Multiple gene knock-down by a single lentiviral vector expressing an array of short hairpin RNAs

Multiple gene knock-down by a single lentiviral vector expressing an array of short hairpin RNAs

RNA interference (RNAi), mediated by short double-stranded RNAs, is a powerful mechanism for posttranscriptional gene silencing. Sustained expression of short hairpin RNA (shRNA) can be accomplished in mammalian cells by viral delivery systems. Using lentiviral constructs, stable gene silencing is e...

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Autores principales: Stove,Veronique, Smits,Kaatje, Naessens,Evelien, Plum,Jean, Verhasselt,Bruno
Lenguaje:English
Publicado: Pontificia Universidad Católica de Valparaíso 2006
Materias:
EGFP
lentiviral gene transfer
multiple knock-down
RNAi
Rho GTPases
shRNA
Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582006000500013
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