Biocatalytic oxidative kinetic resolution of (±)-4-(chlorophenyl)phenylmethanol by Nocardia corallina B-276

Chiral diarylmethanols are versatile building blocks for the preparation of biologically active substances, but they are difficult to obtain in enantiopure form. We used Nocardia corallina B-276 for the oxidative kinetic resolution of (±)-4-(chlorophenyl)phenylmethanol, 1. Two experimental methods w...

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Autores principales:	Ramírez,Mario A., Pérez,Herminia I., Manjarrez,Norberto, Solís,Aida, Luna,Héctor, Cassani,Julia
Lenguaje:	English
Publicado:	Pontificia Universidad Católica de Valparaíso 2008
Materias:	4-chlorobenzophenone biocatalysis microbial oxidation resolution
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582008000400002
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spelling	oai:scielo:S0717-345820080004000022009-06-16Biocatalytic oxidative kinetic resolution of (±)-4-(chlorophenyl)phenylmethanol by Nocardia corallina B-276Ramírez,Mario A.Pérez,Herminia I.Manjarrez,NorbertoSolís,AidaLuna,HéctorCassani,Julia 4-chlorobenzophenone biocatalysis microbial oxidation resolution Chiral diarylmethanols are versatile building blocks for the preparation of biologically active substances, but they are difficult to obtain in enantiopure form. We used Nocardia corallina B-276 for the oxidative kinetic resolution of (±)-4-(chlorophenyl)phenylmethanol, 1. Two experimental methods were used: 1) Suspension of cells in a phosphate buffer solution and 2) Cells in the culture media, in a 3-L bioreactor. After 36 hrs using the first method, the ketone/alcohol ratio was 56/44 and the unoxidized alcohol had an enantiomeric ratio of 93/7, predominating the R-alcohol.info:eu-repo/semantics/openAccessPontificia Universidad Católica de ValparaísoElectronic Journal of Biotechnology v.11 n.4 20082008-10-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582008000400002en10.4067/S0717-34582008000400002
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	4-chlorobenzophenone biocatalysis microbial oxidation resolution
spellingShingle	4-chlorobenzophenone biocatalysis microbial oxidation resolution Ramírez,Mario A. Pérez,Herminia I. Manjarrez,Norberto Solís,Aida Luna,Héctor Cassani,Julia Biocatalytic oxidative kinetic resolution of (±)-4-(chlorophenyl)phenylmethanol by Nocardia corallina B-276
description	Chiral diarylmethanols are versatile building blocks for the preparation of biologically active substances, but they are difficult to obtain in enantiopure form. We used Nocardia corallina B-276 for the oxidative kinetic resolution of (±)-4-(chlorophenyl)phenylmethanol, 1. Two experimental methods were used: 1) Suspension of cells in a phosphate buffer solution and 2) Cells in the culture media, in a 3-L bioreactor. After 36 hrs using the first method, the ketone/alcohol ratio was 56/44 and the unoxidized alcohol had an enantiomeric ratio of 93/7, predominating the R-alcohol.
author	Ramírez,Mario A. Pérez,Herminia I. Manjarrez,Norberto Solís,Aida Luna,Héctor Cassani,Julia
author_facet	Ramírez,Mario A. Pérez,Herminia I. Manjarrez,Norberto Solís,Aida Luna,Héctor Cassani,Julia
author_sort	Ramírez,Mario A.
title	Biocatalytic oxidative kinetic resolution of (±)-4-(chlorophenyl)phenylmethanol by Nocardia corallina B-276
title_short	Biocatalytic oxidative kinetic resolution of (±)-4-(chlorophenyl)phenylmethanol by Nocardia corallina B-276
title_full	Biocatalytic oxidative kinetic resolution of (±)-4-(chlorophenyl)phenylmethanol by Nocardia corallina B-276
title_fullStr	Biocatalytic oxidative kinetic resolution of (±)-4-(chlorophenyl)phenylmethanol by Nocardia corallina B-276
title_full_unstemmed	Biocatalytic oxidative kinetic resolution of (±)-4-(chlorophenyl)phenylmethanol by Nocardia corallina B-276
title_sort	biocatalytic oxidative kinetic resolution of (±)-4-(chlorophenyl)phenylmethanol by nocardia corallina b-276
publisher	Pontificia Universidad Católica de Valparaíso
publishDate	2008
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582008000400002
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Biocatalytic oxidative kinetic resolution of (±)-4-(chlorophenyl)phenylmethanol by Nocardia corallina B-276

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