Active anti-acetylcholinesterase component of secondary metabolites produced by the endophytic fungi of Huperzia serrata

Background An endophytic fungus lives within a healthy plant during certain stages of, or throughout, its life cycle. Endophytic fungi do not always cause plant disease, and they include fungi that yield different effects, including mutual benefit, and neutral and pathogenic effects. Endophytic fung...

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Autores principales:	Wang,Zhejian, Ma,Zhao, Wang,Lili, Tang,Chengchen, Hu,Zhibi, Chou,GuiXin, Li,Wankui
Lenguaje:	English
Publicado:	Pontificia Universidad Católica de Valparaíso 2015
Materias:	Anti-acetylcholinesterase activity Acetylcholinesterase inhibitor Biological characteristics Endophytic fungi
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582015000600003
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spelling	oai:scielo:S0717-345820150006000032016-01-21Active anti-acetylcholinesterase component of secondary metabolites produced by the endophytic fungi of Huperzia serrataWang,ZhejianMa,ZhaoWang,LiliTang,ChengchenHu,ZhibiChou,GuiXinLi,Wankui Anti-acetylcholinesterase activity Acetylcholinesterase inhibitor Biological characteristics Endophytic fungi Background An endophytic fungus lives within a healthy plant during certain stages of, or throughout, its life cycle. Endophytic fungi do not always cause plant disease, and they include fungi that yield different effects, including mutual benefit, and neutral and pathogenic effects. Endophytic fungi promote plant growth, improve the host plant's resistance to biotic and abiotic stresses, and can produce the same or similar biologically active substances as the host. Thus, endophytic fungal products have important implications in drug development. Result Among the numerous endophytic fungi, we identified two strains, L10Q37 and LQ2F02, that have anti-acetylcholinesterase activity, but the active compound was not huperzine A. The aim of this study was to investigate the anti-acetylcholinesterase activity of secondary metabolites isolated from the endophytic fungi of Huperzia serrata. Microbial cultivation and fermentation were used to obtain secondary metabolites. Active components were then extracted from the secondary metabolites, and their activities were tracked. Two compounds that were isolated from endophytic fungi of H. serrata were identified and had acetylcholine inhibitory activities. In conclusion, endophytic fungal strains were found in H. serrata that had the same anti-acetylcholinesterase activity. Conclusion We isolated 4 compounds from the endophytic fungus L10Q37, among them S1 and S3 are new compounds. 6 compounds were isolated from LQ2F02, all 6 compounds are new compounds. After tested anti acetylcholinesterase activity, S5 has the best activity. Other compounds' anti acetylcholinesterase activity was not better compared with huperzine A.info:eu-repo/semantics/openAccessPontificia Universidad Católica de ValparaísoElectronic Journal of Biotechnology v.18 n.6 20152015-11-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582015000600003en10.1016/j.ejbt.2015.08.005
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Anti-acetylcholinesterase activity Acetylcholinesterase inhibitor Biological characteristics Endophytic fungi
spellingShingle	Anti-acetylcholinesterase activity Acetylcholinesterase inhibitor Biological characteristics Endophytic fungi Wang,Zhejian Ma,Zhao Wang,Lili Tang,Chengchen Hu,Zhibi Chou,GuiXin Li,Wankui Active anti-acetylcholinesterase component of secondary metabolites produced by the endophytic fungi of Huperzia serrata
description	Background An endophytic fungus lives within a healthy plant during certain stages of, or throughout, its life cycle. Endophytic fungi do not always cause plant disease, and they include fungi that yield different effects, including mutual benefit, and neutral and pathogenic effects. Endophytic fungi promote plant growth, improve the host plant's resistance to biotic and abiotic stresses, and can produce the same or similar biologically active substances as the host. Thus, endophytic fungal products have important implications in drug development. Result Among the numerous endophytic fungi, we identified two strains, L10Q37 and LQ2F02, that have anti-acetylcholinesterase activity, but the active compound was not huperzine A. The aim of this study was to investigate the anti-acetylcholinesterase activity of secondary metabolites isolated from the endophytic fungi of Huperzia serrata. Microbial cultivation and fermentation were used to obtain secondary metabolites. Active components were then extracted from the secondary metabolites, and their activities were tracked. Two compounds that were isolated from endophytic fungi of H. serrata were identified and had acetylcholine inhibitory activities. In conclusion, endophytic fungal strains were found in H. serrata that had the same anti-acetylcholinesterase activity. Conclusion We isolated 4 compounds from the endophytic fungus L10Q37, among them S1 and S3 are new compounds. 6 compounds were isolated from LQ2F02, all 6 compounds are new compounds. After tested anti acetylcholinesterase activity, S5 has the best activity. Other compounds' anti acetylcholinesterase activity was not better compared with huperzine A.
author	Wang,Zhejian Ma,Zhao Wang,Lili Tang,Chengchen Hu,Zhibi Chou,GuiXin Li,Wankui
author_facet	Wang,Zhejian Ma,Zhao Wang,Lili Tang,Chengchen Hu,Zhibi Chou,GuiXin Li,Wankui
author_sort	Wang,Zhejian
title	Active anti-acetylcholinesterase component of secondary metabolites produced by the endophytic fungi of Huperzia serrata
title_short	Active anti-acetylcholinesterase component of secondary metabolites produced by the endophytic fungi of Huperzia serrata
title_full	Active anti-acetylcholinesterase component of secondary metabolites produced by the endophytic fungi of Huperzia serrata
title_fullStr	Active anti-acetylcholinesterase component of secondary metabolites produced by the endophytic fungi of Huperzia serrata
title_full_unstemmed	Active anti-acetylcholinesterase component of secondary metabolites produced by the endophytic fungi of Huperzia serrata
title_sort	active anti-acetylcholinesterase component of secondary metabolites produced by the endophytic fungi of huperzia serrata
publisher	Pontificia Universidad Católica de Valparaíso
publishDate	2015
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582015000600003
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Active anti-acetylcholinesterase component of secondary metabolites produced by the endophytic fungi of Huperzia serrata

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