Recombinant human granulocyte-macrophage colony-stimulating factor: effect of glycosylation on pharmacokinetic parameters

The pharmacokinetic behaviour of the non-glycosylated, bacterially-derived recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) and the glycosylated mammalian product was studied after intra and extra vascular administration of a single dose in rodents. Each route of adminis...

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Autores principales:	Marini,Guillermo, Forno,Guillermina, Kratje,Ricardo, Etcheverrigaray,Marina
Lenguaje:	English
Publicado:	Pontificia Universidad Católica de Valparaíso 2007
Materias:	glycosylation pharmacokinetic parameters rhGM-CSF
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582007000200011
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spelling	oai:scielo:S0717-345820070002000112007-10-29Recombinant human granulocyte-macrophage colony-stimulating factor: effect of glycosylation on pharmacokinetic parametersMarini,GuillermoForno,GuillerminaKratje,RicardoEtcheverrigaray,Marina glycosylation pharmacokinetic parameters rhGM-CSF The pharmacokinetic behaviour of the non-glycosylated, bacterially-derived recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) and the glycosylated mammalian product was studied after intra and extra vascular administration of a single dose in rodents. Each route of administration gave a different rhGM-CSF concentration-time profile. After extra vascular administration of equivalent doses, a higher peak concentration and faster elimination were observed in the group treated with the E. coli-derived cytokine. The faster elimination resulted in a return to pre-treatment plasma levels after 12 hrs, versus 48 hrs following the administration of glycosylated rhGM-CSF. After intravascular administration, clearance of rhGM-CSF was significantly decreased by the presence of carbohydrates. Non-significant differences in the terminal phase of the biphasic kinetics were found, but the distribution phase was significantly longer for the glycosylated forminfo:eu-repo/semantics/openAccessPontificia Universidad Católica de ValparaísoElectronic Journal of Biotechnology v.10 n.2 20072007-04-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582007000200011en10.4067/S0717-34582007000200011
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	glycosylation pharmacokinetic parameters rhGM-CSF
spellingShingle	glycosylation pharmacokinetic parameters rhGM-CSF Marini,Guillermo Forno,Guillermina Kratje,Ricardo Etcheverrigaray,Marina Recombinant human granulocyte-macrophage colony-stimulating factor: effect of glycosylation on pharmacokinetic parameters
description	The pharmacokinetic behaviour of the non-glycosylated, bacterially-derived recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) and the glycosylated mammalian product was studied after intra and extra vascular administration of a single dose in rodents. Each route of administration gave a different rhGM-CSF concentration-time profile. After extra vascular administration of equivalent doses, a higher peak concentration and faster elimination were observed in the group treated with the E. coli-derived cytokine. The faster elimination resulted in a return to pre-treatment plasma levels after 12 hrs, versus 48 hrs following the administration of glycosylated rhGM-CSF. After intravascular administration, clearance of rhGM-CSF was significantly decreased by the presence of carbohydrates. Non-significant differences in the terminal phase of the biphasic kinetics were found, but the distribution phase was significantly longer for the glycosylated form
author	Marini,Guillermo Forno,Guillermina Kratje,Ricardo Etcheverrigaray,Marina
author_facet	Marini,Guillermo Forno,Guillermina Kratje,Ricardo Etcheverrigaray,Marina
author_sort	Marini,Guillermo
title	Recombinant human granulocyte-macrophage colony-stimulating factor: effect of glycosylation on pharmacokinetic parameters
title_short	Recombinant human granulocyte-macrophage colony-stimulating factor: effect of glycosylation on pharmacokinetic parameters
title_full	Recombinant human granulocyte-macrophage colony-stimulating factor: effect of glycosylation on pharmacokinetic parameters
title_fullStr	Recombinant human granulocyte-macrophage colony-stimulating factor: effect of glycosylation on pharmacokinetic parameters
title_full_unstemmed	Recombinant human granulocyte-macrophage colony-stimulating factor: effect of glycosylation on pharmacokinetic parameters
title_sort	recombinant human granulocyte-macrophage colony-stimulating factor: effect of glycosylation on pharmacokinetic parameters
publisher	Pontificia Universidad Católica de Valparaíso
publishDate	2007
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582007000200011
work_keys_str_mv	AT mariniguillermo recombinanthumangranulocytemacrophagecolonystimulatingfactoreffectofglycosylationonpharmacokineticparameters AT fornoguillermina recombinanthumangranulocytemacrophagecolonystimulatingfactoreffectofglycosylationonpharmacokineticparameters AT kratjericardo recombinanthumangranulocytemacrophagecolonystimulatingfactoreffectofglycosylationonpharmacokineticparameters AT etcheverrigaraymarina recombinanthumangranulocytemacrophagecolonystimulatingfactoreffectofglycosylationonpharmacokineticparameters
_version_	1718441767740637184

Recombinant human granulocyte-macrophage colony-stimulating factor: effect of glycosylation on pharmacokinetic parameters

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