Antimicrobial and molecular interaction studies on derivatives of curcumin against Streptococcus pneumoniae which caused pneumonia

Background: The antimicrobial properties and molecular interaction analysis of curcumin and its derivatives against three different strains of Streptococcus pneumoniae (Penicillin-susceptible, Penicillin-intermediate and Penicillin-resistant) are studied. Results: These properties were analyzed base...

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Autores principales:	Li,Liang-Mei, Li,Jun, Zhang,Xiu-Ying
Lenguaje:	English
Publicado:	Pontificia Universidad Católica de Valparaíso 2016
Materias:	Antimicrobial Curcumin MIC Molecular docking Penicillin-resistant
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582016000100002
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spelling	oai:scielo:S0717-345820160001000022016-05-11Antimicrobial and molecular interaction studies on derivatives of curcumin against Streptococcus pneumoniae which caused pneumoniaLi,Liang-MeiLi,JunZhang,Xiu-Ying Antimicrobial Curcumin MIC Molecular docking Penicillin-resistant Background: The antimicrobial properties and molecular interaction analysis of curcumin and its derivatives against three different strains of Streptococcus pneumoniae (Penicillin-susceptible, Penicillin-intermediate and Penicillin-resistant) are studied. Results: These properties were analyzed based on the measurement of the inhibition zone, minimum inhibitory concentration (MIC), and rate of kill revealed that curcumin monoglucoside, curcumin diglucoside and curcumin possessed strong antimicrobial properties even on the Penicillin-resistant strains. Additionally, the molecular docking simulation analyses against Penicillin Binding Protein of S. pneumoniae also confirm that these compounds docked at the active site of the enzyme. Further, the molecular dynamics simulation validates the conformational stability of the docked ligand-protein complexes in the dynamic environment. Conclusion: curcumin monoglucoside, curcumin diglucoside and curcumin can be prescribed for treatment against Penicillin-resistant S. pneumoniae.info:eu-repo/semantics/openAccessPontificia Universidad Católica de ValparaísoElectronic Journal of Biotechnology v.19 n.1 20162016-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582016000100002en10.1016/j.ejbt.2015.09.011
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Antimicrobial Curcumin MIC Molecular docking Penicillin-resistant
spellingShingle	Antimicrobial Curcumin MIC Molecular docking Penicillin-resistant Li,Liang-Mei Li,Jun Zhang,Xiu-Ying Antimicrobial and molecular interaction studies on derivatives of curcumin against Streptococcus pneumoniae which caused pneumonia
description	Background: The antimicrobial properties and molecular interaction analysis of curcumin and its derivatives against three different strains of Streptococcus pneumoniae (Penicillin-susceptible, Penicillin-intermediate and Penicillin-resistant) are studied. Results: These properties were analyzed based on the measurement of the inhibition zone, minimum inhibitory concentration (MIC), and rate of kill revealed that curcumin monoglucoside, curcumin diglucoside and curcumin possessed strong antimicrobial properties even on the Penicillin-resistant strains. Additionally, the molecular docking simulation analyses against Penicillin Binding Protein of S. pneumoniae also confirm that these compounds docked at the active site of the enzyme. Further, the molecular dynamics simulation validates the conformational stability of the docked ligand-protein complexes in the dynamic environment. Conclusion: curcumin monoglucoside, curcumin diglucoside and curcumin can be prescribed for treatment against Penicillin-resistant S. pneumoniae.
author	Li,Liang-Mei Li,Jun Zhang,Xiu-Ying
author_facet	Li,Liang-Mei Li,Jun Zhang,Xiu-Ying
author_sort	Li,Liang-Mei
title	Antimicrobial and molecular interaction studies on derivatives of curcumin against Streptococcus pneumoniae which caused pneumonia
title_short	Antimicrobial and molecular interaction studies on derivatives of curcumin against Streptococcus pneumoniae which caused pneumonia
title_full	Antimicrobial and molecular interaction studies on derivatives of curcumin against Streptococcus pneumoniae which caused pneumonia
title_fullStr	Antimicrobial and molecular interaction studies on derivatives of curcumin against Streptococcus pneumoniae which caused pneumonia
title_full_unstemmed	Antimicrobial and molecular interaction studies on derivatives of curcumin against Streptococcus pneumoniae which caused pneumonia
title_sort	antimicrobial and molecular interaction studies on derivatives of curcumin against streptococcus pneumoniae which caused pneumonia
publisher	Pontificia Universidad Católica de Valparaíso
publishDate	2016
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582016000100002
work_keys_str_mv	AT liliangmei antimicrobialandmolecularinteractionstudiesonderivativesofcurcuminagainststreptococcuspneumoniaewhichcausedpneumonia AT lijun antimicrobialandmolecularinteractionstudiesonderivativesofcurcuminagainststreptococcuspneumoniaewhichcausedpneumonia AT zhangxiuying antimicrobialandmolecularinteractionstudiesonderivativesofcurcuminagainststreptococcuspneumoniaewhichcausedpneumonia
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Antimicrobial and molecular interaction studies on derivatives of curcumin against Streptococcus pneumoniae which caused pneumonia

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