ACTIONS OF MEFENAMIC ACID ON PREGNANT ALBINO RATS

Misuse and abuse of the non-steroidal anti-inflammatory and analgesic mefenamic acid among pregnant women in developing coutries constitute a matter of medical concern, mainly as a function of the potentially serious side effects of that drug, notably at the digestive system level. Female rats were...

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Autores principales:	Fernandes,Guilherme L., Simões,Manuel J., Baracat,Edmund C., Espiridião,Sílvia, Oliveira-Filho,Ricardo M., Kulay Jr.,Luiz
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2002
Materias:	Mefenamic acid Toxycology Rat Pregnancy
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-98682002000200009
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spelling	oai:scielo:S0716-986820020002000092005-10-04ACTIONS OF MEFENAMIC ACID ON PREGNANT ALBINO RATSFernandes,Guilherme L.Simões,Manuel J.Baracat,Edmund C.Espiridião,SílviaOliveira-Filho,Ricardo M.Kulay Jr.,Luiz Mefenamic acid Toxycology Rat Pregnancy Misuse and abuse of the non-steroidal anti-inflammatory and analgesic mefenamic acid among pregnant women in developing coutries constitute a matter of medical concern, mainly as a function of the potentially serious side effects of that drug, notably at the digestive system level. Female rats were treated during the entire pregnancy period (from day 0 up to day 20) with 5, 15, or 45 mg/kg of mefenamic acid (MA) once daily, by gavage. Controls received the drug vehicle. We observed that there was a slight yet significant impairment of maternal body weight gain of the animals treated with the two highest doses of MA. Although the drug was proven to exert deleterious effects on kidney and liver metabolic functions, no gross signs of renal or hepatic toxicity were detected in our animals and in their concepts. The digestive effects would be presumably caused by the inhibitory actions of MA on the luminal fluid movement and are accounted for by the observed body weight loss during pregnancy.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaRevista chilena de anatomía v.20 n.2 20022002-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-98682002000200009en10.4067/S0716-98682002000200009
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Mefenamic acid Toxycology Rat Pregnancy
spellingShingle	Mefenamic acid Toxycology Rat Pregnancy Fernandes,Guilherme L. Simões,Manuel J. Baracat,Edmund C. Espiridião,Sílvia Oliveira-Filho,Ricardo M. Kulay Jr.,Luiz ACTIONS OF MEFENAMIC ACID ON PREGNANT ALBINO RATS
description	Misuse and abuse of the non-steroidal anti-inflammatory and analgesic mefenamic acid among pregnant women in developing coutries constitute a matter of medical concern, mainly as a function of the potentially serious side effects of that drug, notably at the digestive system level. Female rats were treated during the entire pregnancy period (from day 0 up to day 20) with 5, 15, or 45 mg/kg of mefenamic acid (MA) once daily, by gavage. Controls received the drug vehicle. We observed that there was a slight yet significant impairment of maternal body weight gain of the animals treated with the two highest doses of MA. Although the drug was proven to exert deleterious effects on kidney and liver metabolic functions, no gross signs of renal or hepatic toxicity were detected in our animals and in their concepts. The digestive effects would be presumably caused by the inhibitory actions of MA on the luminal fluid movement and are accounted for by the observed body weight loss during pregnancy.
author	Fernandes,Guilherme L. Simões,Manuel J. Baracat,Edmund C. Espiridião,Sílvia Oliveira-Filho,Ricardo M. Kulay Jr.,Luiz
author_facet	Fernandes,Guilherme L. Simões,Manuel J. Baracat,Edmund C. Espiridião,Sílvia Oliveira-Filho,Ricardo M. Kulay Jr.,Luiz
author_sort	Fernandes,Guilherme L.
title	ACTIONS OF MEFENAMIC ACID ON PREGNANT ALBINO RATS
title_short	ACTIONS OF MEFENAMIC ACID ON PREGNANT ALBINO RATS
title_full	ACTIONS OF MEFENAMIC ACID ON PREGNANT ALBINO RATS
title_fullStr	ACTIONS OF MEFENAMIC ACID ON PREGNANT ALBINO RATS
title_full_unstemmed	ACTIONS OF MEFENAMIC ACID ON PREGNANT ALBINO RATS
title_sort	actions of mefenamic acid on pregnant albino rats
publisher	Sociedad Chilena de Anatomía
publishDate	2002
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-98682002000200009
work_keys_str_mv	AT fernandesguilhermel actionsofmefenamicacidonpregnantalbinorats AT simoesmanuelj actionsofmefenamicacidonpregnantalbinorats AT baracatedmundc actionsofmefenamicacidonpregnantalbinorats AT espiridiaosilvia actionsofmefenamicacidonpregnantalbinorats AT oliveirafilhoricardom actionsofmefenamicacidonpregnantalbinorats AT kulayjrluiz actionsofmefenamicacidonpregnantalbinorats
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ACTIONS OF MEFENAMIC ACID ON PREGNANT ALBINO RATS

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