Silanol - A novel class of antimicrobial agent

Recently, a significant amount of attention has been directed toward development of novel classes of biocides because of the potential for microbial contamination and infection risks to military personnel and in the general population. We have recently discovered a new and unexpected class of powerf...

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Autores principales:	Kim,Yun-mi, Farrah,Samuel, Baney,Ronald H.
Lenguaje:	English
Publicado:	Pontificia Universidad Católica de Valparaíso 2006
Materias:	antimicrobial agents bacteria biocide silanols
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582006000200012
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spelling	oai:scielo:S0717-345820060002000122006-12-10Silanol - A novel class of antimicrobial agentKim,Yun-miFarrah,SamuelBaney,Ronald H. antimicrobial agents bacteria biocide silanols Recently, a significant amount of attention has been directed toward development of novel classes of biocides because of the potential for microbial contamination and infection risks to military personnel and in the general population. We have recently discovered a new and unexpected class of powerful biocides based upon compounds derived through simple chemistry from silicone intermediates, "silicon alcohols" called, silanols. One example is trialkylsilanols, R3SiOH. Antimicrobial tests were carried out against Gram-negative bacterium, Escherichia coli, and Gram-positive, Staphylococcus aureus, with silanols, t-butanol, and siloxanes. Trialkylsilanols were very effective biocides against Escherichia coli and Staphylococcus aureus. The number of viable bacteria reduced was more than eight orders of magnitude with silanol treatments. Triethylsilanol, in particular, exhibited a strong antimicrobial effect at a very low concentration within 10 min. These novel biocide silanols can be prepared from low cost intermediates derived from the commercial processesassociated with the silicone industry. Silanols are considered environmentally benign because of their transitory nature and ultimate conversion to CO2, SiO2, and H2O.info:eu-repo/semantics/openAccessPontificia Universidad Católica de ValparaísoElectronic Journal of Biotechnology v.9 n.2 20062006-04-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582006000200012en
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	antimicrobial agents bacteria biocide silanols
spellingShingle	antimicrobial agents bacteria biocide silanols Kim,Yun-mi Farrah,Samuel Baney,Ronald H. Silanol - A novel class of antimicrobial agent
description	Recently, a significant amount of attention has been directed toward development of novel classes of biocides because of the potential for microbial contamination and infection risks to military personnel and in the general population. We have recently discovered a new and unexpected class of powerful biocides based upon compounds derived through simple chemistry from silicone intermediates, "silicon alcohols" called, silanols. One example is trialkylsilanols, R3SiOH. Antimicrobial tests were carried out against Gram-negative bacterium, Escherichia coli, and Gram-positive, Staphylococcus aureus, with silanols, t-butanol, and siloxanes. Trialkylsilanols were very effective biocides against Escherichia coli and Staphylococcus aureus. The number of viable bacteria reduced was more than eight orders of magnitude with silanol treatments. Triethylsilanol, in particular, exhibited a strong antimicrobial effect at a very low concentration within 10 min. These novel biocide silanols can be prepared from low cost intermediates derived from the commercial processesassociated with the silicone industry. Silanols are considered environmentally benign because of their transitory nature and ultimate conversion to CO2, SiO2, and H2O.
author	Kim,Yun-mi Farrah,Samuel Baney,Ronald H.
author_facet	Kim,Yun-mi Farrah,Samuel Baney,Ronald H.
author_sort	Kim,Yun-mi
title	Silanol - A novel class of antimicrobial agent
title_short	Silanol - A novel class of antimicrobial agent
title_full	Silanol - A novel class of antimicrobial agent
title_fullStr	Silanol - A novel class of antimicrobial agent
title_full_unstemmed	Silanol - A novel class of antimicrobial agent
title_sort	silanol - a novel class of antimicrobial agent
publisher	Pontificia Universidad Católica de Valparaíso
publishDate	2006
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582006000200012
work_keys_str_mv	AT kimyunmi silanolanovelclassofantimicrobialagent AT farrahsamuel silanolanovelclassofantimicrobialagent AT baneyronaldh silanolanovelclassofantimicrobialagent
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Silanol - A novel class of antimicrobial agent

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