Vaccines for finfish aquaculture: What do we need to know to make them work?

Aquaculture still faces serious economic impacts due to the loss of animals to disease. A conservative estimate of 5% losses due to disease means that the finfish aquaculture industry loses over $1 billion annually on a global scale. One proven way to prevent costly disease outbreaks is to vaccinate...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autor principal:	Dixon,Brian
Lenguaje:	English
Publicado:	Pontificia Universidad Católica de Valparaíso 2012
Materias:	antibody antigen presentation cloning cytokine immunity major histocompatibility complex receptors
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582012000500014
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:scielo:S0717-34582012000500014
record_format	dspace
spelling	oai:scielo:S0717-345820120005000142012-11-29Vaccines for finfish aquaculture: What do we need to know to make them work?Dixon,Brian antibody antigen presentation cloning cytokine immunity major histocompatibility complex receptors Aquaculture still faces serious economic impacts due to the loss of animals to disease. A conservative estimate of 5% losses due to disease means that the finfish aquaculture industry loses over $1 billion annually on a global scale. One proven way to prevent costly disease outbreaks is to vaccinate fish against common or known pathogens. Current vaccination schemes still result in losses, however, and this may be due in part to vaccine design. Vaccines are currently designed using state of the art knowledge of immune responses, which is based primarily on mammalian studies. Just how applicable is this information to fish immunity and vaccine design, however? This review discusses what is currently known for teleost fish about two key processes that drive immune response: antigen presentation and cytokine regulation. In both cases many of the genes known to be involved have been identified; in the case of cytokines recent genome projects have added to the total rapidly in recent years. Most functional studies to date in these areas have focused on gene expression and mRNA levels, due to a lack of available antibodies that are required for studies at the protein level. These studies are confounded by the fact that in many cases the teleost equivalents of single copy mammalian genes are duplicated and are regulated in very different ways. This suggests that vaccines designed around mammalian immunological principles will not be as efficient as they could be. Future research goals for fish immunologists should be to develop the antibodies required for protein level functional studies in order to provide the true understanding of fish immunity that is required for the design of finfish aquaculture vaccines that are truly effective.info:eu-repo/semantics/openAccessPontificia Universidad Católica de ValparaísoElectronic Journal of Biotechnology v.15 n.5 20122012-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582012000500014en
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	antibody antigen presentation cloning cytokine immunity major histocompatibility complex receptors
spellingShingle	antibody antigen presentation cloning cytokine immunity major histocompatibility complex receptors Dixon,Brian Vaccines for finfish aquaculture: What do we need to know to make them work?
description	Aquaculture still faces serious economic impacts due to the loss of animals to disease. A conservative estimate of 5% losses due to disease means that the finfish aquaculture industry loses over $1 billion annually on a global scale. One proven way to prevent costly disease outbreaks is to vaccinate fish against common or known pathogens. Current vaccination schemes still result in losses, however, and this may be due in part to vaccine design. Vaccines are currently designed using state of the art knowledge of immune responses, which is based primarily on mammalian studies. Just how applicable is this information to fish immunity and vaccine design, however? This review discusses what is currently known for teleost fish about two key processes that drive immune response: antigen presentation and cytokine regulation. In both cases many of the genes known to be involved have been identified; in the case of cytokines recent genome projects have added to the total rapidly in recent years. Most functional studies to date in these areas have focused on gene expression and mRNA levels, due to a lack of available antibodies that are required for studies at the protein level. These studies are confounded by the fact that in many cases the teleost equivalents of single copy mammalian genes are duplicated and are regulated in very different ways. This suggests that vaccines designed around mammalian immunological principles will not be as efficient as they could be. Future research goals for fish immunologists should be to develop the antibodies required for protein level functional studies in order to provide the true understanding of fish immunity that is required for the design of finfish aquaculture vaccines that are truly effective.
author	Dixon,Brian
author_facet	Dixon,Brian
author_sort	Dixon,Brian
title	Vaccines for finfish aquaculture: What do we need to know to make them work?
title_short	Vaccines for finfish aquaculture: What do we need to know to make them work?
title_full	Vaccines for finfish aquaculture: What do we need to know to make them work?
title_fullStr	Vaccines for finfish aquaculture: What do we need to know to make them work?
title_full_unstemmed	Vaccines for finfish aquaculture: What do we need to know to make them work?
title_sort	vaccines for finfish aquaculture: what do we need to know to make them work?
publisher	Pontificia Universidad Católica de Valparaíso
publishDate	2012
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582012000500014
work_keys_str_mv	AT dixonbrian vaccinesforfinfishaquaculturewhatdoweneedtoknowtomakethemwork
_version_	1718441862817120256

Vaccines for finfish aquaculture: What do we need to know to make them work?

Ejemplares similares