Diet high in α-linolenic acid up-regulate PPAR-α gene expression in the liver of goats
Background There is little information on the effects of diets containing high α-linolenic acid (C18:3n-3) on liver lipid composition and lipogenic gene expressions. In this study fourteen goats (Capra aegagrus hircus) were fed either a flaxseed oil (FSO) supplemented diet containing high &...
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Pontificia Universidad Católica de Valparaíso
2015
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oai:scielo:S0717-345820150003000112015-06-26Diet high in α-linolenic acid up-regulate PPAR-α gene expression in the liver of goatsEbrahimi,MahdiRajion,Mohamed AliMeng,Goh YongFarjam,Abdoreza SoleimaniOskoueian,EhsanJafari,Saeid Gene expression Goat Liver Omega-3 fatty acid PPAR Background There is little information on the effects of diets containing high α-linolenic acid (C18:3n-3) on liver lipid composition and lipogenic gene expressions. In this study fourteen goats (Capra aegagrus hircus) were fed either a flaxseed oil (FSO) supplemented diet containing high α-linolenic acid or a control diet without added flaxseed oil (CON) for 100-d to evaluate the effects on liver lipid composition and the gene expression of peroxisome proliferator-activated receptors (PPAR-α) and stearoyl-CoA-desaturase (SCD) in the liver. Results An increase in the levels of C18:3n-3 and C20:5n-3, C22:5n-3, C22:6n-3 was observed in the liver of FSO-treated goats. There was a significant (P < 0.05) up-regulation of PPAR-α gene expression and downregulation of SCD gene in the liver of goats fed the high α-linolenic acid diet. Conclusions In conclusion, genes associated with the control of fatty acid (FA) conversion (SCD and PPAR) were affected by the α-linolenic acid supplementation in the goat diet. It is suggested that PPAR-α is the key messenger responsible for the translation of nutritional stimuli into changes in hepatic gene expression.info:eu-repo/semantics/openAccessPontificia Universidad Católica de ValparaísoElectronic Journal of Biotechnology v.18 n.3 20152015-05-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582015000300011en10.1016/j.ejbt.2015.03.009 |
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Scielo Chile |
| collection |
Scielo Chile |
| language |
English |
| topic |
Gene expression Goat Liver Omega-3 fatty acid PPAR |
| spellingShingle |
Gene expression Goat Liver Omega-3 fatty acid PPAR Ebrahimi,Mahdi Rajion,Mohamed Ali Meng,Goh Yong Farjam,Abdoreza Soleimani Oskoueian,Ehsan Jafari,Saeid Diet high in α-linolenic acid up-regulate PPAR-α gene expression in the liver of goats |
| description |
Background There is little information on the effects of diets containing high α-linolenic acid (C18:3n-3) on liver lipid composition and lipogenic gene expressions. In this study fourteen goats (Capra aegagrus hircus) were fed either a flaxseed oil (FSO) supplemented diet containing high α-linolenic acid or a control diet without added flaxseed oil (CON) for 100-d to evaluate the effects on liver lipid composition and the gene expression of peroxisome proliferator-activated receptors (PPAR-α) and stearoyl-CoA-desaturase (SCD) in the liver. Results An increase in the levels of C18:3n-3 and C20:5n-3, C22:5n-3, C22:6n-3 was observed in the liver of FSO-treated goats. There was a significant (P < 0.05) up-regulation of PPAR-α gene expression and downregulation of SCD gene in the liver of goats fed the high α-linolenic acid diet. Conclusions In conclusion, genes associated with the control of fatty acid (FA) conversion (SCD and PPAR) were affected by the α-linolenic acid supplementation in the goat diet. It is suggested that PPAR-α is the key messenger responsible for the translation of nutritional stimuli into changes in hepatic gene expression. |
| author |
Ebrahimi,Mahdi Rajion,Mohamed Ali Meng,Goh Yong Farjam,Abdoreza Soleimani Oskoueian,Ehsan Jafari,Saeid |
| author_facet |
Ebrahimi,Mahdi Rajion,Mohamed Ali Meng,Goh Yong Farjam,Abdoreza Soleimani Oskoueian,Ehsan Jafari,Saeid |
| author_sort |
Ebrahimi,Mahdi |
| title |
Diet high in α-linolenic acid up-regulate PPAR-α gene expression in the liver of goats |
| title_short |
Diet high in α-linolenic acid up-regulate PPAR-α gene expression in the liver of goats |
| title_full |
Diet high in α-linolenic acid up-regulate PPAR-α gene expression in the liver of goats |
| title_fullStr |
Diet high in α-linolenic acid up-regulate PPAR-α gene expression in the liver of goats |
| title_full_unstemmed |
Diet high in α-linolenic acid up-regulate PPAR-α gene expression in the liver of goats |
| title_sort |
diet high in α-linolenic acid up-regulate ppar-α gene expression in the liver of goats |
| publisher |
Pontificia Universidad Católica de Valparaíso |
| publishDate |
2015 |
| url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582015000300011 |
| work_keys_str_mv |
AT ebrahimimahdi diethighin945linolenicacidupregulateppar945geneexpressionintheliverofgoats AT rajionmohamedali diethighin945linolenicacidupregulateppar945geneexpressionintheliverofgoats AT menggohyong diethighin945linolenicacidupregulateppar945geneexpressionintheliverofgoats AT farjamabdorezasoleimani diethighin945linolenicacidupregulateppar945geneexpressionintheliverofgoats AT oskoueianehsan diethighin945linolenicacidupregulateppar945geneexpressionintheliverofgoats AT jafarisaeid diethighin945linolenicacidupregulateppar945geneexpressionintheliverofgoats |
| _version_ |
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