Analysis of batch and repeated fedbatch productions of Candida utilis cell mass using mathematical modeling method

Background: Candida utilis is widely used in bioindustry, and its cell mass needs to be produced in a cost effective way. Process optimization based on the experimental results is the major way to reduce the production cost. However, this process is expensive, time consuming and labor intensive. Mat...

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Autores principales:	Lin,Yutian, Liu,Guoli, Lin,Huibin, Gao,Ling, Lin,Jianqiang
Lenguaje:	English
Publicado:	Pontificia Universidad Católica de Valparaíso 2013
Materias:	Candida utilis fermentation genetic algorithm mathematical model
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582013000400002
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spelling	oai:scielo:S0717-345820130004000022013-08-22Analysis of batch and repeated fedbatch productions of Candida utilis cell mass using mathematical modeling methodLin,YutianLiu,GuoliLin,HuibinGao,LingLin,Jianqiang Candida utilis fermentation genetic algorithm mathematical model Background: Candida utilis is widely used in bioindustry, and its cell mass needs to be produced in a cost effective way. Process optimization based on the experimental results is the major way to reduce the production cost. However, this process is expensive, time consuming and labor intensive. Mathematical modeling is a useful tool for process analysis and optimization. Furthermore, sufficient information can be obtained with fewer experiments by using the mathematical modeling, and some results can be predicted even without doing experiments. Results: In the present study, we performed the mathematical modeling and simulation for the cell mass production of Candida utilis based on limited batch and repeated fedbatch experiments. The model parameters were optimized using genetic algorithm (GA), and the processes were analyzed. Conclusions: Taken together, this newly developed method is efficient, labor saving and cost effective.info:eu-repo/semantics/openAccessPontificia Universidad Católica de ValparaísoElectronic Journal of Biotechnology v.16 n.4 20132013-07-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582013000400002en10.2225/vol16-issue4-fulltext-2
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Candida utilis fermentation genetic algorithm mathematical model
spellingShingle	Candida utilis fermentation genetic algorithm mathematical model Lin,Yutian Liu,Guoli Lin,Huibin Gao,Ling Lin,Jianqiang Analysis of batch and repeated fedbatch productions of Candida utilis cell mass using mathematical modeling method
description	Background: Candida utilis is widely used in bioindustry, and its cell mass needs to be produced in a cost effective way. Process optimization based on the experimental results is the major way to reduce the production cost. However, this process is expensive, time consuming and labor intensive. Mathematical modeling is a useful tool for process analysis and optimization. Furthermore, sufficient information can be obtained with fewer experiments by using the mathematical modeling, and some results can be predicted even without doing experiments. Results: In the present study, we performed the mathematical modeling and simulation for the cell mass production of Candida utilis based on limited batch and repeated fedbatch experiments. The model parameters were optimized using genetic algorithm (GA), and the processes were analyzed. Conclusions: Taken together, this newly developed method is efficient, labor saving and cost effective.
author	Lin,Yutian Liu,Guoli Lin,Huibin Gao,Ling Lin,Jianqiang
author_facet	Lin,Yutian Liu,Guoli Lin,Huibin Gao,Ling Lin,Jianqiang
author_sort	Lin,Yutian
title	Analysis of batch and repeated fedbatch productions of Candida utilis cell mass using mathematical modeling method
title_short	Analysis of batch and repeated fedbatch productions of Candida utilis cell mass using mathematical modeling method
title_full	Analysis of batch and repeated fedbatch productions of Candida utilis cell mass using mathematical modeling method
title_fullStr	Analysis of batch and repeated fedbatch productions of Candida utilis cell mass using mathematical modeling method
title_full_unstemmed	Analysis of batch and repeated fedbatch productions of Candida utilis cell mass using mathematical modeling method
title_sort	analysis of batch and repeated fedbatch productions of candida utilis cell mass using mathematical modeling method
publisher	Pontificia Universidad Católica de Valparaíso
publishDate	2013
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582013000400002
work_keys_str_mv	AT linyutian analysisofbatchandrepeatedfedbatchproductionsofcandidautiliscellmassusingmathematicalmodelingmethod AT liuguoli analysisofbatchandrepeatedfedbatchproductionsofcandidautiliscellmassusingmathematicalmodelingmethod AT linhuibin analysisofbatchandrepeatedfedbatchproductionsofcandidautiliscellmassusingmathematicalmodelingmethod AT gaoling analysisofbatchandrepeatedfedbatchproductionsofcandidautiliscellmassusingmathematicalmodelingmethod AT linjianqiang analysisofbatchandrepeatedfedbatchproductionsofcandidautiliscellmassusingmathematicalmodelingmethod
_version_	1718441875239600128

Analysis of batch and repeated fedbatch productions of Candida utilis cell mass using mathematical modeling method

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