Over-expression of Mycobacterium neoaurum 3-ketosteroid-∆1-dehydrogenase in Corynebacterium crenatum for efficient bioconversion of 4-androstene-3,17-dione to androst-1,4-diene-3,17-dione

Over-expression of Mycobacterium neoaurum 3-ketosteroid-∆1-dehydrogenase in Corynebacterium crenatum for efficient bioconversion of 4-androstene-3,17-dione to androst-1,4-diene-3,17-dione

Background: 3-Ketosteroid-∆¹-dehydrogenase (KSDD), a flavoprotein enzyme, catalyzes the bioconversion of 4-androstene-3,17-dione (AD) to androst-1,4-diene-3,17-dione (ADD). To date, there has been no report about characterization of KSDD from Mycobacterium neoaurum strains, which were usua...

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Autores principales: Zhang,Xian, Wu,Dan, Yang,Taowei, Xu,Meijuan, Rao,Zhiming
Lenguaje:English
Publicado: Pontificia Universidad Católica de Valparaíso 2016
Materias:
Androst-1,4-diene-3,17-dione
Bioconversion
Codon optimization
Flavoprotein enzyme
Heterologous expression
Mycobacterium neoaurum
Overexpression
Recombinant Corynebacterium
Sterol catabolism
Whole-cell catalyst
Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582016000600013
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