Antiproliferative evaluation of tall-oil docosanol and tetracosanol over CHO-K1 and human melanoma cells

Background Polycosanols derived from plant species have traditionally been used in medicine as antiproliferative agents for treating various viruses (primarily the herpes simplex virus). However, few studies have studied their effects on hyperproliferative cell lines. In this work, the antiprolifera...

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Autores principales:	Vergara,Mauricio, Olivares,Araceli, Altamirano,Claudia
Lenguaje:	English
Publicado:	Pontificia Universidad Católica de Valparaíso 2015
Materias:	CHO-K1 cells Growth-arrested Human melanoma cells Polycosanols
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582015000400006
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spelling	oai:scielo:S0717-345820150004000062015-12-04Antiproliferative evaluation of tall-oil docosanol and tetracosanol over CHO-K1 and human melanoma cellsVergara,MauricioOlivares,AraceliAltamirano,Claudia CHO-K1 cells Growth-arrested Human melanoma cells Polycosanols Background Polycosanols derived from plant species have traditionally been used in medicine as antiproliferative agents for treating various viruses (primarily the herpes simplex virus). However, few studies have studied their effects on hyperproliferative cell lines. In this work, the antiproliferative capacity of polycosanols from tall-oil pitch, obtained from black liquor soaps in the kraft pulping process of cellulose (specifically from Pinus radiata, Pinus taede, and Eucalyptus globulus), was evaluated on CHO-K1 and CRL-1974 human melanoma cell lines. Results The proliferative capacities and cell viabilities were measured for 72 and 140 h, respectively. Treatment with docosanol produced differential effects on the CHO-K1 and human melanoma cells and significantly affected their proliferation rates, but not their cell viabilities. Tetracosanol produced a significant negative effect on the proliferation of human melanoma cells, and this effect was less than that caused by docosanol. However, it had no effect on the proliferation of CHO-K1 cells and did not induce any significant effect on the viability of the studied cell lines. Conclusion Docosanol and tetracosanol induced antiproliferative effects on the studied cell lines and exhibited significantly greater effects on the oncogenic cell lines. Prior to this study, the capacity of these polycosanols has never been investigated. Future studies will be necessary to determine their mechanisms of action on these cell systems.info:eu-repo/semantics/openAccessPontificia Universidad Católica de ValparaísoElectronic Journal of Biotechnology v.18 n.4 20152015-07-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582015000400006en10.1016/j.ejbt.2015.05.004
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	CHO-K1 cells Growth-arrested Human melanoma cells Polycosanols
spellingShingle	CHO-K1 cells Growth-arrested Human melanoma cells Polycosanols Vergara,Mauricio Olivares,Araceli Altamirano,Claudia Antiproliferative evaluation of tall-oil docosanol and tetracosanol over CHO-K1 and human melanoma cells
description	Background Polycosanols derived from plant species have traditionally been used in medicine as antiproliferative agents for treating various viruses (primarily the herpes simplex virus). However, few studies have studied their effects on hyperproliferative cell lines. In this work, the antiproliferative capacity of polycosanols from tall-oil pitch, obtained from black liquor soaps in the kraft pulping process of cellulose (specifically from Pinus radiata, Pinus taede, and Eucalyptus globulus), was evaluated on CHO-K1 and CRL-1974 human melanoma cell lines. Results The proliferative capacities and cell viabilities were measured for 72 and 140 h, respectively. Treatment with docosanol produced differential effects on the CHO-K1 and human melanoma cells and significantly affected their proliferation rates, but not their cell viabilities. Tetracosanol produced a significant negative effect on the proliferation of human melanoma cells, and this effect was less than that caused by docosanol. However, it had no effect on the proliferation of CHO-K1 cells and did not induce any significant effect on the viability of the studied cell lines. Conclusion Docosanol and tetracosanol induced antiproliferative effects on the studied cell lines and exhibited significantly greater effects on the oncogenic cell lines. Prior to this study, the capacity of these polycosanols has never been investigated. Future studies will be necessary to determine their mechanisms of action on these cell systems.
author	Vergara,Mauricio Olivares,Araceli Altamirano,Claudia
author_facet	Vergara,Mauricio Olivares,Araceli Altamirano,Claudia
author_sort	Vergara,Mauricio
title	Antiproliferative evaluation of tall-oil docosanol and tetracosanol over CHO-K1 and human melanoma cells
title_short	Antiproliferative evaluation of tall-oil docosanol and tetracosanol over CHO-K1 and human melanoma cells
title_full	Antiproliferative evaluation of tall-oil docosanol and tetracosanol over CHO-K1 and human melanoma cells
title_fullStr	Antiproliferative evaluation of tall-oil docosanol and tetracosanol over CHO-K1 and human melanoma cells
title_full_unstemmed	Antiproliferative evaluation of tall-oil docosanol and tetracosanol over CHO-K1 and human melanoma cells
title_sort	antiproliferative evaluation of tall-oil docosanol and tetracosanol over cho-k1 and human melanoma cells
publisher	Pontificia Universidad Católica de Valparaíso
publishDate	2015
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582015000400006
work_keys_str_mv	AT vergaramauricio antiproliferativeevaluationoftalloildocosanolandtetracosanoloverchok1andhumanmelanomacells AT olivaresaraceli antiproliferativeevaluationoftalloildocosanolandtetracosanoloverchok1andhumanmelanomacells AT altamiranoclaudia antiproliferativeevaluationoftalloildocosanolandtetracosanoloverchok1andhumanmelanomacells
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Antiproliferative evaluation of tall-oil docosanol and tetracosanol over CHO-K1 and human melanoma cells

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