Mechanisms and roles of the RNA-based gene silencing

RNA silencing is a remarkable type of gene regulation. This process has been found to occur in many different organisms such as plants (co-suppression), fungi (quelling), and animals (RNA interference; RNAi). Double-stranded RNA (dsRNA) is a potent trigger in RNA silencing mechanisms operating in a...

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Autores principales:	Jana,Snehasis, Chakraborty,Chiranjib, Nandi,Shyamsundar
Lenguaje:	English
Publicado:	Pontificia Universidad Católica de Valparaíso 2004
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582004000300015
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spelling	oai:scielo:S0717-345820040003000152005-12-12Mechanisms and roles of the RNA-based gene silencingJana,SnehasisChakraborty,ChiranjibNandi,Shyamsundar RNA silencing is a remarkable type of gene regulation. This process has been found to occur in many different organisms such as plants (co-suppression), fungi (quelling), and animals (RNA interference; RNAi). Double-stranded RNA (dsRNA) is a potent trigger in RNA silencing mechanisms operating in a wide range of organisms. This mechanism recognizes dsRNA and processes them into small 21-25nt RNAs (smRNAs). Small RNAs can guide post-transcriptional degradation of complementary messenger RNAs and in plants, transcriptional gene silencing is occurred by methylation of homologous DNA sequences. In plants, it serves as an antiviral defense, and many plant viruses encode suppressors of silencing such as helper component-proteinase of potyviruses (HC-Pro) and the p25 protein encoded by potato virus X (PVX). HC-Pro acts by preventing accumulation of smRNAs that provide specificity determinant for homologous RNA degradation, but p25 viral protein acts by targeting the mobile silencing signal. The encouraging view is that RNA silencing is part of a sophisticated network of interconnected pathways for cellular defense and development and that it may become a powerful tool to manipulate gene expression experimentally.info:eu-repo/semantics/openAccessPontificia Universidad Católica de ValparaísoElectronic Journal of Biotechnology v.7 n.3 20042004-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582004000300015en
institution	Scielo Chile
collection	Scielo Chile
language	English
description	RNA silencing is a remarkable type of gene regulation. This process has been found to occur in many different organisms such as plants (co-suppression), fungi (quelling), and animals (RNA interference; RNAi). Double-stranded RNA (dsRNA) is a potent trigger in RNA silencing mechanisms operating in a wide range of organisms. This mechanism recognizes dsRNA and processes them into small 21-25nt RNAs (smRNAs). Small RNAs can guide post-transcriptional degradation of complementary messenger RNAs and in plants, transcriptional gene silencing is occurred by methylation of homologous DNA sequences. In plants, it serves as an antiviral defense, and many plant viruses encode suppressors of silencing such as helper component-proteinase of potyviruses (HC-Pro) and the p25 protein encoded by potato virus X (PVX). HC-Pro acts by preventing accumulation of smRNAs that provide specificity determinant for homologous RNA degradation, but p25 viral protein acts by targeting the mobile silencing signal. The encouraging view is that RNA silencing is part of a sophisticated network of interconnected pathways for cellular defense and development and that it may become a powerful tool to manipulate gene expression experimentally.
author	Jana,Snehasis Chakraborty,Chiranjib Nandi,Shyamsundar
spellingShingle	Jana,Snehasis Chakraborty,Chiranjib Nandi,Shyamsundar Mechanisms and roles of the RNA-based gene silencing
author_facet	Jana,Snehasis Chakraborty,Chiranjib Nandi,Shyamsundar
author_sort	Jana,Snehasis
title	Mechanisms and roles of the RNA-based gene silencing
title_short	Mechanisms and roles of the RNA-based gene silencing
title_full	Mechanisms and roles of the RNA-based gene silencing
title_fullStr	Mechanisms and roles of the RNA-based gene silencing
title_full_unstemmed	Mechanisms and roles of the RNA-based gene silencing
title_sort	mechanisms and roles of the rna-based gene silencing
publisher	Pontificia Universidad Católica de Valparaíso
publishDate	2004
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582004000300015
work_keys_str_mv	AT janasnehasis mechanismsandrolesofthernabasedgenesilencing AT chakrabortychiranjib mechanismsandrolesofthernabasedgenesilencing AT nandishyamsundar mechanismsandrolesofthernabasedgenesilencing
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Mechanisms and roles of the RNA-based gene silencing

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