Novel antiviral activity of dialdehyde starch

A significant effort worldwide is being directed toward development of novel biocides against drug-resistant bacterial and viruses because of the significant potential human infection risks in the general population. We report here the discovery of a strong antiviral biocide, dialdheyde starch (DAS)...

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Autores principales:	Song,Le, Cruz,Caroline, Farrah,Samuel R, Baney,Ronald H
Lenguaje:	English
Publicado:	Pontificia Universidad Católica de Valparaíso 2009
Materias:	antiviral biocide dialdehyde starch virus
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582009000200013
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spelling	oai:scielo:S0717-345820090002000132009-10-20Novel antiviral activity of dialdehyde starchSong,LeCruz,CarolineFarrah,Samuel RBaney,Ronald H antiviral biocide dialdehyde starch virus A significant effort worldwide is being directed toward development of novel biocides against drug-resistant bacterial and viruses because of the significant potential human infection risks in the general population. We report here the discovery of a strong antiviral biocide, dialdheyde starch (DAS). Antiviral tests were carried out against three non-envelop viruses, including two bacterial viruses MS2 and PRD1, and one human virus Poliovirus. Dialdehyde starch aqueous suspensions were effective biocides against these three test viruses in a 1 hr exposure test. The antiviral activity was significantly enhanced in a four-hour exposure test, with maximum seven orders of magnitude reductions against MS2 and PRD1, and four-order reduction against Poliovirus. The antiviral activity of dialdehyde starch was found to be pH dependent, being more active in alkaline and acidic conditions than in neutral conditions.info:eu-repo/semantics/openAccessPontificia Universidad Católica de ValparaísoElectronic Journal of Biotechnology v.12 n.2 20092009-04-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582009000200013en10.4067/S0717-34582009000200013
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	antiviral biocide dialdehyde starch virus
spellingShingle	antiviral biocide dialdehyde starch virus Song,Le Cruz,Caroline Farrah,Samuel R Baney,Ronald H Novel antiviral activity of dialdehyde starch
description	A significant effort worldwide is being directed toward development of novel biocides against drug-resistant bacterial and viruses because of the significant potential human infection risks in the general population. We report here the discovery of a strong antiviral biocide, dialdheyde starch (DAS). Antiviral tests were carried out against three non-envelop viruses, including two bacterial viruses MS2 and PRD1, and one human virus Poliovirus. Dialdehyde starch aqueous suspensions were effective biocides against these three test viruses in a 1 hr exposure test. The antiviral activity was significantly enhanced in a four-hour exposure test, with maximum seven orders of magnitude reductions against MS2 and PRD1, and four-order reduction against Poliovirus. The antiviral activity of dialdehyde starch was found to be pH dependent, being more active in alkaline and acidic conditions than in neutral conditions.
author	Song,Le Cruz,Caroline Farrah,Samuel R Baney,Ronald H
author_facet	Song,Le Cruz,Caroline Farrah,Samuel R Baney,Ronald H
author_sort	Song,Le
title	Novel antiviral activity of dialdehyde starch
title_short	Novel antiviral activity of dialdehyde starch
title_full	Novel antiviral activity of dialdehyde starch
title_fullStr	Novel antiviral activity of dialdehyde starch
title_full_unstemmed	Novel antiviral activity of dialdehyde starch
title_sort	novel antiviral activity of dialdehyde starch
publisher	Pontificia Universidad Católica de Valparaíso
publishDate	2009
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582009000200013
work_keys_str_mv	AT songle novelantiviralactivityofdialdehydestarch AT cruzcaroline novelantiviralactivityofdialdehydestarch AT farrahsamuelr novelantiviralactivityofdialdehydestarch AT baneyronaldh novelantiviralactivityofdialdehydestarch
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Novel antiviral activity of dialdehyde starch

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