Antibacterial activity of the Antarctic bacterium Janthinobacterium sp: SMN 33.6 against multi-resistant Gram-negative bacteria

Background The increment of resistant strains to commonly used antibiotics in clinical practices places in evidence the urgent need to search for new compounds with antibacterial activity. The adaptations that Antarctic microorganisms have developed, due to the extreme environment that they inhabit,...

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Autores principales:	Asencio,Geraldine, Lavin,Paris, Alegría,Karen, Domínguez,Mariana, Bello,Helia, González-Rocha,Gerardo, González-Aravena,Marcelo
Lenguaje:	English
Publicado:	Pontificia Universidad Católica de Valparaíso 2014
Materias:	Antarctica Antimicrobial Antibiotic resistance Bacterial pigment
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582014000100001
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spelling	oai:scielo:S0717-345820140001000012014-04-07Antibacterial activity of the Antarctic bacterium Janthinobacterium sp: SMN 33.6 against multi-resistant Gram-negative bacteriaAsencio,GeraldineLavin,ParisAlegría,KarenDomínguez,MarianaBello,HeliaGonzález-Rocha,GerardoGonzález-Aravena,Marcelo Antarctica Antimicrobial Antibiotic resistance Bacterial pigment Background The increment of resistant strains to commonly used antibiotics in clinical practices places in evidence the urgent need to search for new compounds with antibacterial activity. The adaptations that Antarctic microorganisms have developed, due to the extreme environment that they inhabit, promote them as a potential new source of active compounds for the control of microorganisms causing infections associated with health care. The aim of this study was to evaluate the antibacterial activity of an ethanol extract of the Antarctic bacterium Janthinobacterium sp., strain SMN 33.6, against nosocomial multi-resistant Gram-negative bacteria. Results Inhibitory activity against human Gram-negative bacterial pathogens, with concentrations that varied between 0.5 and 16 µg ml- 1, was demonstrated. Conclusions The ethanolic extract of Janthinobacterium sp. SMN 33.6 possesses antibacterial activity against a chromosomal AmpC beta-lactamase-producing strain of Serratia marcescens, an extended-spectrum beta-lactamase-producing Escherichia coli and also against carbapenemase-producing strains of Acinetobacter baumannii and Pseudomonas aeruginosa. This becomes a potential and interesting biotechnological tool for the control of bacteria with multi-resistance to commonly used antibiotics.info:eu-repo/semantics/openAccessPontificia Universidad Católica de ValparaísoElectronic Journal of Biotechnology v.17 n.1 20142014-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582014000100001en
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Antarctica Antimicrobial Antibiotic resistance Bacterial pigment
spellingShingle	Antarctica Antimicrobial Antibiotic resistance Bacterial pigment Asencio,Geraldine Lavin,Paris Alegría,Karen Domínguez,Mariana Bello,Helia González-Rocha,Gerardo González-Aravena,Marcelo Antibacterial activity of the Antarctic bacterium Janthinobacterium sp: SMN 33.6 against multi-resistant Gram-negative bacteria
description	Background The increment of resistant strains to commonly used antibiotics in clinical practices places in evidence the urgent need to search for new compounds with antibacterial activity. The adaptations that Antarctic microorganisms have developed, due to the extreme environment that they inhabit, promote them as a potential new source of active compounds for the control of microorganisms causing infections associated with health care. The aim of this study was to evaluate the antibacterial activity of an ethanol extract of the Antarctic bacterium Janthinobacterium sp., strain SMN 33.6, against nosocomial multi-resistant Gram-negative bacteria. Results Inhibitory activity against human Gram-negative bacterial pathogens, with concentrations that varied between 0.5 and 16 µg ml- 1, was demonstrated. Conclusions The ethanolic extract of Janthinobacterium sp. SMN 33.6 possesses antibacterial activity against a chromosomal AmpC beta-lactamase-producing strain of Serratia marcescens, an extended-spectrum beta-lactamase-producing Escherichia coli and also against carbapenemase-producing strains of Acinetobacter baumannii and Pseudomonas aeruginosa. This becomes a potential and interesting biotechnological tool for the control of bacteria with multi-resistance to commonly used antibiotics.
author	Asencio,Geraldine Lavin,Paris Alegría,Karen Domínguez,Mariana Bello,Helia González-Rocha,Gerardo González-Aravena,Marcelo
author_facet	Asencio,Geraldine Lavin,Paris Alegría,Karen Domínguez,Mariana Bello,Helia González-Rocha,Gerardo González-Aravena,Marcelo
author_sort	Asencio,Geraldine
title	Antibacterial activity of the Antarctic bacterium Janthinobacterium sp: SMN 33.6 against multi-resistant Gram-negative bacteria
title_short	Antibacterial activity of the Antarctic bacterium Janthinobacterium sp: SMN 33.6 against multi-resistant Gram-negative bacteria
title_full	Antibacterial activity of the Antarctic bacterium Janthinobacterium sp: SMN 33.6 against multi-resistant Gram-negative bacteria
title_fullStr	Antibacterial activity of the Antarctic bacterium Janthinobacterium sp: SMN 33.6 against multi-resistant Gram-negative bacteria
title_full_unstemmed	Antibacterial activity of the Antarctic bacterium Janthinobacterium sp: SMN 33.6 against multi-resistant Gram-negative bacteria
title_sort	antibacterial activity of the antarctic bacterium janthinobacterium sp: smn 33.6 against multi-resistant gram-negative bacteria
publisher	Pontificia Universidad Católica de Valparaíso
publishDate	2014
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582014000100001
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_version_	1718441885982261248

Antibacterial activity of the Antarctic bacterium Janthinobacterium sp: SMN 33.6 against multi-resistant Gram-negative bacteria

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