Multiple model approach to modelling of Escherichia coli fed-batch cultivation extracellular production of bacterial phytase

The paper presents the implementation of multiple model approach to modelling of Escherichia coli BL21(DE3)pPhyt109 fed-batch cultivation processes for an extracellular production of bacterial phytase. Due to the complex metabolic pathways of microorganisms, the accurate modelling of bioprocesses is...

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Autores principales:	Roeva,Olympia, Pencheva,Tania, Tzonkov,Stoyan, Arndt,Michael, Hitzmann,Bernd, Kleist,Sofia, Miksch,Gerchard, Friehs,Karl, Flaschel,Erwin
Lenguaje:	English
Publicado:	Pontificia Universidad Católica de Valparaíso 2007
Materias:	genetic algorithms modelling multiple model approach
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582007000400012
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spelling	oai:scielo:S0717-345820070004000122009-01-19Multiple model approach to modelling of Escherichia coli fed-batch cultivation extracellular production of bacterial phytaseRoeva,OlympiaPencheva,TaniaTzonkov,StoyanArndt,MichaelHitzmann,BerndKleist,SofiaMiksch,GerchardFriehs,KarlFlaschel,Erwin genetic algorithms modelling multiple model approach The paper presents the implementation of multiple model approach to modelling of Escherichia coli BL21(DE3)pPhyt109 fed-batch cultivation processes for an extracellular production of bacterial phytase. Due to the complex metabolic pathways of microorganisms, the accurate modelling of bioprocesses is rather difficult. Multiple model approach is an alternative concept which helps in modelling and control of complex processes. The main idea is the development of a model based on simple submodels for the purposes of further high quality process control. The presented simulations of E. coli fed-batch cultivation show how the process could be divided into different functional states and how the model parameters could be obtained easily using genetic algorithms. The obtained results and model verification demonstrate the effectiveness of the applied concept of multiple model approach and of the proposed identification scheme.info:eu-repo/semantics/openAccessPontificia Universidad Católica de ValparaísoElectronic Journal of Biotechnology v.10 n.4 20072007-10-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582007000400012en10.4067/S0717-34582007000400012
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	genetic algorithms modelling multiple model approach
spellingShingle	genetic algorithms modelling multiple model approach Roeva,Olympia Pencheva,Tania Tzonkov,Stoyan Arndt,Michael Hitzmann,Bernd Kleist,Sofia Miksch,Gerchard Friehs,Karl Flaschel,Erwin Multiple model approach to modelling of Escherichia coli fed-batch cultivation extracellular production of bacterial phytase
description	The paper presents the implementation of multiple model approach to modelling of Escherichia coli BL21(DE3)pPhyt109 fed-batch cultivation processes for an extracellular production of bacterial phytase. Due to the complex metabolic pathways of microorganisms, the accurate modelling of bioprocesses is rather difficult. Multiple model approach is an alternative concept which helps in modelling and control of complex processes. The main idea is the development of a model based on simple submodels for the purposes of further high quality process control. The presented simulations of E. coli fed-batch cultivation show how the process could be divided into different functional states and how the model parameters could be obtained easily using genetic algorithms. The obtained results and model verification demonstrate the effectiveness of the applied concept of multiple model approach and of the proposed identification scheme.
author	Roeva,Olympia Pencheva,Tania Tzonkov,Stoyan Arndt,Michael Hitzmann,Bernd Kleist,Sofia Miksch,Gerchard Friehs,Karl Flaschel,Erwin
author_facet	Roeva,Olympia Pencheva,Tania Tzonkov,Stoyan Arndt,Michael Hitzmann,Bernd Kleist,Sofia Miksch,Gerchard Friehs,Karl Flaschel,Erwin
author_sort	Roeva,Olympia
title	Multiple model approach to modelling of Escherichia coli fed-batch cultivation extracellular production of bacterial phytase
title_short	Multiple model approach to modelling of Escherichia coli fed-batch cultivation extracellular production of bacterial phytase
title_full	Multiple model approach to modelling of Escherichia coli fed-batch cultivation extracellular production of bacterial phytase
title_fullStr	Multiple model approach to modelling of Escherichia coli fed-batch cultivation extracellular production of bacterial phytase
title_full_unstemmed	Multiple model approach to modelling of Escherichia coli fed-batch cultivation extracellular production of bacterial phytase
title_sort	multiple model approach to modelling of escherichia coli fed-batch cultivation extracellular production of bacterial phytase
publisher	Pontificia Universidad Católica de Valparaíso
publishDate	2007
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582007000400012
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Multiple model approach to modelling of Escherichia coli fed-batch cultivation extracellular production of bacterial phytase

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