns; the presence of digestive vacuoles, a large number of electronlucent vesicles and an increase in intercellular space, an increase between basolateral interdigitation cell and an enlargement of connective tissue. It was observed at some cells of the intercalary ducts at a lower part of lateral membranes, only after 15-month treatment, the presence of wide and clear vesicles with electronlucent material located among cell secretion granules of granular ducts. No alterations were observed in the animals of the control and isocaloric groups as well as the other parts of glandular parenchyma of animals of the alcoholic group
author	Tirapelli,L. F Tirapelli,D. P. C Tamega,O. J
author_facet	Tirapelli,L. F Tirapelli,D. P. C Tamega,O. J
author_sort	Tirapelli,L. F
title	ULTRASTRUCTURAL ALTERATIONS IN SUBMANDIBULAR GLANDS OF RATS (Rattus norvegicus) SUBMITTED TO EXPERIMENTAL CHRONIC ALCOHOLISM
title_short	ULTRASTRUCTURAL ALTERATIONS IN SUBMANDIBULAR GLANDS OF RATS (Rattus norvegicus) SUBMITTED TO EXPERIMENTAL CHRONIC ALCOHOLISM
title_full	ULTRASTRUCTURAL ALTERATIONS IN SUBMANDIBULAR GLANDS OF RATS (Rattus norvegicus) SUBMITTED TO EXPERIMENTAL CHRONIC ALCOHOLISM
title_fullStr	ULTRASTRUCTURAL ALTERATIONS IN SUBMANDIBULAR GLANDS OF RATS (Rattus norvegicus) SUBMITTED TO EXPERIMENTAL CHRONIC ALCOHOLISM
title_full_unstemmed	ULTRASTRUCTURAL ALTERATIONS IN SUBMANDIBULAR GLANDS OF RATS (Rattus norvegicus) SUBMITTED TO EXPERIMENTAL CHRONIC ALCOHOLISM
title_sort	ultrastructural alterations in submandibular glands of rats (rattus norvegicus) submitted to experimental chronic alcoholism
publisher	Sociedad Chilena de Anatomía
publishDate	2002
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-98682002000100001
work_keys_str_mv	AT tirapellilf ultrastructuralalterationsinsubmandibularglandsofratsrattusnorvegicussubmittedtoexperimentalchronicalcoholism AT tirapellidpc ultrastructuralalterationsinsubmandibularglandsofratsrattusnorvegicussubmittedtoexperimentalchronicalcoholism AT tamegaoj ultrastructuralalterationsinsubmandibularglandsofratsrattusnorvegicussubmittedtoexperimentalchronicalcoholism
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ULTRASTRUCTURAL ALTERATIONS IN SUBMANDIBULAR GLANDS OF RATS (Rattus norvegicus) SUBMITTED TO EXPERIMENTAL CHRONIC ALCOHOLISM

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