Modeling of glutamic acid production by Lactobacillus plantarum MNZ

Background: L-glutamic acid, the principal excitatory neurotransmitter in the brain and an important intermediate in metabolism acts as a precursor of γ-amino butyric acid (GABA). In the present study, culture condition for enhanced glutamic acid production by Lactobacillus plantarum MNZ wa...

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Autores principales:	Zareian,Mohsen, Ebrahimpour,Afshin, Mohamed,Abdul Karim Sabo, Saari,Nazamid
Lenguaje:	English
Publicado:	Pontificia Universidad Católica de Valparaíso 2013
Materias:	γ-amino butyric acid functional foods lactic acid bacteria medium optimization response surface methodology
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582013000400012
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spelling	oai:scielo:S0717-345820130004000122013-08-22Modeling of glutamic acid production by Lactobacillus plantarum MNZZareian,MohsenEbrahimpour,AfshinMohamed,Abdul Karim SaboSaari,Nazamid γ-amino butyric acid functional foods lactic acid bacteria medium optimization response surface methodology Background: L-glutamic acid, the principal excitatory neurotransmitter in the brain and an important intermediate in metabolism acts as a precursor of γ-amino butyric acid (GABA). In the present study, culture condition for enhanced glutamic acid production by Lactobacillus plantarum MNZ was optimized and the influence of such conditions on GABA production was evaluated. Results: Results indicated that glutamic acid increased up to 3-fold (3.35) under the following condition: pH 4.5, temperature 37ºC, 12% (w/v) glucose and 0.7% (w/v) ammonium nitrate; whilst GABA production was enhanced up to 10-fold under the following condition: pH 4.5, temperature 37ºC, 6% (w/v) glucose and 0.7% (w/v) ammonium nitrate. Conclusions: This is the first report for dual biosynthesizing activities of a lactic acid bacterium for the production of glutamic acid and GABA. The results of this study can be further used for developing functional foods rich inglutamic acid and subsequently GABA as a bioactive compound.info:eu-repo/semantics/openAccessPontificia Universidad Católica de ValparaísoElectronic Journal of Biotechnology v.16 n.4 20132013-07-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582013000400012en10.2225/vol16-issue4-fulltext-10
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	γ-amino butyric acid functional foods lactic acid bacteria medium optimization response surface methodology
spellingShingle	γ-amino butyric acid functional foods lactic acid bacteria medium optimization response surface methodology Zareian,Mohsen Ebrahimpour,Afshin Mohamed,Abdul Karim Sabo Saari,Nazamid Modeling of glutamic acid production by Lactobacillus plantarum MNZ
description	Background: L-glutamic acid, the principal excitatory neurotransmitter in the brain and an important intermediate in metabolism acts as a precursor of γ-amino butyric acid (GABA). In the present study, culture condition for enhanced glutamic acid production by Lactobacillus plantarum MNZ was optimized and the influence of such conditions on GABA production was evaluated. Results: Results indicated that glutamic acid increased up to 3-fold (3.35) under the following condition: pH 4.5, temperature 37ºC, 12% (w/v) glucose and 0.7% (w/v) ammonium nitrate; whilst GABA production was enhanced up to 10-fold under the following condition: pH 4.5, temperature 37ºC, 6% (w/v) glucose and 0.7% (w/v) ammonium nitrate. Conclusions: This is the first report for dual biosynthesizing activities of a lactic acid bacterium for the production of glutamic acid and GABA. The results of this study can be further used for developing functional foods rich inglutamic acid and subsequently GABA as a bioactive compound.
author	Zareian,Mohsen Ebrahimpour,Afshin Mohamed,Abdul Karim Sabo Saari,Nazamid
author_facet	Zareian,Mohsen Ebrahimpour,Afshin Mohamed,Abdul Karim Sabo Saari,Nazamid
author_sort	Zareian,Mohsen
title	Modeling of glutamic acid production by Lactobacillus plantarum MNZ
title_short	Modeling of glutamic acid production by Lactobacillus plantarum MNZ
title_full	Modeling of glutamic acid production by Lactobacillus plantarum MNZ
title_fullStr	Modeling of glutamic acid production by Lactobacillus plantarum MNZ
title_full_unstemmed	Modeling of glutamic acid production by Lactobacillus plantarum MNZ
title_sort	modeling of glutamic acid production by lactobacillus plantarum mnz
publisher	Pontificia Universidad Católica de Valparaíso
publishDate	2013
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582013000400012
work_keys_str_mv	AT zareianmohsen modelingofglutamicacidproductionbylactobacillusplantarummnz AT ebrahimpourafshin modelingofglutamicacidproductionbylactobacillusplantarummnz AT mohamedabdulkarimsabo modelingofglutamicacidproductionbylactobacillusplantarummnz AT saarinazamid modelingofglutamicacidproductionbylactobacillusplantarummnz
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Modeling of glutamic acid production by Lactobacillus plantarum MNZ

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